Reticulin Patterns in the Diagnosis of Carcinomas and Sarcomas

Mackenzie, D. H.

doi:10.1038/bjc.1958.3

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…Gomori-stained sections of tumours produced during routine transplantation of MT1, or those produced by inoculation of cell lines and clones, revealed that reticulin fibres were not abundant but that in all cases they were arranged in an alveolar pattern surrounding groups of cells rather than in the pericellular pattern associated with mesenchymal cells [23]. However, this criterion alone is insufficient to define with any certainty the nature of the cells comprising anaplastic tumours.…”

Section: Reticulin Fibre Arrangementmentioning

confidence: 94%

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Barnett

Eccles

1984

Clin Exp Metast

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The biological and metastatic properties of cells from a murine mammary adenocarcinoma, MT1, were studied during serial transplantation in syngeneic hosts. Over 35 generations the tumour progressed from a well-differentiated, poorly metastatic neoplasm to an anaplastic highly metastatic state. At early passages the tumour yielded uniform cultures of cuboidal epithelial cells, at passage 17 both epitheloid and spindle type cells were present, and by passage 30 only spindle type cells were obtained. Epithelioid cell lines and clones when injected intravenously into syngeneic hosts produced lung colonies only, whereas spindle cell lines were capable of extensive extrapulmonary colonisation. Similar patterns of dissemination and growth were seen in spontaneous metastasis assays. In spite of the marked phenotypic differences in these 'subpopulations', their comparable ultrastructural features, oestrogen receptor levels, expression of MMTV antigens, DNA content and lectin binding profiles suggested a common cell lineage. It is proposed that these cell lines will be of use in the determination of tumour and host factors influencing tumour progression and the evolution of metastatic potential.

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Section: Reticulin Fibre Arrangementmentioning

confidence: 94%

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Barnett

Eccles

1984

Clin Exp Metast

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“…No differences were observed between sarcoma 37 and its irradiated " D " line, after I 0 serial half-lethal dose irradiations. Studies on the reticulin distribution in sarcoma 37 and B12 showed a sparse loose network in the centres of both tumours, reported by Mackenzie (1958) to be associated with anaplasia. The transition between this loose network and the denser, more regular concentric patterns in the capsule was gradual in control and abrupt in B12 tumours ( Fig.…”

Section: Resultsmentioning

confidence: 94%

Serial Irradiation of Mouse Tumours: Some Changes in Histology and Cytology

Pearson¹

1960

Br J Cancer

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THE method of seriaRy irradiating mouse tumours by transplantation into fresh hosts between each irradiation, enables histological changes to be observed divorced from the direct and indirect local effects of irradiation on the tumour bed. Snellman (1935) (Pearson, 1959a). One irradiated hne of sarcoma 37 received tumour sub-lethal doses of 3000 r at each stage (" B " hne) and one received half-lethal doses of 2000 r (" D " line). Tumour sub-lethal doses were administered at each stage to the homologous spindle-ceRed sarcoma BPI (" F " line) and mammary adenocarcinoma MV212 (" G " line). Tumour material for histological study was obtained from transplanted post-irradiation tumours from each irradiation stage and also from untreated sub-hne passages of the 12th stage of the sarcoma 37 cc B " line.The tumour material was treated with Susa fixative for 2 to 3 hours and embedded in paraffin wax by chloroform substitution from alcohol. Sections were cut at 6 # and stained in haematoxylin and eosin. RESULTSNo marked histological differences were apparent between tumou-rs of the spindle-ceRed sarcoma BPI (Fig. 2 and 3) and adenocarcinoma MV212 and their respective irradiated hnes cc F " and " G ". Small regions in c' G " line tumours

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“…The potential usefulness of the characterization of collagen pattern and distribution for cancer diagnosis has been suggested for many years [21] . Bolonyi studied the potential role of differential reticulin or type III collagen distribution for pathological classification of brain tumors [22] .…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Microscopy at 14 Tesla and Correlative Histopathology of Human Brain Tumor Tissue

et al. 2011

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Magnetic Resonance Microscopy (MRM) can provide high microstructural detail in excised human lesions. Previous MRM images on some experimental models and a few human samples suggest the large potential of the technique. The aim of this study was the characterization of specific morphological features of human brain tumor samples by MRM and correlative histopathology. We performed MRM imaging and correlative histopathology in 19 meningioma and 11 glioma human brain tumor samples obtained at surgery. To our knowledge, this is the first MRM direct structural characterization of human brain tumor samples. MRM of brain tumor tissue provided images with 35 to 40 µm spatial resolution. The use of MRM to study human brain tumor samples provides new microstructural information on brain tumors for better classification and characterization. The correlation between MRM and histopathology images allowed the determination of image parameters for critical microstructures of the tumor, like collagen patterns, necrotic foci, calcifications and/or psammoma bodies, vascular distribution and hemorrhage among others. Therefore, MRM may help in interpreting the Clinical Magnetic Resonance images in terms of cell biology processes and tissue patterns. Finally, and most importantly for clinical diagnosis purposes, it provides three-dimensional information in intact samples which may help in selecting a preferential orientation for the histopathology slicing which contains most of the informative elements of the biopsy. Overall, the findings reported here provide a new and unique microstructural view of intact human brain tumor tissue. At this point, our approach and results allow the identification of specific tissue types and pathological features in unprocessed tumor samples.

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Reticulin Patterns in the Diagnosis of Carcinomas and Sarcomas

Abstract: Images Figs. 5-8 Figs. 9-12 Figs. 1-4

Cited by 4 publications

References 5 publications

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Studies of mammary carcinoma metastasis in a mouse model system. I: Derivation and characterization of cells with different metastatic properties during tumour progression in vivo

Serial Irradiation of Mouse Tumours: Some Changes in Histology and Cytology

Magnetic Resonance Microscopy at 14 Tesla and Correlative Histopathology of Human Brain Tumor Tissue

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