Rotavirus Infection and Diarrhea Resulting in Transient Hyperphosphatasemia With No Evidence of Liver or Bone Disease

Transient hyperphosphatasaemia: An important condition to recognize

“…The pathogenesis of TH has yet to be defined precisely, 5 but it is thought to be multifactorial 13 . Viral infections do seem to be important triggering factors 14 . In the eight patients with gastroenteritis in this study, rotavirus was identified in two and varicella in one.…”

Transient hyperphosphatasemia after pediatric liver transplantation

“…So, it seems unlikely that transient hyperphosphatasemia is associated with drug use in both cases. In contrast, viral infections of gastrointestinal tract pathogens like Rotavirus, Echo 22, Enterovirus and Coxackie B5 are supposed especially to be triggering factors 9,10 . It is reported that there was an acute gastroenteritis attack in 60% of patients with transient hyperphosphatasia as like our cases 11 .…”

A harmless clinical condition presenting with dramatic elevation of alkaline phosphatase: bening transient hyperphosphatasemia of childhood

“…Hastalarda ALP yüksekliği dışında karaciğer ya da kemik hastalığı ile ilişkili klinik, laboratuvar ve radyolojik bulgu yoktur. Bu klinik duruma sıklıkla akut gastroenteritler, solunum yolu enfeksiyonları, bazı viral enfeksiyonlar (respiratuvar sinsityal virüs, enterovirus, HIV) ve astım eşlik etmektedir (6)(7)(8)(9) . Benzer tabloya bazen, karaciğer ve böbrek transplantasyonları sonrasında veya lenfoma gibi malign hastalıklarda da rastlanabilmektedir (10)(11)(12)(13)(14) .…”