Rotavirus gastroenteritis among children less than 5 years of age in private outpatient setting in urban India

Namjoshi, Gajanan S.; Mitra, Monjori; Lalwani, Sanjay; Anupam, Sachdeva; Balasubramanian, Sundaram; Babji, Sudhir; Ghosh, Apurba; Pandey, Sudhanshu; Kulkarni, Suhas; Goyal, Vimal Kant

doi:10.1016/j.vaccine.2014.03.070

Cited by 11 publications

(8 citation statements)

References 18 publications

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“…It is reported that rotavirus infections are at peak in the season of winter [12,21]. But in our study the rotavirus infections were evenly distributed among all the seasons of the year.…”

Section: Discussioncontrasting

confidence: 68%

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

et al. 2016

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Diarrheal diseases are responsible for a significant proportion of mortality and morbidity all around the globe. The contribution of viruses to gastroenteritis incidences in humans is well established. In the present study, we have studied the prevalence of rotavirus, norovirus and enterovirus in Himachal Pradesh, a north Indian state. A total of 287 (111 children and 176 adults) stool samples of gastroenteritis patients were screened for the viruses using RT-PCR method. 34.5 % samples were positive for the viral pathogens of gastroenteritis. Rotavirus was the predominant virus detected in the study with 49.5 and 14.8 % positivity in children and adults, respectively. Enterovirus was present in 5.6 % cases whereas norovirus had least prevalence (1.4 %). Co infection (rotavirus and enterovirus) was witnessed at the prevalence rate of 0.6 %. Among different age groups, the prevalence of studied viruses was highest in the children belonging to the age groups of \5 years. Rotavirus infections were found to be significantly associated with vomiting and trend of higher rates of fever and dehydration was seen in children along with diarrhea. Seasonal distribution shows circulation of diarrheagenic viruses throughout the year. This is the first report of prevalence of various diarrheagenic viruses circulating in this region. The outcome of the study from this cohort provides a baseline data which can be used to design the preventive strategies in the otherwise unexplored state of Himachal Pradesh.

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“…It is reported that rotavirus infections are at peak in the season of winter [12,21]. But in our study the rotavirus infections were evenly distributed among all the seasons of the year.…”

Section: Discussioncontrasting

confidence: 68%

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

et al. 2016

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“…The positive rate was higher than that of developed countries, such as England (14.3%) (Sethi et al, 2001); lower than that of some developing countries, such as Thailand (30%) (Chieochansin et al, 2016) and India (23%) (Namjoshi et al, 2014); and similar to the positive rate of rotavirus detection in Sudan (16%) (Magzoub et al, 2013). The danger to males was higher, and the ratio of infected males to females was 1.6:1.…”

Section: Discussionmentioning

confidence: 60%

Haze is an important medium for the spread of rotavirus

Mao

et al. 2016

Environmental Pollution

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“…Enteric viruses, especially rotavirus, have been considered as the leading pathogens of pediatric diarrhea worldwide [19, 20]. Other major enteric viruses causing childhood diarrhea included norovirus, human adenovirus(HAdV), human astrovirus, and sapovirus [17, 21–23].…”

Section: Discussionmentioning

confidence: 99%

Adenovirus associated with acute diarrhea: a case-control study

Qiu

Shen

et al. 2018

BMC Infect Dis

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BackgroundDiarrhea is a major source of morbidity and mortality among young children in low-income and middle-income countries. Human adenoviruses (HAdV), particular HAdV species F (40, 41) has been recognized as important causal pathogens, however limited data exist on molecular epidemiology of other HAdV associated with acute gastroenteritis.MethodsIn the present preliminary study, we performed a case-control study involving 273 children who presented diarrheal disease and 361 healthy children matched control in Children’s hospital of Hebei Province (China) to investigate the relationship between non-enteric HAdV and diarrhea. HAdV were detected and quantified using quantitative real-time PCR (qPCR) and serotyped by sequencing and phylogenetic analysis. Odds ratio (OR) was used to assess the risk factor of HAdV.ResultsHAdV were detected in 79 (28.94%) of 273 children with diarrhea including 7 different serotypes (HAdV 40, 41, 3, 2,1,5 and 57) with serotypes 40, 41 and 3 being the most dominant and in 26 (7.20%) of 361 healthy children containing 9 serotypes (HAdV 40, 41, 3, 2,1,5,57,6 and 31). A majority (91.14%) of HAdV positives occurred in diarrhea children and 65.38% in controls< 3 years of age. No significant difference in the viral load was found between case and control groups or between Ad41-positive patients and healthy controls. In addition to HAdV 40 and 41, HAdV 3 was also associated with diarrhea (OR = 17.301, adjusted OR = 9.205, p < 0.001).ConclusionsOur results demonstrate a high diversity of HAdV present among diarrhea and healthy children and implicate that non-enteric HAdV3 may lead to diarrhea.

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Rotavirus gastroenteritis among children less than 5 years of age in private outpatient setting in urban India

Cited by 11 publications

References 18 publications

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

Prevalence of rotavirus, norovirus and enterovirus in diarrheal diseases in Himachal Pradesh, India

Haze is an important medium for the spread of rotavirus

Adenovirus associated with acute diarrhea: a case-control study

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