Rotarod test and Catalepsy bar test: behavioral testing and neuromodulation of Aloe vera in MPTP induced Parkinson’s disease animal model

Abstract

Background: Aloe vera (Family Liliaceae) has been used for the treatment of diabetes, skin disorders and as anti-inflammatory agent. Objectives: behavioral testing of antiparkinsonian effect of Aloe vera in MPTP induced animal model.Methods: Rotarod test and Catalepsy bar test were used for behavioral assessment. Assessment of oxidative stress was done in the striatal region of the brain by reduced glutathione (GSH) measurement.Results: A. vera (200 and 400mg/kg, p.o.) was found to significantly increase the retention time in rota rod test and significantly decrease the latency period in catalepsy bar test as compared to MPTP groups. A. vera was found to have significant anti-oxidative effect in the striatal region of the brain by GSH measurement.Conclusions: Thus, it can be proposed that A. vera has a potential anti-parkinson effect in mice.

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“…In order to evaluate the effect of developed NPs upon motor coordination, previously reported Rotarod test procedure was applied [60] to observe the integrity of motor system. Briefly; Rotarod apparatus (30 cm long rod with 3 cm diameter) subdivided to three compartments with the help of disc (24 cm in diameter), rotates at a constant speed (10 rpm) and the trained animals (i.n.…”