Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

Sharma, Aruna; Mureșanu, Dafin F.; Castellani, Rudy J.; Nozari, Ala; Lafuente, José Vicente; Sahib, Seaab; Tian, Z. Ryan; Patnaik, Ranjana; Wiklund, Lars; Sharma, Hari Shanker

doi:10.1016/bs.pbr.2020.09.010

Cited by 21 publications

(2 citation statements)

References 398 publications

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“…Sterubin treatment showed anti-rotenone antioxidant potential by reducing ROT-induced endogenous antioxidant depletion along with oxynitrative stress in the mice. Mitochondrial malfunction and nitroxidative stress are two interconnected pathways that have been identified as key events in the degeneration of neurons in PD ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease

Alqurashi,

Al-Abbasi,

Afzal

et al. 2024

Braz J Med Biol Res

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This study was conducted to evaluate how sterubin affects rotenone-induced Parkinson's disease (PD) in rats. A total of 24 rats were distributed into 4 equal groups: normal saline control and rotenone control were administered saline or rotenone (ROT), respectively, orally; sterubin 10 received ROT + sterubin 10 mg/kg po ; and sterubin alone was administered to the test group (10 mg/kg). Rats of the normal saline and sterubin alone groups received sunflower oil injection ( sc ) daily, 1 h after receiving the treatments cited above, while rats of the other groups received rotenone injection (0.5 mg/kg, sc ). The treatment was continued over the course of 28 days daily. On the 29th day, catalepsy and akinesia were assessed. The rats were then euthanized, and the brain was extracted for estimation of endogenous antioxidants (MDA: malondialdehyde, GSH: reduced glutathione, CAT: catalase, SOD: superoxide dismutase), nitrative (nitrite) stress markers, neuroinflammatory cytokines, and neurotransmitter levels and their metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), dopamine (DA), norepinephrine (NE), serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA)). Akinesia and catatonia caused by ROT reduced the levels of endogenous antioxidants (GSH, CAT, and SOD), elevated the MDA level, and altered the levels of nitrites, neurotransmitters, and their metabolites. Sterubin restored the neurobehavioral deficits, oxidative stress, and metabolites of altered neurotransmitters caused by ROT. Results demonstrated the anti-Parkinson's activities of sterubin in ROT-treated rats.

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Section: Discussionmentioning

confidence: 99%

Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease

Alqurashi,

Al-Abbasi,

Afzal

et al. 2024

Braz J Med Biol Res

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“…MRI contrast agents may increase the diagnostic utility of routine clinical MRI, as well as offer insights into mTBI pathophysiology, in part through the detection of mTBI-induced changes in the BCSF barrier ( 16 , 17 ). Gadolinium [Gd(III)]–based contrast agents (GBCAs) are the standard choice for clinical MRI because of their strong paramagnetic properties, effective relaxation enhancement, excellent in vivo stability, and efficient clearance in patients without kidney diseases ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Preclinical characterization of macrophage-adhering gadolinium micropatches for MRI contrast after traumatic brain injury in pigs

Wang,

Gao,

Chandran Suja

et al. 2024

Sci. Transl. Med.

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The choroid plexus (ChP) of the brain plays a central role in orchestrating the recruitment of peripheral leukocytes into the central nervous system (CNS) through the blood-cerebrospinal fluid (BCSF) barrier in pathological conditions, thus offering a unique niche to diagnose CNS disorders. We explored whether magnetic resonance imaging of the ChP could be optimized for mild traumatic brain injury (mTBI). mTBI induces subtle, yet influential, changes in the brain and is currently severely underdiagnosed. We hypothesized that mTBI induces sufficient alterations in the ChP to cause infiltration of circulating leukocytes through the BCSF barrier and developed macrophage-adhering gadolinium [Gd(III)]–loaded anisotropic micropatches (GLAMs), specifically designed to image infiltrating immune cells. GLAMs are hydrogel-based discoidal microparticles that adhere to macrophages without phagocytosis. We present a fabrication process to prepare GLAMs at scale and demonstrate their loading with Gd(III) at high relaxivities, a key indicator of their effectiveness in enhancing image contrast and clarity in medical imaging. In vitro experiments with primary murine and porcine macrophages demonstrated that GLAMs adhere to macrophages also under shear stress and did not affect macrophage viability or functions. Studies in a porcine mTBI model confirmed that intravenously administered macrophage-adhering GLAMs provide a differential signal in the ChP and lateral ventricles at Gd(III) doses 500- to 1000-fold lower than those used in the current clinical standard Gadavist. Under the same mTBI conditions, Gadavist did not offer a differential signal at clinically used doses. Our results suggest that macrophage-adhering GLAMs could facilitate mTBI diagnosis.

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Amine Precursors in Depressive Disorders and the Blood-Brain Barrier

Sharma

2022

NeuroPsychopharmacotherapy

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Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology: Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin

Cited by 21 publications

References 398 publications

Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease

Protective effect of sterubin against neurochemical and behavioral impairments in rotenone-induced Parkinson's disease

Preclinical characterization of macrophage-adhering gadolinium micropatches for MRI contrast after traumatic brain injury in pigs

Amine Precursors in Depressive Disorders and the Blood-Brain Barrier

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