Rosmarinic and carnosic acid contents and correlated antioxidant and antidiabetic activities of 14 Salvia species from Anatolia

Adımcılar, Veselina; Kalaycıoğlu, Zeynep; Aydoğdu, Nihal; Dırmencı, Tuncay; Kahraman, Ahmet; Erim, F. Bedia

doi:10.1016/j.jpba.2019.07.011

Cited by 37 publications

(23 citation statements)

References 24 publications

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“…This acid was found to be the predominant compound of Salvia species. Strong correlations between the rosmarinic acid contents and bioactivites of Salvia samples were established [165]. Moreover, this acid demonstrated potent antiviral properties [164].…”

Section: Polyphenols As Extracted Biocompoundsmentioning

confidence: 92%

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

et al. 2020

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In Europe, pine forests are one of the most extended forests formations, making pine residues and by-products an important source of compounds with high industrial interest as well as for bioenergy production. Moreover, the valorization of lumber industry residues is desirable from a circular economy perspective. Different extraction methods and solvents have been used, resulting in extracts with different constituents and consequently with different bioactivities. Recently, emerging and green technologies as ultrasounds, microwaves, supercritical fluids, pressurized liquids, and electric fields have appeared as promising tools for bioactive compounds extraction in alignment with the Green Chemistry principles. Pine extracts have attracted the researchers’ attention because of the positive bioproperties, such as anti-inflammatory, antimicrobial, anti-neurodegenerative, antitumoral, cardioprotective, etc., and potential industrial applications as functional foods, food additives as preservatives, nutraceuticals, pharmaceuticals, and cosmetics. Phenolic compounds are responsible for many of these bioactivities. However, there is not much information in the literature about the individual phenolic compounds of extracts from the pine species. The present review is about the reutilization of residues and by-products from the pine species, using ecofriendly technologies to obtain added-value bioactive compounds for industrial applications.

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Section: Polyphenols As Extracted Biocompoundsmentioning

confidence: 92%

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

et al. 2020

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“…reported that the composition of lipids and fatty acids in Thai perilla seeds significantly varied among samples collected from different locations [ 18 , 19 ]. In addition to fatty acids, perilla seed is also a rich source of polyphenolic compounds such as RA, apigenin, and luteolin (which exhibits antioxidants), and possesses anti-inflammatory, antimicrobial, antialdoreductase, and alpha-glucosidase-inhibitory activities [ 20 , 21 , 22 , 23 , 24 ]. Commercially, perilla seed and its products are used in the health-food industry.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of a Rosmarinic Acid-Enriched Fraction Prepared from Nga-Mon (Perilla frutescens) Seed Meal on Osteoclastogenesis through the RANK Signaling Pathway

et al. 2021

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The aim of this study is to determine antioxidant and anti-inflammatory activities relating to the antiosteoporosis effects of various perilla seed meal (PSM) fractions. The remaining waste of perilla seed obtained from cold oil compression was extracted with 70% ethanol and sequentially fractionated according to solvent polarity with hexane, dichloromethane, ethyl acetate, and water. The results indicated that the seed-meal ethyl acetate fraction (SMEF) exhibited the highest antioxidant and anti-inflammatory activities, and rosmarinic acid (RA) content. The signaling pathways induced by the receptor activator of the nuclear factor kappa B (NF-κB) ligand (RANKL) that trigger reactive oxygen species (ROS) and several transcription factors, leading to the induction of osteoclastogenesis, were also investigated. The SMEF clearly showed attenuated RANKL-induced tartrate-resistant acid phosphatase (TRAP)-positive multinucleated osteoclasts and TRAP activity. A Western blot analysis showed that the SMEF significantly downregulated RANKL-induced NF-κB, AP-1 activation, and the nuclear factor of activated T-cell 1 (NFATc1) expression. SMEF also suppressed RANKL-induced osteoclast-specific marker gene-like MMP-9 using zymography. Furthermore, the SMEF showed inhibition of RANKL-induced ROS production in RAW 264.7 cells. The results suggest that the SMEF, which contained high quantities of RA, could be developed as a natural active pharmaceutical ingredient for osteoclastogenic protection and health promotion.

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“…Some phenolics compounds had greater inhibitory effect on BChE than AChE, this can be due to the number and position of OH/OCH 3 on the phenolic rings (aromatic compounds) (Szwajgier, 2013). (Adımcılar et al, 2019;Bahadori et al, 2017;Ben Khedher et al, 2018;Eidi & Eidi, 2009;Mocan et al, 2018;Nickavar, Abolhasani, & Izadpanah, 2010). In a previous study, the methanol extract of Salvia acetabulosa showed the highest inhibitory activity compared to the chloroform or hexane extracts (Loizzo et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…(2019) reported that the ME of Anatolian Salvia species including S. verbenaca inhibited effectively the α‐glucosidase enzyme with low concentrations. Various studies on different Salvia species were focused on the strong anti‐diabetic efficacies of different extracts compounds (Adımcılar et al., 2019; Bahadori et al., 2017; Ben Khedher et al., 2018; Eidi & Eidi, 2009; Mocan et al, 2018; Nickavar, Abolhasani, & Izadpanah, 2010). In a previous study, the methanol extract of Salvia acetabulosa showed the highest inhibitory activity compared to the chloroform or hexane extracts (Loizzo et al., 2008).…”

Section: Discussionmentioning

confidence: 99%

In vitro antioxidant, anticholinesterases, anti‐α‐amylase, and anti‐α‐glucosidase effects of AlgerianSalvia aegyptiacaandSalvia verbenaca

Mamache

Amira

Souici³

et al. 2020

J. Food Biochem.

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In this study, Salvia aegyptiaca and Salvia verbenaca aerial part decoction and methanol extracts (SAE DE, SAE ME, SVR DE, and SVR ME) were screened for their in vitro antioxidant, anti-Alzheimer, and antidiabetic enzymes inhibition activities. The antioxidant properties of Salvia extracts were determined using DPPH radical scavenging, ABTS radical scavenging, Alkaline DMSO superoxide radical scavenging, β-carotene bleaching, reducing power, and metal chelating activity assays. All extracts showed high antioxidant capacity and the antioxidant properties with the best performance were detected in the SAE ME and SVR ME. The extracts of S. aegyptiaca and S. verbenaca showed a low inhibitory activity of acetylcholinesterase (AChE), whereas, the methanol extract of S. aegyptiaca had the highest inhibitory activity on butyrylcholinesterase (BChE) (71.60 ± 4.33% for 100 µg/ml) compared to the other extracts. In vitro inhibitory effect on diabetic enzymes showed that the ME inhibited α-amylase enzyme with an IC 50 86 and 101 µg/ml for SAE and SVR, respectively. Similarly, both extracts inhibited α-glucosidase with (IC 50 97 and 150 µg/ ml, respectively). The decoction extracts exhibited lower activity on both enzymes.

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Rosmarinic and carnosic acid contents and correlated antioxidant and antidiabetic activities of 14 Salvia species from Anatolia

Cited by 37 publications

References 24 publications

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Green and Sustainable Valorization of Bioactive Phenolic Compounds from Pinus By-Products

Inhibitory Effect of a Rosmarinic Acid-Enriched Fraction Prepared from Nga-Mon (Perilla frutescens) Seed Meal on Osteoclastogenesis through the RANK Signaling Pathway

In vitro antioxidant, anticholinesterases, anti‐α‐amylase, and anti‐α‐glucosidase effects of AlgerianSalvia aegyptiacaandSalvia verbenaca

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