Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Amoah, Solomon Kweku Sagoe; Sandjo, Louis P.; Kratz, Jadel M.; Biavatti, Maique W.

doi:10.1055/s-0035-1568274

Cited by 180 publications

(139 citation statements)

References 253 publications

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“…Several studies have reported that RA has various biological and pharmacological activities, including anti-oxidant, anti-mutagenic, and anti-apoptotic activities13. Especially, several studies were reported that RA inhibited the induction of allergic-inflammatory reactions and indicated the antisepsis effect mediated by decreasing local and systemic levels of a wide spectrum of inflammatory mediators1415.…”

mentioning

confidence: 99%

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Jin

Chung

Cheon

et al. 2017

Sci Rep

137

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Ulcerative colitis (UC), a type of inflammatory bowel disease (IBD), is a chronic inflammatory disorder of the colon. Although UC is generally treated with anti-inflammatory drugs or immunosuppressants, most of these treatments often prove to be inadequate. Rosmarinic acid (RA) is a phenolic ester included in various medicinal herbs such as Salvia miltiorrhiz and Perilla frutescens. Although RA has many biological and pharmacological activities, the anti-inflammatory effect of RA in colonic tissue remains unclear. In this study, we investigated the anti-inflammatory effects and underlying molecular mechanism of RA in mice with dextran sulphate sodium (DSS)-induced colitis. In the DSS-induced colitis model, RA significantly reduced the severity of colitis, as assessed by disease activity index (DAI) scores, colonic damage, and colon length. In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1β, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis. Furthermore, RA effectively and pleiotropically inhibited nuclear factor-kappa B and signal transducer and activator of transcription 3 activation, and subsequently reduced the activity of pro-survival genes that depend on these transcription factors. These results demonstrate that RA has an ameliorative effect on colonic inflammation and thus a potential therapeutic role in colitis.

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mentioning

confidence: 99%

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Jin

Chung

Cheon

et al. 2017

Sci Rep

137

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“…1 ) is a natural hydroxylated phenolic compound present in many plants, including Rosmarinus officinalis , Artemisia capillaris , Callendula officinalis , Melissa officinalis , Salvia officinalis , perillae herba, and several other plant families [25] . Several biological activities are attributed to RA, such as antioxidant and anti-inflammatory properties and neuroprotective effects [26][27][28][29][30] . RA has been proven to be effective in experimental models of neurodegenerative diseases such as Alzheimer disease and amyotrophic lateral sclerosis [31,32] , and recently it was shown to have the interesting effect of reducing seizures in rats [27,[33][34][35] .…”

mentioning

confidence: 99%

Rosmarinic Acid Attenuates the Activation of Murine Microglial N9 Cells through the Downregulation of Inflammatory Cytokines and Cleaved Caspase-3

Coelho

Viau²,

Staub³

et al. 2017

Neuroimmunomodulation

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Objective: The present study evaluated the ability of rosmarinic acid (RA) to inhibit microglia activation induced by lipopolysaccharide (LPS) in the N9 murine microglial cell line, and investigated the putative mechanisms involved in this process. Methods: In all tests, N9 murine microglial cells were pretreated with RA (0.1, 1.0, and 10 μM) for 20 h and exposed to LPS (1 μM/mL) for 4 h. Cell viability was measured by Trypan blue exclusion assay. Flow cytometry was used to detect reactive oxygen species (ROS), quantify cleaved caspase-3, and analyze the mitochondrial electrochemical potential. iNOS, Arg-1, TNF-α, IL-1β, and IL-6 proteins were analyzed by Western blotting, and their antigens were detected using the chemiluminescence technique. The effect of RA on DNA was evaluated by the Comet assay. Results: RA attenuated the expression of the M1 marker iNOS and the levels of proinflammatory factors, including TNF-α, IL-1β, and IL-6; it increased the expression of the M2 marker Arg-1, and inhibited, at least in part, ROS generation and loss of mitochondrial outer membrane permeabilization through the inhibition of cleaved caspase-3 activation. RA also inhibited DNA damage, reassuring cell protection. Conclusions: The results suggested a protective effect of RA through downregulation of inflammatory cytokines and cleaved caspase-3.

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“…Rosmarinic acid (19) Z. clinopodioides [80] Review on pharmaceutical and clinical usage [113] Neuroprotective-review [114] General review on applications [115] Review on anticancer potential [116] O [94] n.f.…”

Section: O H O Och 2 Chmentioning

confidence: 99%

“…This compound showed antihypertensive, antioxidant and anti-inflammatory activities that can be connected with usage of Ziziphora against diseases of cardiovascular system [101][102][103][104][105][106][107][108][109][110][111][112]. Similarly, rosmarinic acid (19) possesses various activities, also connected with civilization diseases like cardiovascular system illnesses, chronic inflammations and cancer [113][114][115][116].…”

Section: Omementioning

confidence: 99%

Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora species represent the prototypical example of the Lamiaceae family. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes and phenolic substances belonging to the flavonoids. In Kazakh traditional medicine, Ziziphora species possess several medicinal uses. In particular, Z. bungeana Lam. and Z. clinopodioides Lam. are used for the treatment of illnesses related to the cardiovascular system or to combat different infections. Unfortunately, the majority of the information about the complex Ziziphora species is only available in Russian and Chinese language, therefore, we decided gather all available information on Kazakhstan Ziziphora, namely its content compounds, medicinal uses and published patents, to draw the attention of scientists to this very interesting plant with high medicinal potential.

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Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Cited by 180 publications

References 253 publications

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-κB and STAT3 activation

Rosmarinic Acid Attenuates the Activation of Murine Microglial N9 Cells through the Downregulation of Inflammatory Cytokines and Cleaved Caspase-3

Kazakh Ziziphora Species as Sources of Bioactive Substances

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