Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose

Azevedo, Marisa Frasson de; Lima, Cristóvão F.; Fernandes-Ferreira, Manuel; Almeida, M. J.; Wilson, Jonathan M.; Pereira‐Wilson, Cristina

doi:10.1002/mnfr.201000472

Cited by 43 publications

(31 citation statements)

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“…Pharmacokinetic studies have been conducted in rats. Azevedo et al showed that RA can modulate the transit of the intestinal Na+/glucose cotransporter-1 (SGLT-1) to the brush-border membrane, an effect that may contribute to the control of plasma glucose levels in diabetic rats [194]. Additionally, Debersac et al…”

Section: Pharmacokinetics In Animalsmentioning

confidence: 99%

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

et al. 2016

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The natural compound RA [(R)-(+)-rosmarinic acid, l " Fig. 1 is a common ester derived from caffeic acid and (R)-(+)-3-(3,4-dihydroxyphenyl)lactic acid that can accumulate in high amounts in many plant species. RA is abundant in several medicinal plants of the Lamiaceae family, such as rosemary (Rosmarinus officinalis L.), spearmint (Mentha spp.), and lemon balm (Melissa officinalis L.), and also in plants used in traditional Chinese medicine, such as Perilla frutescens (L.) Britton, Salvia miltiorrhiza Bunge, and Rabdosia rubescens (Hemsl.) H. Hara. Many studies have reported the role of RA in the biological activity of these plants as well as its pharmaceutical and biotechnological

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Section: Pharmacokinetics In Animalsmentioning

confidence: 99%

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

et al. 2016

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“…For example, extracts derived from peels and pulps of several apple varieties were able to inhibit α-glucosidase and α-amylase activity in vitro (Barbosa et al, 2010), and also, hydroxycinnamic acids like CGA were found to inhibit α-glucosidase activity in vitro (Matsui et al, 2004) as well as in vivo (Ishikawa et al, 2007). RA, a phenolic constituent of Greek sage herbal tea, significantly decreased rat intestinal SGLT1 levels in diabetic animals 14 days after daily intake with the drinking water (Azevedo et al, 2011). Recent human studies suggested that beverages such as apple juice as well as berries may improve short-term glycemic control (Hanhineva et al, 2010).…”

Section: Phenolic Acids and Diabetes Mellitus: Overview Of Potential mentioning

confidence: 99%

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

2015

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Diabetes mellitus (DM) has become a major public health threat across the globe. Current antidiabetic therapies are based on synthetic drugs that very often have side effects. It has been widely acknowledged that diet plays an important role in the management of diabetes. Phenolic acids are widely found in daily foods such as fruits, vegetables, cereals, legumes, and wine and they provide biological, medicinal, and health properties. Simple phenolic acids have been shown to increase glucose uptake and glycogen synthesis, improve glucose and lipid profiles of certain diseases (obesity, cardiovascular diseases, DM, and its complication). The current review is an attempt to list out the antidiabetic effects of simple phenolic acids from medicinal plants and botanical foods.

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“…As it is known that glucose apical can enter into the enterocytes via an active transport process mediated by SGLT1 transporters, and geared by the sodium gradient established by the Na + /K + ‐ATPase . Higher levels of Na + /K + ‐ATPase in STZ‐ or alloxan‐treated insulin‐dependent diabetic rodents contribute significantly to the increased glucose absorption in diabetes . The Na + /K + ‐ATPase in small intestine may play an important role in the reduction of plasma glucose after administration of green and black tea extracts.…”

Section: Discussionmentioning

confidence: 99%

“…Using the energy stored in the Na + electrochemical gradient, glucose is co‐transported with Na + through the brush border membrane of the enterocytes by Na + /glucose co‐transporter (SGLT1) . In addition, an increase in Na + /K + ‐ATPase expression in jejunal enterocytes is associated with diabetes in streptozotocin (STZ)‐ or alloxan‐treated insulin‐dependent diabetic rodents, resulting in increased monosaccharide absorption and aggravated undesirable postprandial hyperglycemia . Insulin, dopamine, rosmarinic acid, and the aqueous extract of banana infructescence stalks can delay the absorption of intestinal glucose by reducing Na + /K + ‐ATPase activity …”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effects of Green and Black Tea Extracts on Na⁺/K⁺‐ATPase Activity in Intestine of Type 1 and Type 2 Diabetic Mice

Liu

et al. 2019

Molecular Nutrition Food Res

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Scope Na+/K+‐ATPase is an important membrane‐bound enzyme and high levels of Na+/K+‐ATPase activity in intestine result in increased monosaccharide absorption and aggravated undesirable postprandial hyperglycemia in diabetic. The aim is to characterize the effects of green and black tea extracts on the intestinal Na+/K+‐ATPase. Methods and results The STZ‐induced type 1 diabetic mice model and high‐fat diet combined with low‐dose STZ‐induced type 2 diabetic mice model are used in this study and the data indicate that both green and black tea extracts show significant hypoglycemic effect. The Na+/K+‐ATPase activities in intestine associated with glucose absorption are increased in type 1 diabetic mice, while those are even normal in type 2 diabetic mice. Green and black tea extracts can attenuate type 1 diabetes‐induced intestinal Na+/K+‐ATPase disturbance to control postprandial hyperglycemia. Black tea is more effective than green tea in reducing of Na+/K+‐ATPase activity and protein expression. Theaflavins are the major functional components of black tea and theaflavine‐3,3′‐digallate presents the strongest inhibitory effect exhibiting anticompetition with ATP and mixed inhibition with Na+ and K+. Conclusion Tea, especially black tea, can be considered a potential therapeutic agent against type 1 diabetes‐induced intestinal Na+/K+‐ATPase disturbance to control postprandial hyperglycemia.

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Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose

Abstract: SFT and RA modulate the trafficking of SGLT1 to the BBM and may contribute to the control of plasma glucose.

Cited by 43 publications

References 50 publications

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

Comparison of the Effects of Green and Black Tea Extracts on Na⁺/K⁺‐ATPase Activity in Intestine of Type 1 and Type 2 Diabetic Mice

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Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose

Abstract: SFT and RA modulate the trafficking of SGLT1 to the BBM and may contribute to the control of plasma glucose.

Cited by 43 publications

References 50 publications

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Rosmarinic Acid – Pharmaceutical and Clinical Aspects

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

Comparison of the Effects of Green and Black Tea Extracts on Na+/K+‐ATPase Activity in Intestine of Type 1 and Type 2 Diabetic Mice

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Product

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About

Comparison of the Effects of Green and Black Tea Extracts on Na⁺/K⁺‐ATPase Activity in Intestine of Type 1 and Type 2 Diabetic Mice