Rosmarinic Acid as a Novel Agent in the Treatment of Allergies and Asthma*

Abstract

Rosmarinic acid, a caffeic acid ester and a component of several members of the Lamiaceae family including Rosmarinus officinalis, Perilla spp., and Salvia officinialis, has antioxidant and anti-inflammatory effects and is used for the treatment of asthma and reactive airway diseases, allergic disorders such as allergic rhinitis, otitis media, chemical sensitivity and multiple allergen reactivity. Rosmarinic acid can be used alone or in combination with other agents such as antioxidants, essential fatty acid supplements and other plant derived products. Rosmarinic acid can be administered orally and no adverse drug interactions have been reported. Nausea or mild stomach upset has been reported in sensitive patients in association with its oral intake and it is therefore recommended that Rosmarinic acid be ingested with food. Rosmarinic acid has shown free radical scavenging ability and suppression of allergic immunoglobulin and inflammatory responses of polymorphonuclear leukocytes, which may underlie its effectiveness in the treatment of allergic disorders, as demonstrated in clinical trials. Rosmarinic acid is a valuable agent for the treatment of allergic conditions, which is of importance considering the recent increase in the incidence of allergies, asthma and lung diseases associated with airborne pollutants.

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

“…RA is an ester of caffeic acid, present as the main phenolic component in several members of the Lamiaceae family including among others: Rosmarinus officinalis, Origanum spp., Perilla spp., and Salvia officinialis [36,37]. A few researchers reported RA as the main phenolic acid of various culinary herbs (oregano, thyme sage, and rosemary) in concentrations varying between 0.05 and 26 g/kg dry weight [38,39].…”

Rosmarinic acid: modes of action, medicinal values and health benefits

“…These reports include use of RA as an antioxidant, anti-microbial, anthelminthic, coccidiostat and anti-inflammatory agent, and as an endocrine and immune stimulant. In addition, improving the secretion of endogenous digestive enzymes, motility of the gut, motility of sperm, enhancing growth and production, as well as proven anti-allergy, anti-diabetic anti-angiogenic, anti-tumor and neuroprotective functions (Bulgakov et al , 2012; Petersen, 2013; Hossan et al , 2014; Stansbury, 2014; Kim et al , 2015; Nabavi et al , 2015). RA also affects feed conversion and utilization, growth and reproductive performance in addition to egg and meat quality of poultry (Bulgakov et al , 2012).…”

“…RA was shown to have both anti-oxidant and anti-inflammatory action by inhibiting lipoxygenase activity (Stansbury, 2014). In animals, Bacanli et al (2016) assessed the ability of RA to attenuate sepsis-induced oxidative stress by improving anti-oxidant indices and DNA repair capacity.…”

daptation of the in vitro Culture of Origanum majorana L. For Production of Phenolic Acids

“…These metabolites show antiviral, antiseptic, antioxidant, cholagogic, immunostimulating and spasmolytic activities [9]. Rosmarinic acid (RA) has various pharmacological activities such as antimutagenic [10], cardio protective [11], antimicrobial [12], antiviral [13], analgesic and anti-inflammatory activities [14]. In addition to its effect on diabetic neuropathy [15].…”