Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson’s Disease

Lv, Runxiao; Du, Lili; Zhou, Fenghua; Yuan, Xiangnan; Liu, Xueyong; Zhang, Lixin

doi:10.1021/acschemneuro.0c00375

Cited by 30 publications

(20 citation statements)

References 43 publications

(64 reference statements)

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“…PD mice were treated with miR-155-5p agomir. Upregulation of miR-155-5p invalidated the effect of RA, causing microglia activation and increased inflammation, leading to a worsening of motor skills [ 90 ].…”

Section: Mir-155mentioning

confidence: 99%

MiR-155: An Important Regulator of Neuroinflammation

Zingale

Gugliandolo

Mazzon

2021

IJMS

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MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-transcriptional level and that play an important role in many cellular processes, including modulation of inflammation. MiRNAs are present in high concentrations in the central nervous system (CNS) and are spatially and temporally expressed in a specific way. Therefore, an imbalance in the expression pattern of these small molecules can be involved in the development of neurological diseases. Generally, CNS responds to damage or disease through the activation of an inflammatory response, but many neurological disorders are characterized by uncontrolled neuroinflammation. Many studies support the involvement of miRNAs in the activation or inhibition of inflammatory signaling and in the promotion of uncontrolled neuroinflammation with pathological consequences. MiR-155 is a pro-inflammatory mediator of the CNS and plays an important regulatory role. The purpose of this review is to summarize how miR-155 is regulated and the pathological consequences of its deregulation during neuroinflammatory disorders, including multiple sclerosis, Alzheimer’s disease and other neuroinflammatory disorders. Modulation of miRNAs’ expression could be used as a therapeutic strategy in the treatment of pathological neuroinflammation.

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Section: Mir-155mentioning

confidence: 99%

MiR-155: An Important Regulator of Neuroinflammation

Zingale

Gugliandolo

Mazzon

2021

IJMS

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“…Treatment with recombinant CTRP12 decreases the expression of MCP-1, TNFα and IL-6 in LPS-treated macrophages 59 . Injection of miR-155-5p agomir increases TNF-α, IL-1β, and IL-6 amounts in the ventral midbrain of Parkinson's disease mice 60 . Additionally, LXRα overexpression induces M1 to M2 phenotypic transition in macrophages 61 .…”

Section: Discussionmentioning

confidence: 93%

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway

et al. 2021

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C1q tumor necrosis factor-related protein 12 (CTRP12), a conserved paralog of adiponectin, is closely associated with cardiovascular disease. However, little is known about its role in atherogenesis. The aim of this study was to examine the influence of CTRP12 on atherosclerosis and explore the underlying mechanisms. Our results showed that lentivirus-mediated CTRP12 overexpression inhibited lipid accumulation and inflammatory response in lipid-laden macrophages. Mechanistically, CTRP12 decreased miR-155-5p levels and then increased its target gene liver X receptor α (LXRα) expression, which increased ATP binding cassette transporter A1 (ABCA1)- and ABCG1-dependent cholesterol efflux and promoted macrophage polarization to the M2 phenotype. Injection of lentiviral vector expressing CTRP12 decreased atherosclerotic lesion area, elevated plasma high-density lipoprotein cholesterol levels, promoted reverse cholesterol transport (RCT), and alleviated inflammatory response in apolipoprotein E-deficient (apoE−/−) mice fed a Western diet. Similar to the findings of in vitro experiments, CTRP12 overexpression diminished miR-155-5p levels but increased LXRα, ABCA1, and ABCG1 expression in the aortas of apoE−/− mice. Taken together, these results suggest that CTRP12 protects against atherosclerosis by enhancing RCT efficiency and mitigating vascular inflammation via the miR-155-5p/LXRα pathway. Stimulating CTRP12 production could be a novel approach for reducing atherosclerosis.

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“…micro-RNAs play a pivotal role in the pathogenesis of neurodegenerative diseases. Lv et al ( 2020 ) demonstrated RA-mediated regulation of mi-miR-155-5p alleviating PD pathogenesis and concluded that suggesting that miR-155-5p could be used as a target for PD therapeutic management.…”

Section: Clinical Implications Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson’s Disease

Cited by 30 publications

References 43 publications

MiR-155: An Important Regulator of Neuroinflammation

MiR-155: An Important Regulator of Neuroinflammation

CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux and inhibiting inflammatory response via the miR-155-5p/LXRα pathway

Biomedical features and therapeutic potential of rosmarinic acid

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