Rosmarinic acid affects immunological and inflammatory mediator levels and restores lung pathological features in asthmatic rats

Shakeri, Farzaneh; Eftekhar, Naeima; Roshan, Nema Mohamadian; Rezaee, Ramin; Moghimi, Ali; Boskabady, Mohammad Hossein

doi:10.1016/j.aller.2018.04.004

Cited by 32 publications

(18 citation statements)

References 27 publications

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“…Previously, increased total WBC and neutrophil and eosinophil percentage in lung lavage of OVA-sensitized rats were shown [23,26]. Increased percentages of eosinophils were also demonstrated in sensitized animals and asthmatic patients that correlated with the severity of asthma and supported the results of the present study [27]. Activated eosinophils are critical in allergic reactions and induce respiratory hyperactivity in asthma [28].…”

Section: Discussionsupporting

confidence: 90%

“…Activation of monocytes also contributes to asthma pathogenesis by releasing reactive nitrogen species, total free radicals, and proliferation of 2-like lymphocytes in patients with asthma [33]. Both animal and human studies have shown increased PLA 2 and TP in asthma [27,34]. Consequently, higher levels of PLA 2 and TP in the BALF of asthmatic rats also confirm the induction of an animal model of asthma in the present study.…”

Section: Discussionsupporting

confidence: 81%

“…erefore, reduction of lymphocyte percentage could be due to increased total WBC of asthmatic animals [27]. If the absolute lymphocyte count was considered, it would be higher in the asthmatic rats compared to control group.…”

Section: Discussionmentioning

confidence: 99%

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The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats

Boskabady

Amin

Shakeri

2021

Evidence-Based Complementary and Alternative Medicine

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The effects of Curcuma longa (C. longa) on total and differential WBC, inflammatory and immunologic mediators, and oxidant and antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) of rats model of asthma were assessed. Animals were divided to 5 groups including control (C), asthma (sensitized to ovalbumin), and asthmatic groups treated with 0.75, 1.50, and 3.00 mg/ml C. longa (CL) and 1.25 μg/ml dexamethasone (D) (8 rats in each group). Total and differential WBC count, concentrations of phospholipase A2 (PLA2), total protein (TP), interferon-gamma (IFN-γ), interleukin-4 (IL-4), immunoglobulin E (IgE), NO2, NO3, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and thiol in BALF were assessed. Total and most differential WBC counts and BALF levels of PLA2, TP, IgE, IL-4, and oxidants in asthma group were higher but antioxidants and IFN-γ levels as well as IFN-γ/IL-4 ratio were lower than control group ( p < 0.001 for all cases). Total WBC and levels of PLA2, IgE, NO2, and NO3 were significantly reduced following treatment with C. longa, compared to asthma group ( p < 0.001 for all cases). In groups treated with dexamethasone and two higher concentrations of C. longa, neutrophil and eosinophil counts as well as TP, IL-4, and MDA levels were significantly decreased but IFN-γ, IFN-γ/IL-4 ratio, and antioxidants were increased (except IFN-γ/IL-4 ratio), compared to asthma group ( p < 0.05 to p < 0.001). Compared to dexamethasone, C. longa exerted more pronounced effects on lung inflammation, oxidative stress, and immune system in asthmatic rats.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 81%

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The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats

Boskabady

Amin

Shakeri

2021

Evidence-Based Complementary and Alternative Medicine

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“…In asthmatic rats, rosmarinic acid (0.125, 0.250, and 0.500 mg/ml) decreased the levels of IL-4, PLA2, IgE, and total protein, and increased the IFN-/IL-4 ratio in the BALF. Lung pathological changes induced by OVA were improved by rosmarinic acid treatment ( Shakeri et al, 2019 ). The findings of these works suggest a therapeutic effect for the extract of O. basilicum and its constituent, rosmarinic acid, on asthma ( Eftekhar et al, 2018a ; Eftekhar et al, 2018b ; Eftekhar et al, 2019a ).…”

Section: Resultsmentioning

confidence: 99%

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

2022

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Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.

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“…However, future studies in vivo settings are required to unveil the underlying protective mechanism of RA. In another study, Shakeri et al ( 2019 ) investigated the effects of RA on OVA-induced asthma and its influence on lung pathology of OVA-sensitized asthmatic rats. RA treatment significantly abridged IL-4, IgE, phospholipase A 2, and total protein levels but increased the IFN-γ/IL-4 ratio.…”

Section: Pharmacological Properties Of Ramentioning

confidence: 99%

Biomedical features and therapeutic potential of rosmarinic acid

et al. 2022

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For decades, the use of secondary metabolites of various herbs has been an attractive strategy in combating human diseases. Rosmarinic acid (RA) is a bioactive phenolic compound commonly found in plants of Lamiaceae and Boraginaceae families. RA is biosynthesized using amino acids tyrosine and phenylalanine via enzyme-catalyzed reactions. However, the chemical synthesis of RA involves an esterification reaction between caffeic acid and 3,4-dihydroxy phenyl lactic acid contributing two phenolic rings to the structure of RA. Several studies have ascertained multiple therapeutic benefits of RA in various diseases, including cancer, diabetes, inflammatory disorders, neurodegenerative disorders, and liver diseases. Many previous scientific papers indicate that RA can be used as an anti-plasmodic, anti-viral and anti-bacterial drug. In addition, due to its high anti-oxidant capacity, this natural polyphenol has recently gained attention for its possible application as a nutraceutical compound in the food industry. Here we provide state-of-the-art, flexible therapeutic potential and biomedical features of RA, its implications and multiple uses. Along with various valuable applications in safeguarding human health, this review further summarizes the therapeutic advantages of RA in various human diseases, including cancer, diabetes, neurodegenerative diseases. Furthermore, the challenges associated with the clinical applicability of RA have also been discussed.

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Rosmarinic acid affects immunological and inflammatory mediator levels and restores lung pathological features in asthmatic rats

Abstract: The results indicated a preventive effect for RA on immunological and inflammatory mediators as well as lung pathological changes in asthmatic rats which were comparable or even more potent than that of dexamethasone.

Cited by 32 publications

References 27 publications

The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats

The Effect of Curcuma longa on Inflammatory Mediators and Immunological, Oxidant, and Antioxidant Biomarkers in Asthmatic Rats

The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

Biomedical features and therapeutic potential of rosmarinic acid

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