Rosaï-Dorfman disease with tumoral skin lesions

Diallo, Moussa Salifou; Touré, M.; Diatta, B.A.; Diop, Assane; Ndiaye, M.; Seck, B.; Deh, Aminata; K, Diop; Niang, S.

doi:10.7241/ourd.2017s.10

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…Should management be warranted, such as in cases of lesions causing vital organ compression or in cases with serious disfigurement. In these situations surgery, radiation, systemic and intralesional corticosteroids, chemotherapy, antiviral therapy and immunomodulatory therapy have all been tried, with variable success [6,10]. The nodular lesions in our patient were partially but progressively responsive to serial intralesional triamcinolone acetonide injections.…”

Section: Discussionmentioning

confidence: 84%

“…Since CRD is extremely rare and the lesions are clinically variable, the disease may mimic different entities, including other histiocytosis, lymphoma, sarcoidosis and infectious processes [6,7]. The diagnosis of CRD is confirmed with histopathological examination and immunohistochemical studies.…”

Section: Discussionmentioning

confidence: 95%

“…While the disease has a capricious topographic distribution, facial skin is most commonly affected [4]. Of reported cases, the average age is around 45 years of age, women appear more affected than men (2:1) and the most cases have been seen among Caucasians and Asians [6].…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Rosai-Dorfman disease: A case report

Maghfour¹,

Mokni²,

Kahla³

et al. 2021

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Pure cutaneous Rosai-Dorfman is distinguished from classic Rosai-Dorfman disease by isolated skin involvement without lymphadenopathy or systemic symptoms. Herein, we report a case of a 30 year-old-man with 16 months history of a slowly enlarging, asymptomatic, purple plaque on her left cheek following cutaneous leishmaniasis successfully treated. The histopathological examination showed dense infiltration of inflammatory cells involving the entire dermis, consisting of large macrophages with emperipolesis, S100 and CD68 positive, lymphocytes and plasma cells. The patient was treated with intralesional triamcinolone with a significant improvement. The present article aimed to emphasise the clinical, histological differential diagnosis and to share the tumoral presentation of cutaneous Rosai-Dorfman disease.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 95%

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Cutaneous Rosai-Dorfman disease: A case report

Maghfour¹,

Mokni²,

Kahla³

et al. 2021

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“…The most common site of extranodal involvement is skin, with 10% of the all patients having skin lesions [1]. However, in approximately 3% of the cases, the disease is limited exclusively to the skin [1][2][3][4]. We report 2 cases with RDD, the first patient presented with cutaneous and lymph node involvement, while the other cutaneous only.…”

Section: Introductionmentioning

confidence: 90%

Rosai-Dorfman disease with primary cutaneous manifestations: report of two cases

Kaddioui¹,

Fetoiki²,

Hali³

2020

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Rosai-Dorfman disease (RDD),also named as sinus histiocytosis with massive lymphadenopathy, is a rare histiocytosis characterized by massive bilateral painless cervical lymphadenopathy and emperipolesis in tissue sections. We report the observation of 2 patients with a RDD, the first patient presented with cutaneous and lymph node involvement, while the other cutaneous only. The first patient was treated with methotrexate at a dose of 25 mg/week and oral corticosteroid 1 mg/kg/day completed by excision of the cutaneous lesions with a good evolution. Topical corticosteroids was used for the second patient with partial regression. Purely cutaneous Rosai-Dorfman disease is very rare and diagnosis is difficult without any lymphadenopathy or any distinguishing features of the skin lesion. However, a high index of suspicion by clinicians and pathologists with histopathological examination of the lesion may enable a correct diagnosis be made.

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“…Cutaneous form, which is limited to the skin, is extremely rare. The etiology of CRDD remains unknown with viral and immune causes hypothesized [1]. The clinical features of cutaneous Rosai-Dorfman disease are heterogeneous and can be just a single or, more commonly, multiple, papules, nodules or indurated plaques, of different sizes with no anatomical predilection localization [2].…”

Section: What Is Your Diagnosis?mentioning

confidence: 99%