Rosacea: a clinical review

Mikkelsen, Carsten Sauer; Holmgren, Helene Ringe; Kjellman, Petra; Heidenheim, Michael; Kappinnen, Ari; Bjerring, Peter; Huldt-Nystrøm, Theis

doi:10.4081/dr.2016.6387

Cited by 30 publications

(21 citation statements)

References 28 publications

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“…Rosacea is a chronic inflammatory skin disease that mostly affects middle-aged blonde women with light skin and blue eye, although it can be seen in any person [5,9]. Rosacea has multi-factorial pathology including vasoactive and neurocutaneous components as well as innate and acquired immunity.…”

Section: Discussionmentioning

confidence: 99%

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A case-control study on rosacea and vitamin D levels

Gürel¹,

Karadöl²,

Çölgeçen³

2018

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Rosacea is a chronic inflammatory dermatosis characterized by several features such as temporary erythema (flushing), permanent erythema, papules, pustules and telangiectasia in the face. In this study, our aim is to investigate the role of serum vitamin D levels in the pathogenesis of rosacea. Methods: 50 patients with rosacea and 50 age and gender matched healthy controls were included in this study. In patients with rosacea and control group, serum parathyroid hormone (PTH), vitamin D levels and serum calcium levels were measured and the results were compared statistically. Results: Serum vitamin D levels in patients with rosacea were significantly higher than the control group (respectively 10,55 ng/ml and 8,50 ng/ml). The median of serum calcium level was found to be 8,20 mg/dl in the group of patients with rosacea and 8,55 mg/dl in the control group. Serum calcium levels of the control group were significantly higher than the group of patients with rosacea. There was no statistically significant difference in terms of serum parathormone levels between the group of patients with rosacea and control group. The increase in serum vitamin D levels may lead development of rosacea. Conclusion: As a result, the increase in serum vitamin D levels is associated with rosacea. Öz Amaç: Rozasea yüz bölgesinde geçici eritem (flushing), kalıcı eritem, papül, püstül ve telenjiektazi gibi çeşitli özelliklerle karakterize olan kronik inflamatuvar bir dermatozdur Bu çalışmada amacımız rozasea patogenezine etki edebilecek serum vitamin D düzeylerinin rolünü araştırmaktır. Yöntemler: Dermatoloji polikliniğine başvuran 50 rozasea hastası ile yaş ve cinsiyet açısından eşleştirilmiş 50 sağlıklı kontrol grubu alındı. Rozasealı hastalarda ve kontrol grubunda serum paratiroid hormonu (PTH), D vitamin seviyeleri, serum kalsiyum düzeyleri ölçüldü ve istatistiksel olarak karşılaştırıldı. Bulgular: Rozasealı hasta grubunun serum 25-hidroksivitamin D düzeyi medianı 10,55 (6,30-38,60) ng/ml, kontrol grubunun ise 8,50 (4,50-25,60) ng/ml olarak saptandı. Rozasea'lı hasta grubunun serum vitamin D düzeyi kontrol grubundan anlamlı olarak yüksek bulundu (p=0,013). Rozasealı hasta grubunun serum kalsiyum düzeyi medianı 8,20 (7,20-9,20) mg/dl, kontrol grubunun ise 8,55(7,60-11,40) mg/dl olarak saptandı. Kontrol grubunun serum kalsiyum düzeyi rozasealı hasta grubundan anlamlı olarak yüksek bulundu (p=0,000). Rozasealı hasta grubu ve kontrol grubu arasında serum parathormon düzeyleri açısından istatistiksel olarak anlamlı farklılık saptanmadı (p=0,194). Sonuç: Serum vitamin D düzeylerinin yükselmesi rozasea gelişimi ile ilişkili olabilir. Anahtar kelimeler: Rozasea, Vitamin D, Katelisidin, Parathormon J...

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Section: Discussionmentioning

confidence: 99%

“…The expression of various genes that play a role in the innate and acquired immune systems has been shown to increase in patients with rosacea. Microorganisms such as Demodex folliculorum, Staphylococcus epidermidis, ultraviolet (UV) rays, and transient receptor potential family are among the blamed factors for the etiology [1,2,5].…”

Section: Introductionmentioning

confidence: 99%

A case-control study on rosacea and vitamin D levels

Gürel¹,

Karadöl²,

Çölgeçen³

2018

Journal of Surgery and Medicine

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“…[35][36][37][38][39][40][41][42][43] The large body of evidence supporting an inflammatory pathogenesis of rosacea that is not triggered by a bacterial etiology has led globally to rosacea management recommendations supporting that avoidance of an antibiotic effect whenever possible is favorable in order to reduce the emergence of antibiotic-resistant bacteria. [44][45][46][47] In their rosacea medical management guidelines, the American Acne & Rosacea Society stated the following: "The lack of data supporting a bacterial component definitively related to the pathogenesis of rosacea suggests overall that medical therapies which are anti-inflammatory in nature are best considered for initial treatment of rosacea, especially the inflammatory (papulopustular) subtype, with oral antibiotic agents used in cases that are poorly responsive to a reasonable trial of topical therapy and/or oral anti-inflammatory therapy". 44 To achieve this, available topical agents with demonstrated anti-inflammatory effects, efficacy, and safety in rosacea would include azelaic acid and ivermectin.…”

Section: -29 (3) Management Of Rosacea Does Not Require An Antibiotmentioning

confidence: 99%

“…44 To achieve this, available topical agents with demonstrated anti-inflammatory effects, efficacy, and safety in rosacea would include azelaic acid and ivermectin. 41,42,[44][45][46][47][48][49] Sub-antibiotic dose doxycycline (such as the modified-release 40 mg capsule once daily or 20 mg immediate-release tablet twice daily) provides anti-inflammatory effects with efficacy and favorable safety for rosacea, without inducing antibiotic selection pressure. 40,[44][45][46][47]50 …”

Section: -29 (3) Management Of Rosacea Does Not Require An Antibiotmentioning

confidence: 99%

Antibiotic Resistance Considerations of Importance to Clinical Dermatologists

Rosso

2017

J of Skin

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Antibiotic resistance is a major health concern worldwide as the list of bacterial pathogens that are insensitive to available antibiotics continues to grow in both hospitals and outpatient communities. The slow development of newer antibiotics adds to the formidable challenge that clinicians face with treatment of infections caused by antibiotic-resistant bacteria. This article discusses important caveats related to antibiotic use in dermatology. These include understanding that both topical and oral antibiotics contribute to the emergence and spread of resistant bacteria, that antibiotic monotherapy is to be avoided for treatment of acne vulgaris, that effective treatment of rosacea does not require the use of an antibiotic, that antibiotic therapy in the management of atopic dermatitis is best limited to treatment of an active clinical infection, and that routine post-operative use of a topical antibiotic is not suggested after most office-based dermatologic procedures. By following principles of antibiotic stewardship, dermatologists are major players in the battle against antibiotic resistance.

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“…Clinical Caveats Related to Antibiotic Use in Dermatology3,[11][12][13][14]16,17,19,20,26,[44][45][46][47][48][49][50][51][52][53][54][55][56][58][59][60] …”

mentioning

confidence: 99%

Antibiotic Resistance Considerations of Importance to Clinical Dermatologists

Rosso

2017

J of Skin

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The topic of antibiotic resistance has gained progressive attention globally in the lay press, in the medical literature, and among several organizations who are actively promoting antibiotic stewardship in the United States (US) and many other countries. 1-10 In fact, many countries, such as in Europe, have preceded the US in strongly promoting initiatives to limit antibiotic prescribing over the past few decades due to concerns related to the consequences of widespread antibiotic resistance and the slow development of new antibiotics. 1-3,8,9 In the US and within the specialty of dermatology, The Scientific Panel on Antibiotic Use in Dermatology (SPAUD), a project administered by the American Acne & Rosacea Society (AARS), has been evaluating antibiotic use within the dermatology specialty since 2005 and has provided educational initiatives and publications related to the subject of bacterial resistance to antibiotics and optimal antibiotic prescribing. 2,3,11-15 Several leading dermatologists with strong clinical and academic interest in ABSTRACT Antibiotic resistance is a major health concern worldwide as the list of bacterial pathogens that are insensitive to available antibiotics continues to grow in both hospitals and outpatient communities. The slow development of newer antibiotics adds to the formidable challenge that clinicians face with treatment of infections caused by antibiotic-resistant bacteria. This article discusses important caveats related to antibiotic use in dermatology. These include understanding that both topical and oral antibiotics contribute to the emergence and spread of resistant bacteria, that antibiotic monotherapy is to be avoided for treatment of acne vulgaris, that effective treatment of rosacea does not require the use of an antibiotic, that antibiotic therapy in the management of atopic dermatitis is best limited to treatment of an active clinical infection, and that routine post-operative use of a topical antibiotic is not suggested after most office-based dermatologic procedures. By following principles of antibiotic stewardship, dermatologists are major players in the battle against antibiotic resistance.

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Rosacea: a clinical review

Cited by 30 publications

References 28 publications

A case-control study on rosacea and vitamin D levels

A case-control study on rosacea and vitamin D levels

Antibiotic Resistance Considerations of Importance to Clinical Dermatologists

Antibiotic Resistance Considerations of Importance to Clinical Dermatologists

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