Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease

Rivas-García, Lorenzo; Quiles, José L.; Roma‐Rodrigues, Catarina; Raposo, Luís R.; Navarro-Hortal, María D.; Romero-Márquez, Jose M.; Esteban-Muñoz, Adelaida; Varela‐López, Alfonso; García, Laura Carrera; Cianciosi, Danila; Forbes-Hernández, Tamara Y.; Battino, Maurizio; Llopis, Juan; Fernandes, Alexandra R.; Baptista, Pedro V.; Sánchez-González, Cristina

doi:10.1016/j.fct.2021.112018

Cited by 12 publications

(17 citation statements)

References 37 publications

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“…Earlier studies showed that the rose petal extract can suppress MMP-9 expression and migration and invasion of vascular smooth muscle cells (VSMC) and some cancer cells. 41,43,44 Similarly, it was demonstrated that the rose petal extract inhibited the binding activity of transcription factors in VSMCs. 41 However, the present study suggests the first regulatory mechanism demonstrating inhibition of migration and invasion of cancer cells induced by reduced transcription factor-mediated MMP-9 expression.…”

Section: Discussionmentioning

confidence: 94%

“…[38][39][40][41][42] It has been revealed that RH petals may suppress the proliferation of several cancer cell lines in vitro. 43,44 However, the potential molecular mechanisms of antitumor effects by RH petals in vitro and in vivo have not been reported. Therefore, we investigated the precise action mechanisms of antitumor effects and angiogenesis inhibition effects of the RH extracts in bladder cancer using both in vitro experiments and in vivo mouse model.…”

Section: Introductionmentioning

confidence: 99%

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Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro

et al. 2022

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The edible Rosa hybrida (RH) petal is utilized in functional foods and cosmetics. Although the biological function of RH petal extract is known, mechanism of action studies involving tumor-associated angiogenesis have not yet been reported. Herein, we investigated the regulatory effect of the ethanol extract of RH petal (EERH) on tumor growth and tumor angiogenesis against bladder cancer. EERH treatment inhibited the bladder carcinoma T24 cell and 5637 cell proliferation because of G1-phase cell cycle arrest by inducing p21WAF1 expression and reducing cyclins/CDKs level. EERH regulated signaling pathways differently in both cells. EERH-stimulated suppression of T24 and 5637 cell migration and invasion was associated with the decline in transcription factor-mediated MMP-9 expression. EERH oral administration to xenograft mice reduced tumor growth. Furthermore, no obvious toxicity was observed in acute toxicity test. Decreased CD31 levels in EERH-treated tumor tissues led to examine the angiogenic response. EERH alleviated VEGF-stimulated tube formation and proliferation by downregulating the VEGFR2/eNOS/AKT/ERK1/2 cascade in HUVECs. EERH impeded migration and invasion of VEGF-induced HUVECs, which is attributed to the repressed MMP-2 expression. Suppression of neo-microvessel sprouting, induced by VEGF, was verified by treatment with EERH using the ex vivo aortic ring assay. Finally, kaempferol was identified as the main active compound of EERH. The present study demonstrated that EERH may aid the development of antitumor agents against bladder cancer.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro

et al. 2022

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“…These included maple syrup [ 111 ], fruits such as strawberry (Fragaria × ananassa ) [ 112 ], pomegranate ( Punica granatum L.) [ 113 , 114 ], guarana ( Paullinia cupana Kunth) [ 115 ] and cranberry ( Vaccinium ) [ 116 ], and spices such as holy basil ( Ocimum sanctum ) [ 117 ] and turmeric ( Curcuma longa L.) [ 114 ]. Other tested natural products were the extracts of flowers such as red rose ( Rosa x hybrida ) [ 118 ], roselle ( Hibiscus sabdariffa L.) [ 119 ], horned violet ( Viola cornuta ), and pansy ( Viola x wittrockiana ) [ 120 ]; essential oils from Kushui rose ( Rosa setate × Rosa rugosa ) [ 121 ]; Japanese zelkova ( Zelkova serrata (Thunb.) Makino) [ 122 ]; the brown macroalga Padina gymnospora (Kütz.)…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

“…Most of the tested products showed protective effects on the phenotype of the mentioned strains (i.e., they delayed paralysis induced by Aβ toxicity or reduced the number of paralyzed worms), except for pomegranate [ 114 ] and red rose extract [ 118 ]. In the same sense, other researchers reported the increased survival or lifespan of CL2006 nematodes when they were treated with ferulic acid, quercetin, gossypol, morin [ 140 ], caffeine, yerba mate extract [ 110 ], oleuropein aglycone [ 135 ] and otophylloside B [ 138 ].…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

“…Other authors have reported that sensitivity to exogenous serotonin was improved by ferulic acid [ 146 ], caffeic acid [ 147 ], A. tatarinowii Schott oil [ 105 ], ginkgolide A [ 99 ], sesamin, sesamolin [ 134 ], Kushui rose essential oil and geraniol (both isolated from Kushui rose essential oil) [ 121 ] and β-citronellol [ 121 ]. However, red rose [ 118 ] extract, sesamol [ 134 ] and the rest of the compounds isolated from G. biloba leaf extract, ginkgolide B, C and J, bilobalide B and flavonoids [ 99 ] had no effect on chemotaxis.…”

Section: Effects Of Natural Products In Caenorhabditis Eleg...mentioning

confidence: 99%

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Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Navarro-Hortal¹,

Romero-Márquez²,

Osta³

et al. 2022

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Alzheimer’s disease (AD) is an age-dependent, progressive disorder affecting millions of people. Currently, the therapeutics for AD only treat the symptoms. Although they have been used to discover new products of interest for this disease, mammalian models used to investigate the molecular determinants of this disease are often prohibitively expensive, time-consuming and very complex. On the other hand, cell cultures lack the organism complexity involved in AD. Given the highly conserved neurological pathways between mammals and invertebrates, Caenorhabditis elegans has emerged as a powerful tool for the investigation of the pathophysiology of human AD. Numerous models of both Tau- and Aβ-induced toxicity, the two prime components observed to correlate with AD pathology and the ease of performing RNA interference for any gene in the C. elegans genome, allow for the identification of multiple therapeutic targets. The effects of many natural products in main AD hallmarks using these models suggest promising health-promoting effects. However, the way in which they exert such effects is not entirely clear. One of the reasons is that various possible therapeutic targets have not been evaluated in many studies. The present review aims to explore shared therapeutical targets and the potential of each of them for AD treatment or prevention.

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Unravelling potential biomedical applications of the edible flower Tulbaghia violacea

et al. 2022

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Rosa x hybrida extracts with dual actions: Antiproliferative effects against tumour cells and inhibitor of Alzheimer disease

Cited by 12 publications

References 37 publications

Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro

Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro

Natural Bioactive Products and Alzheimer’s Disease Pathology: Lessons from Caenorhabditis elegans Transgenic Models

Unravelling potential biomedical applications of the edible flower Tulbaghia violacea

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