Unravelling potential biomedical applications of the edible flower Tulbaghia violacea

Rivas-García, Lorenzo; Romero-Márquez, Jose M.; Navarro-Hortal, María D.; Esteban-Muñoz, Adelaida; Giampieri, Francesca; Cano, Sandra; Battino, Maurizio; Quiles, José L.; Llopis, Juan; Sánchez-González, Cristina

doi:10.1016/j.foodchem.2022.132096

Cited by 12 publications

(15 citation statements)

References 37 publications

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“…This latter finding has been partly substantiated by data emerging from a study examining the antineoplastic properties of T. violacea against ovarian tumor cells. These extracts were shown to partially induce both apoptosis and necrosis with the most pronounced activity due to induction of autophagy [ 80 ].…”

Section: The Genus Tulbaghiamentioning

confidence: 99%

“…Tulbaghia has generated some interest on this front particularly as it is rich in compounds with proven antioxidant activity including phenols, tannins and flavonoids. Multiple studies have demonstrated that extracts of Tulbaghia have marked antioxidant activity as assessed using different assays in vitro including Trolox equivalent antioxidant capacity (TEAC; also commonly referred to as the ABTS assay), ferric-reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) ( Table 6 ) [ 58 , 80 , 90 , 91 ]. Furthermore, using an in vivo model of Caenorhabditis elegans , T. violacea extracts attenuated oxidative stress produced by a free radical generator, (2,2′-azobis-2-amidinopropane dihydrochloride; AAPH), in the roundworm [ 80 ].…”

Section: The Genus Tulbaghiamentioning

confidence: 99%

“…Multiple studies have demonstrated that extracts of Tulbaghia have marked antioxidant activity as assessed using different assays in vitro including Trolox equivalent antioxidant capacity (TEAC; also commonly referred to as the ABTS assay), ferric-reducing antioxidant power (FRAP) and 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) ( Table 6 ) [ 58 , 80 , 90 , 91 ]. Furthermore, using an in vivo model of Caenorhabditis elegans , T. violacea extracts attenuated oxidative stress produced by a free radical generator, (2,2′-azobis-2-amidinopropane dihydrochloride; AAPH), in the roundworm [ 80 ]. Data from these studies strongly suggested continued investigation of other species in the search for more potent antioxidant agents from Tulbaghia .…”

Section: The Genus Tulbaghiamentioning

confidence: 99%

“…In addition to diabetes and cardiovascular diseases, T. violacea has shown activity against another chronic condition, Alzheimer’s disease. In an in vivo Alzheimer’s disease transgenic C. elegans strain model, T. violacea significantly reduced 1-42 β-amyloid peptide formation ( Table 8 ) [ 80 ]. T. violacea exhibited in vivo anticonvulsant activity by attenuating tonic convulsions induced by either pentylenetetrazole, bicuculline, picrotoxin, strychnine or NMDLA [ 102 ] and validating its traditional use for the treatment of epilepsy.…”

Section: The Genus Tulbaghiamentioning

confidence: 99%

“…T. violaceaMethanol/water/formic acid (80:20:0.1, v/v/v) Flowers Reduced 1-42 β-amyloid peptide formation and arrested oxidative stress in vivo [80]. …”

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confidence: 99%

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The Phytochemistry and Pharmacology of Tulbaghia, Allium, Crinum and Cyrtanthus: ‘Talented’ Taxa from the Amaryllidaceae

et al. 2022

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Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antioxidant, antimicrobial, and immunomodulatory effects. Traditionally, natural products from Amaryllidaceae are utilized to treat non-communicable and infectious human diseases. Galanthamine, a drug from this family, is clinically relevant in treating the neurocognitive disorder, Alzheimer’s disease, which underscores the importance of the Amaryllidaceae alkaloids. Although Amaryllidaceae provide a plethora of biologically active compounds, there is tardiness in their development into clinically pliable medicines. Other genera, including Cyrtanthus and Tulbaghia, have received little attention as potential sources of promising drug candidates. Given the reciprocal relationship of the increasing burden of human diseases and limited availability of medicinal therapies, more rapid drug discovery and development are desirable. To expedite clinically relevant drug development, we present here evidence on bioactive compounds from the genera Allium, Tulgbaghia, Cyrtanthus and Crinum and describe their traditional and pharmacological applications.

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Section: The Genus Tulbaghiamentioning

confidence: 99%

Section: The Genus Tulbaghiamentioning

confidence: 99%

Section: The Genus Tulbaghiamentioning

confidence: 99%

Section: The Genus Tulbaghiamentioning

confidence: 99%

“…T. violaceaMethanol/water/formic acid (80:20:0.1, v/v/v) Flowers Reduced 1-42 β-amyloid peptide formation and arrested oxidative stress in vivo [80]. …”

mentioning

confidence: 99%

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