Rosa damascena restrains Plasmodium falciparum progression in vitro and impedes malaria pathogenesis in murine model

Khare, Sonam; Gupta, Madhuri; Cheema, Harveer Singh; Maurya, Anil Kumar; Rout, Prasanta Kumar; Darokar, Mahendra P.; Pal, Anirban

doi:10.1016/j.biopha.2017.11.130

Cited by 11 publications

(5 citation statements)

References 26 publications

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“…Quercetin and kaempferol were the main flavonols detected in the fresh flower petal extracts of the nine R. damascena genotypes, with quercetin present at relatively higher amounts than kaempferol, which is consistent with the report of Mohsen et al [6]. The range of concentrations for quercetin in this study was from 0.36 to 1.17 µg/g, relatively lower than the concentration of 4.416 µg/mL reported by Khare et al [38], which was probably due to the dried flower petals used and the different basis of calculation.…”

Section: Non-volatile Substances Analysis With Lc-mssupporting

confidence: 92%

“…In addition to these, the yield and composition of rose oil are also influenced by the stage of development of the flowers, the date and time of harvest, storage and processing, as well as the distillation process [14,[32][33][34][35][36][37]. The chemical components of the essential oils that give them their characteristic aroma and medicinal properties are alcohols (2-phenylethylalcohol, geraniol, nerol and citronellol), aldehydes, ketones, phenols, acids and esters, whereas hydrocarbons (nonadecane) do not participate in the above properties [6,13,38,39]. It has been reported that the lower the level of hydrocarbons, the better the quality of rose oil obtained and their role lies in the stability of the aroma of the essential oil [6].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Assessment, Propagation and Chemical Analysis of Flowers of Rosa damascena Mill. Genotypes Cultivated in Greece

Ziogou,

Kotoula,

Hatzilazarou

et al. 2023

Horticulturae

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Rosa damascena Mill. is commercially the most important rose species used to produce essential oils. The plants of this species, cultivated in the district of Western Macedonia (Greece) for rose oil production, originated from indigenous genotypes but also nurseries abroad, mainly from Bulgaria. The present study investigated the genetic relationship between nine genotypes of R. damascena from Greece, one genotype from Turkey, three genotypes from Bulgaria and three genotypes from France using the molecular markers ISSR and SCoT. Also, the rooting ability of shoot cuttings from these nine genotypes was investigated by applying 2 g/L of the rooting regulator K-IBA. In addition, petals were chemically analyzed using GC-MS and LC-MS to identify the compounds that are the main components of the rose oil. The nine rose genotypes of R. damascena, cultivated in Greece, one from Turkey and one of the three genotypes from Bulgaria were clustered in one clade in the dendrogram. The other two genotypes from Bulgaria were clustered in a separate clade that demonstrated the existence of genetic diversity among the three Bulgarian genotypes, while the French genotypes were clustered in a third clade. The shoot cuttings rooted relatively easily (55–70%) with the application of K-IBA, without any significant differences among the nine genotypes. Large variation was observed among the nine genotypes in the main volatile compounds of the flower petal extracts, which are related to rose oil components. For these compounds, the concentrations in μg/g of the fresh petal weight were 2-phenylethylalcohol (1148.35–2777.19), nerol (27.45–64.93), citronellol (88.45–206.59), geraniol (69.12–170.99) and nonadecane (209.27–533.15). Of the non-volatile compounds, gallic acid was the most abundant phenolic acid in the petal extracts of the nine genotypes (0.28–0.82 μg/g), while for the flavonoids, quercetin and kaempferol variations of 0.35–1.17 μg/g and 0.26–2.13 μg/g were recorded, respectively.

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Section: Non-volatile Substances Analysis With Lc-mssupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Genetic Assessment, Propagation and Chemical Analysis of Flowers of Rosa damascena Mill. Genotypes Cultivated in Greece

Ziogou,

Kotoula,

Hatzilazarou

et al. 2023

Horticulturae

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“…Briefly, serum from the experimental animals was used for measurement of alkaline phosphatase (ALP), serum glutamic oxaloacetic transaminase (SGOT), and total bilirubin using kits of the standard protocols. 40,[42][43][44] Additionally, in the same experiment, serum was derived from the blood of experimental animals collected at the peak parasitemia on day 8. The inflammatory mediators (cytokines) were quantified using mouse-specific ELISA kits (BD biosciences, USA) per manufacturer instructions.…”

Section: Biochemical Liver Function Test and Inflammatory Mediators U...mentioning

confidence: 99%

Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in Plasmodium falciparum

Kapkoti

Kumar

et al. 2023

New J. Chem.

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“…In vivo antimalarial activity of 4-chlorothymol and combination (4-chlorothymol and chloroquine) was evaluated using Swiss albino mice (5mice/group) against Plasmodium yoelii nigeriensis (chloroquine-resistant rodent malaria strain) (Khare et al, 2018). 4-Chlorothymol was suspended in 0.7% CMC (carboxy methyl cellulose), which was administered orally to the experimental animals 1 h after infection at doses 25 mg/kg, 50 mg/kg, and 100 mg/kg body weight for 7 days consecutively.…”

Section: In Vivo Antimalarial Activitymentioning

confidence: 99%

4-Chlorothymol Exerts Antiplasmodial Activity Impeding Redox Defense System in Plasmodium falciparum

et al. 2021

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Malaria remains one of the major health concerns due to the resistance of Plasmodium species toward the existing drugs warranting an urgent need for new antimalarials. Thymol derivatives were known to exhibit enhanced antimicrobial activities; however, no reports were found against Plasmodium spp. In the present study, the antiplasmodial activity of thymol derivatives was evaluated against chloroquine-sensitive (NF-54) and -resistant (K1) strains of Plasmodium falciparum. Among the thymol derivatives tested, 4-chlorothymol showed potential activity against sensitive and resistant strains of P. falciparum. 4-Chlorothymol was found to increase the reactive oxygen species and reactive nitrogen species level. Furthermore, 4-chlorothymol could perturb the redox balance by modulating the enzyme activity of GST and GR. 4-Chlorothymol also showed synergy with chloroquine against chloroquine-resistant P. falciparum. 4-Chlorothymol was found to significantly suppress the parasitemia and increase the mean survival time in in vivo assays. Interestingly, in in vivo assay, 4-chlorothymol in combination with chloroquine showed higher chemosuppression as well as enhanced mean survival time at a much lower concentration as compared to individual doses of chloroquine and 4-chlorothymol. These observations clearly indicate the potential use of 4-chlorothymol as an antimalarial agent, which may also be effective in combination with the existing antiplasmodial drugs against chloroquine-resistant P. falciparum infection. In vitro cytotoxicity/hemolytic assay evidently suggests that 4-chlorothymol is safe for further exploration of its therapeutic properties.

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Rosa damascena restrains Plasmodium falciparum progression in vitro and impedes malaria pathogenesis in murine model

Cited by 11 publications

References 26 publications

Genetic Assessment, Propagation and Chemical Analysis of Flowers of Rosa damascena Mill. Genotypes Cultivated in Greece

Genetic Assessment, Propagation and Chemical Analysis of Flowers of Rosa damascena Mill. Genotypes Cultivated in Greece

Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in Plasmodium falciparum

4-Chlorothymol Exerts Antiplasmodial Activity Impeding Redox Defense System in Plasmodium falciparum

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