Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in <i>Plasmodium falciparum</i>

Kapkoti, Deepak Singh; Kumar, Sunil; Kumar, Ashish; Darokar, Mahendra P.; Pal, Anirban; Bhakuni, R. S.

doi:10.1039/d2nj05302k

New J. Chem.

2023

DOI: 10.1039/d2nj05302k

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Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in Plasmodium falciparum

Deepak Singh Kapkoti

Sunil Kumar

Ashish Kumar

et al.

Abstract: Malaria is an enormous threat to public health due to the emergence of Plasmodium falciparum resistance to widely used anti-malarials, such as chloroquine. Besides, the resistance commercially used antimalarial drugs...

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Cited by 4 publications

References 77 publications

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Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal

Bagratee,

Prawlall,

Ndlovu

et al. 2024

Chemistry & Biodiversity

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Malaria is a very destructive and lethal parasitic disease that causes significant mortality worldwide, resulting in the loss of millions of lives annually. The uncontrolled intake of antimalarial drugs often employed in clinical settings has resulted in the emergence of numerous strains of plasmodium that are resistant to these drugs, including multidrug‐resistant strains. Hence, there is an urgent need for developing unique classes of antimalarial drugs that function with distinct mechanisms of action. In this context, the design and development of hybrid compounds that combine pharmacophoric properties from different lead molecules into a single unit gives a unique perspective towards further development of malaria drugs in the next generation. In light of this, we have reviewed the progress of hybrid antimalarial agents from 2021 up to the present. This manuscript presents a comprehensive overview of the latest advancements in the medicinal chemistry pertaining to small molecules, with a specific focus on their potential as antimalarial agents. This review explores a variety of physiologically active compounds that have been described in the literature in order to lay a strong foundation for the logical design and eventual identification of antimalarial drugs based on lead frameworks.

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Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal

Bagratee,

Prawlall,

Ndlovu

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review

Li,

Lu,

Wang

et al. 2024

Mol Divers

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Triazole hybrid compounds: A new frontier in malaria treatment

Ravindar

Hasbullah

Rakesh

et al. 2023

European Journal of Medicinal Chemistry

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Design and synthesis of novel glycyrrhetinic acid-triazole derivatives that exert anti-plasmodial activity inducing mitochondrial-dependent apoptosis in Plasmodium falciparum

Abstract: Malaria is an enormous threat to public health due to the emergence of Plasmodium falciparum resistance to widely used anti-malarials, such as chloroquine. Besides, the resistance commercially used antimalarial drugs...

Cited by 4 publications

References 77 publications

Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal

Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal

Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review

Triazole hybrid compounds: A new frontier in malaria treatment

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