Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy–results from a double-blind, randomized, placebo-controlled clinical trial

Farnia, Vahid; Tatari, Faezeh; Alikhani, Mostafa; Shakeri, Jalal; Taghizadeh, Moshen; Karbasizadeh, Hassan; Bahmani, Dena Sadeghi; Holsboer‐Trachsler, Edith; Brand, Serge

doi:10.1016/j.drugalcdep.2017.02.008

Cited by 19 publications

(29 citation statements)

References 38 publications

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“…This mixture improves uterus function and excretes bad secretions of the uterus. Different studies approved the effect of R. damascena and honey on the treatment of dermatologic diseases (38) and vaginal problems (39)(40)(41). In addition, sitting in a mixture of Althaea officinalis, Malva neglecta, and Linum usitatissimum was prescribed, which helps to remove the inflammation of uterus and its dystemperament.…”

Section: Discussionmentioning

confidence: 99%

Management of Early Menopause Using Traditional Persian Medicine: A Case Report

Behnoud

Bahrami

Kordafshari

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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Interruption of the activity of ovary before the age of forty is called premature ovarian failure (POF) in which ovaries lose their follicular and hormonal functions. A decline in the number of ovules before the age of menopause is a physiologic phenomenon. In the present case report, treatment of a patient by POF was reported using traditional Persian medicine principles. In Persian medicine, each humor has its own temperament. A change in the temperament and quality or quantity of these humors causes the disease and therefore modifying the temperament is the milestone of treatment. The patient was a 39-year-old married woman with irregular menstruation cycles and finally, cessation of menstruation. In this period, the patient had vaginal dryness, severe dyspareunia, gastritis, and parasomnia. At first, some instructions were ordered to change her lifestyle, for example, a change in food intakes, enough sleep, and exercise. In addition, several medications were ordered including the digestive system electuary (Majoun Jahaz Hazemeh), Eyaraj Fighara capsule and powder containing Glycyrrhiza glabra roots, Foeniculum vulgare and white sugar, oil massage of the abdomen and flanks, and cupping of the uterus. At the end of treatment, complete rehabilitation was achieved and menstruation irregularity, gastritis, and parasomnia were resolved. Based on the results, if a patient follows the rules and has a healthy lifestyle, inappropriate humor is unable to appear, the healing can be stable, and this disease or similar melancholic disorders fail to occur

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Section: Discussionmentioning

confidence: 99%

Management of Early Menopause Using Traditional Persian Medicine: A Case Report

Behnoud

Bahrami

Kordafshari

et al. 2018

International Journal of Women’s Health and Reproduction Scienc

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“…Due to the difference in terms of the pathophysiology of sexual dysfunction, the treatment option of sexual dysfunction in the OST population is different from the other population. Antidepressants such as bupropion and trazodone and herbal alternatives such as rosa Damascena and ginseng have been reported to significantly improve OST patients with sexual dysfunction [8,[22][23][24][25][26][27]. Although various clinical studies and reviews have explored the role of intervention for sexual dysfunction in many conditions, such as diabetes, stroke, and cancer population, the effectiveness and safety of sexual dysfunction intervention in the OST population has not been studied thoroughly [28][29][30].…”

Section: Ivyspringmentioning

confidence: 99%

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis

2021

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Sexual dysfunction is a common condition in the opioid substitution therapy (OST) population. We aimed to determine the efficacy and safety of treatment for sexual dysfunction in the OST population. We searched for interventional studies from Medline, PubMed, and Scopus. Three independent authors conducted a risk-of-bias assessment (RoB 2). A total of seven studies (five randomized-controlled trials, two quasi-experimental), including 473 patients with sexual dysfunction, were identified. Among these, three bupropion (n=207), one trazodone (n=75), two rosa Damascena (n=100), and one ginseng (n=91) studies had reported significantly improve various sexual functioning domains in both genders. In a meta-analysis, bupropion significantly increased male sexual function with standardized mean difference of 0.53; 95% confidence interval of 0.19-0.88; P < 0.01; I 2 =0. The adverse effects were minor for all agents, and no significant difference between treatment and placebo groups in randomized-controlled trials. These agents have a promising future as therapy for sexual dysfunction in the OST population. However, given the limited sample size and number of studies, further studies should be conducted to confirm the use of these agents.

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“…In addition, recently, it has been reported that Rosa damascena oil had an improvement effect on sexual function in patients under SSRI treatment, methadone treatment for opium use disorder. [67][68][69][70] Psychosocial approaches particularly cognitive-behavioral therapy (CBT) may be utilized in an antidepressant-induced sexual dysfunction. Whereas the CBT is widely used in a variety of psychiatric disorders, the limited number of investigations has been in antidepressant-associated sexual dysfunction.…”

Section: Management Of Ssri-induced Sexual Dysfunctionmentioning

confidence: 99%

<p>Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives</p>

Atmaca¹

2020

NDT

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Any type of sexual dysfunction is an important problem in half of the patients with depressive disorder. On the other hand, one to a quarter of people without any depressive disorder experience sexual dysfunction. Antidepressant agents can lead to all types of sexual side effects including arousal, libido, orgasm and ejaculation problems. Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drugs which are prescribed for the treatment of a variety of disorders, including major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, generalized anxiety disorder, and impulse control disorders. It has been reported that one in eight people have utilized one of the SSRIs in the past 10 years. Some studies reported up to 80% of SSRI-induced sexual side effects. Management of SSRI-induced sexual dysfunction seems to be complex and hard. In this paper, SSRIinduced sexual dysfunction and new perspectives in the management of this problem were reviewed.

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Rosa Damascena oil improved sexual function and testosterone in male patients with opium use disorder under methadone maintenance therapy–results from a double-blind, randomized, placebo-controlled clinical trial

Cited by 19 publications

References 38 publications

Management of Early Menopause Using Traditional Persian Medicine: A Case Report

Management of Early Menopause Using Traditional Persian Medicine: A Case Report

Treatments of Sexual Dysfunction in Opioid Substitution Therapy Patients: A Systematic Review and Meta-Analysis

<p>Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives</p>

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