<p>Selective Serotonin Reuptake Inhibitor-Induced Sexual Dysfunction: Current Management Perspectives</p>

Abstract

Any type of sexual dysfunction is an important problem in half of the patients with depressive disorder. On the other hand, one to a quarter of people without any depressive disorder experience sexual dysfunction. Antidepressant agents can lead to all types of sexual side effects including arousal, libido, orgasm and ejaculation problems. Selective serotonin reuptake inhibitors (SSRIs) are a widely used class of drugs which are prescribed for the treatment of a variety of disorders, including major depressive disorder, obsessive-compulsive disorder, posttraumatic stress disorder, panic disorder, generalized anxiety disorder, and impulse control disorders. It has been reported that one in eight people have utilized one of the SSRIs in the past 10 years. Some studies reported up to 80% of SSRI-induced sexual side effects. Management of SSRI-induced sexual dysfunction seems to be complex and hard. In this paper, SSRIinduced sexual dysfunction and new perspectives in the management of this problem were reviewed.

Saikosaponin D Rescues Deficits in Sexual Behavior and Ameliorates Neurological Dysfunction in Mice Exposed to Chronic Mild Stress

“…Mood disorders, such as depression, are mainly caused by chronic stress or stressful events, with a high lifetime prevalence of reaching 20% ( Patten, 2003 ). Sexual dysfunction, characterized by decreased sexual motivation and impaired sexual performance, is a major comorbidity in men with depression ( Clayton et al, 2013 ) and current therapies are only partially effective, with a slow onset of efficacy, and may even lead to more severe sexual dysfunction ( Atmaca, 2020 ). In the present study, we found that treatment with SSD can not only generate a stable antidepressant effect but also significantly alleviate sexual dysfunctions in CMS mice.…”

The Importance of a Multi-Disciplinary Approach to the Endometriotic Patients: The Relationship between Endometriosis and Psychic Vulnerability

“…As might be expected, male partners suffer too from the consequences of the partner’s discomfort, showing increased rates of psychological distress, with a higher prevalence of sexual difficulties (e.g., erectile dysfunction), and less sexual satisfaction [ 205 , 206 , 207 , 208 ]. At the same time, it should never be overlooked that psychopharmacological therapy as well as hormone therapy can in their turn affect the sexual activity of women who have endometriosis [ 209 , 210 , 211 ]. It follows that gynecological and pain management treatment cannot be separated from a scrupulous psychiatric assessment in terms of clinical efficacy and prognosis.…”

Management of hypoactive sexual desire disorder in women in the gynecological setting

“…(22) Follow-up with a psychiatrist together with a gynecologist is highly recommended. (23) The management of sexual dysfunction induced by serotonin reuptake inhibitors may include discussing the possibility of adding/changing medication by the psychiatrist (Chart 2). ity may lead to contraceptive discontinuation.…”