ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo

Yao, Yingming; Ding, Jie; Wang, Zhaoyi; Zhang, Haolan; Xie, Jieqi; Wang, Yingchao; Ling, Hong; Mao, Zhengwei; J, Gao; Gao, Changyou

doi:10.1016/j.biomaterials.2019.119726

Cited by 100 publications

(87 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS-responsive microspheres were further prepared using this polymer for inflammation-triggered local delivery of tacrolimus, a powerful immunosuppressant. Gao et al synthesized ROS-responsive and biodegradable polyurethane by reaction of poly(ε-caprolactone) diol, 1,6-hexamethylene diisocyanate, and a thioketal-containing chain extender, which was fabricated into fibrous patches for therapeutic delivery [ 233 ]. Wang’s group reported a thioketal linkage-bridged diblock copolymer of PEG and PLA for on-demand drug delivery [ 234 ].…”

Section: Materials and Delivery Vehicles Responsive To Inflammatory Smentioning

confidence: 99%

“…In a rat model of myocardial ischemia-reperfusion injury, intramyocardial treatment with Rg3-loaded PEG-b-PPS nanoparticles significantly decreased the plasma levels of TNF-α, interleukin (IL)-1β, IL-6, and C-reactive protein (CRP), therefore resulting in notably improved cardiac function and reduced the infarct size [ 247 ]. In addition, fibrous patches based on polyurethane containing thioketal linkages were used as a ROS-responsive delivery platform of methylprednisolone, showing desirable effects with respect to free radical scavenging, rebuilding structures, and improving functions of infarcted myocardium after implantation in MI rats [ 233 ]. Also, captopril-loaded mesoporous silica nanoparticles of ~120 nm with H 2 O 2 -triggerable release performance were examined for therapy of heart failure in a zebrafish model [ 287 ].…”

Section: Treatment Of Inflammatory Diseases By Bioresponsive Drug Delmentioning

confidence: 99%

See 1 more Smart Citation

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Ding

et al. 2020

Journal of Controlled Release

121

View full text Add to dashboard Cite

Inflammation is intimately related to the pathogenesis of numerous acute and chronic diseases like cardiovascular disease, inflammatory bowel disease, rheumatoid arthritis, and neurodegenerative diseases. Therefore anti-inflammatory therapy is a very promising strategy for the prevention and treatment of these inflammatory diseases. To overcome the shortcomings of existing anti-inflammatory agents and their traditional formulations, such as nonspecific tissue distribution and uncontrolled drug release, bioresponsive drug delivery systems have received much attention in recent years. In this review, we first provide a brief introduction of the pathogenesis of inflammation, with an emphasis on representative inflammatory cells and mediators in inflammatory microenvironments that serve as pathological fundamentals for rational design of bioresponsive carriers. Then we discuss different materials and delivery systems responsive to inflammation-associated biochemical signals, such as pH, reactive oxygen species, and specific enzymes. Also, applications of various bioresponsive drug delivery systems in the treatment of typical acute and chronic inflammatory diseases are described. Finally, crucial challenges in the future development and clinical translation of bioresponsive anti-inflammatory drug delivery systems are highlighted.

show abstract

Section: Materials and Delivery Vehicles Responsive To Inflammatory Smentioning

confidence: 99%

Section: Treatment Of Inflammatory Diseases By Bioresponsive Drug Delmentioning

confidence: 99%

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Ding

et al. 2020

Journal of Controlled Release

121

View full text Add to dashboard Cite

show abstract

“…In particular, the ROS-responsive biomaterials play an important role in the tissue microenvironment and regeneration [ 182 ]. For example, implantation of thioketal- (PUTK-) based ROS-responsive polyurethane patches loaded with glucocorticoid methylprednisolone (MP) improved significantly the reconstruction of functions of the myocardium including elevated ejection fraction, reduced infarction size, and increased revascularization in MI rats [ 183 ].…”

Section: Chronic Inflammation-associated Diseases and Therapiesmentioning

confidence: 99%

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

et al. 2021

Self Cite

View full text Add to dashboard Cite

Tissue regeneration is an active multiplex process involving the dynamic inflammatory microenvironment. Under a normal physiological framework, inflammation is necessary for the systematic immunity including tissue repair and regeneration as well as returning to homeostasis. Inflammatory cellular response and metabolic mechanisms play key roles in the well-orchestrated tissue regeneration. If this response is dysregulated, it becomes chronic, which in turn causes progressive fibrosis, improper repair, and autoimmune disorders, ultimately leading to organ failure and death. Therefore, understanding of the complex inflammatory multiple player responses and their cellular metabolisms facilitates the latest insights and brings novel therapeutic methods for early diseases and modern health challenges. This review discusses the recent advances in molecular interactions of immune cells, controlled shift of pro- to anti-inflammation, reparative inflammatory metabolisms in tissue regeneration, controlling of an unfavorable microenvironment, dysregulated inflammatory diseases, and emerging therapeutic strategies including the use of biomaterials, which expand therapeutic views and briefly denote important gaps that are still prevailing.

show abstract

“…The radical scavenging potential of PE-UR and PTK-UR scaffolds was assessed through using 1,1diphenyl-2-picrylhydrazyl (DPPH) assay (37). DPPH was dissolved in a mixture of 80:20 ethanol/H2O…”

Section: Dpph Radical Scavenging Assaymentioning

confidence: 99%

ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair

Patil

Russo

McCune

et al. 2021

Preprint

View full text Add to dashboard Cite

Impaired skin healing and progression into chronic wounds is a prevalent and growing medical problem. Porous, resorbable biomaterials can be used as temporary substrates placed into skin defects to support cell infiltration, neo-tissue formation, and remodeling of nonhealing wounds. Naturally-derived biomaterials have promising healing benefits, but their low mechanical properties and exuberant costs limit their performance and use. Synthetic materials can be affordably manufactured and tuned across a broader range of physiochemical properties, but opportunities remain for tailoring them for ideal host immune and regenerative responses. Polyesters are the most clinically-tested class of synthetic biomaterials, but their hydrolysis releases acidic degradation products that can cause autocatalytic degradation processes that are poorly controlled and are not tied to cellular or other biologic activities. Here, we systemically explored a series of ROS-degradable polythioketal (PTK) urethane (UR) foams with varied hydrophilicity as an alternative class of synthetic biomaterials for wound healing. It was found that the most hydrophilic PTK-UR variant, which had 7 ethylene glycol (EG7) repeats flanking each side of each thioketal bond, had the highest ROS reactivity of the PTK-URs tested. In an in vivo porcine excisional skin wound healing model, hydrophilic EG7 PTK-UR foams more effectively promoted tissue integration, ECM deposition, and re-epithelialization of full-thickness skin wound compared to more hydrophobic PTK-UR variants. Resolution of type 1 inflammation and lower foreign body response to scaffold remnants was also observed for EG7 versus more hydrophobic PTK-UR scaffolds. Finally, porcine wound healing studies showed that EG7 PTK-UR foams had similar wound healing response to a collagen-based clinical gold standard product, Integra Bilayer Wound Matrix (BWM), while outperforming polyester UR foam-based NovoSorb Biodegradable Temporizing Matrix (BTM) with respect to increased ECM production, vascularization, and biomaterial-associated immune phenotype. In sum, PTK-UR foams warrant further development toward a new class of synthetic biomaterial foams for skin wound healing applications.

show abstract

ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo

Cited by 100 publications

References 74 publications

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

The Dynamic Inflammatory Tissue Microenvironment: Signality and Disease Therapy by Biomaterials

ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair

Contact Info

Product

Resources

About