ROS-responsive nanoparticles for oral delivery of luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment

Tan, Chen; Fan, Huiying; Ding, Jiahui; Han, Chaoqun; Guan, Yang; Zhu, Feng; Wu, Hui; Liu, Yujin; Zhang, Wei; Hou, Xiaohua; Tan, Songwei; Tang, Qing

doi:10.1016/j.mtbio.2022.100246

Cited by 39 publications

(36 citation statements)

References 63 publications

(83 reference statements)

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“…Studies have shown that oxidative stress is another important inflammatory inducer in UC. Indeed, oxidative stress can affect the onset, development, deterioration, and recurrence of various intestinal inflammatory diseases by destroying essential cellular molecules, such as lipids, proteins, and DNA. , As it has been reported that RH can improve the effect of UC through antioxidative stress, we next investigated the activities of oxidative stress markers (MDA, SOD, GSH-PX) in the colon tissue of each group (Figure A). According to the results, compared to the control group, the activities of GSH-PX and SOD were decreased in the colon tissue of the UC model group, while the level of MDA was increased, indicating significant oxidative damage ( p < 0.05).…”

Section: Results and Discussionmentioning

confidence: 99%

pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

Luo

Han

et al. 2022

ACS Appl. Mater. Interfaces

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Rhein (RH), a natural anthraquinone compound, is considered an effective treatment candidate for ulcerative colitis (UC), whose multiple biological activities contribute to UC, including anti-inflammation, antioxidation, intestinal barrier repair, and microflora regulation. However, the application of RH is severely limited by its low water solubility, low bioavailability, and poor colonic targeting. Although some nanoparticles have been developed for the oral delivery of RH, most of them mainly highlighted only one effect of some drug delivery strategies but the above multiple biological activities. Therefore, a multiple polysaccharide-based nanodelivery system, comprising chitosan (CS) and fucoidan (FU), with pH/reactive oxygen species (ROS) sensitivity and mucosal adhesion, was developed and first used to load RH as a comprehensive treatment for UC. Briefly, RH-F/C-NPs were prepared using the polyelectrolyte self-assembly method; the average size of RH-F/C-NPs was 233.1 ± 5.7 nm, and the encapsulation rate of RH was 93.67 ± 1.60%. And it could maintain gastric stability and release RH in the colon with the designed pH/ROS sensitivity contributed by the polysaccharide-based structures. Cellular uptake experiments showed that both NCM 460 cells and RAW 264.7 cells had a good uptake of RH-F/C-NPs. Importantly, the effects of RH were highlighted in in vivo experiments, the results of which showed that RH-F/C-NPs could significantly reduce DSS-induced inflammation by inhibiting the TLR4/NF-κB-mediated anti-inflammatory pathway, the Nrf2/HO-1-mediated antioxidant pathway, colonic mucosal barrier repair, and intestinal microflora regulation. In addition, pharmacokinetic studies have shown that F/C-NPs contribute to the increase in the plasma concentration and the accumulation of RH in the colon to some extent. In short, this study is the first to develop an oral multiple polysaccharide-based nanosystem with pH/ROS dual sensitivity to study the "one stone four birds" therapeutic effect of RH on UC.

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Section: Results and Discussionmentioning

confidence: 99%

pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

Luo

Han

et al. 2022

ACS Appl. Mater. Interfaces

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“…Luteolin (LUT) is a natural flavonoid with good antioxidant activity, free radical scavenging ability, anti-inflammatory activity and the ability to regulate intestinal flora. C. Tan et al 63 synthesized a novel ROS-responsive thioether copolymer TPGS-PBTE, and subsequently loaded LUTs into TPGS-PBTE. The formed LUT-encapsulated NPs could selectively degrade in response to excessive ROS.…”

Section: Research Status Of Micro/nanoparticles In the Treatment Of Ibdmentioning

confidence: 99%

The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

Zhou

Feng

et al. 2023

J. Mater. Chem. B

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“…As displayed in Table S2, Supporting Information, the researches using natural small molecules as therapeutic drugs for treating UC were also compared with this study. [76][77][78][79] It is clear that natural small molecules including such natural flavonoids as emodin, luteolin, and DHM can effectively treat UC with their anti-inflammatory function. Moreover, compared to previous studies, [74][75][76][77] the nanosystem BM@EP can achieve activatable imaging and biomarker-triggered drug release for both detection and therapy of UC.…”

Section: Treating Ulcerative Colitis and Tracking Therapeutic Effect ...mentioning

confidence: 99%

A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

Zeng

Ouyang

Sun

et al. 2022

Adv Healthcare Materials

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Ulcerative colitis (UC) is a prevalent idiopathic inflammatory disease which causes such complications as intestinal perforation, obstruction, and bleeding, and thus deleteriously impacting people's normal work and quality of life. Hence, accurate diagnosis of UC is crucial in terms of planning optimal treatment plan. Herein, a pH/reactive oxygen species (ROS) dual-responsive nanosystem (BM@EP) is developed for UC's detection and therapy. BM@EP is composed of a chromophore-drug dyad and the enteric coating. The chromophore-drug dyad (BOD-XT-DHM) is synthesized by linking the chromophore (BOD-XT-BOH) and a flavonoid drug (dihydromyricetin DHM) through boronate ester bond. The enteric coating includes Eudragit S100 and poly(lactic-co-glycolic acid) (PLGA), the former is commonly employed as a pH-dependent polymer coating excipient so as to attain colon-targeted delivery, and the latter has been widely used as an excipient for the controlled-extended release. After oral administration, BM@EP delivers the dyad (BOD-XT-DHM) into the colon and releases the dyad molecules by being triggered by the alkaline pH in t colon, thereafter upon being stimulated by overexpressed H 2 O 2 in the inflamed colon, the boronate bond in the dyad is broken down and correspondingly the drug DHM is released for UC therapy, simultaneously the chromophore is released for near-infrared second window (NIR-II) fluorescence and optoacoustic imaging for UC diagnosis and recovery evaluation.

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ROS-responsive nanoparticles for oral delivery of luteolin and targeted therapy of ulcerative colitis by regulating pathological microenvironment

Cited by 39 publications

References 63 publications

pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance “One Stone Four Birds” Effect of Rhein on Ulcerative Colitis

The application of natural product-delivering micro/nano systems in the treatment of inflammatory bowel disease

A Biomarker‐Responsive Nanosystem with Colon‐Targeted Delivery for Ulcerative Colitis's Detection and Treatment with Optoacoustic/NIR‐II Fluorescence Imaging

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