ROS‐Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Zhang, Yuqi; Feng, Peijian; Yu, Jicheng; Yang, Jincai; Zhao, Jiacheng; Wang, Jinqiang; Shen, Qun; Gu, Zhifeng

doi:10.1002/adtp.201870006

Cited by 7 publications

(10 citation statements)

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“…The major advantages of MN-mediated drug delivery are the ability to deliver drugs through a large surface area, administration feasibility [4][5][6][7], avoidance of first-pass metabolism and gastrointestinal degradation [8,9]. Drug delivery via the skin is useful either for releasing the drug into the layers of skin at the site of administration (e.g., skin abnormalities treatment and vaccination) known as dermal delivery [10,11], or by delivering the cargo systemically through the administration from the skin known as transdermal delivery (e.g., insulin therapy) [12,13].…”

Section: Introductionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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Transdermal microneedle (MN) patches are a promising tool used to transport a wide variety of active compounds into the skin. To serve as a substitute for common hypodermic needles, MNs must pierce the human stratum corneum (~ 10 to 20 µm), without rupturing or bending during penetration. This ensures that the cargo is released at the predetermined place and time. Therefore, the ability of MN patches to sufficiently pierce the skin is a crucial requirement. In the current review, the pain signal and its management during application of MNs and typical hypodermic needles are presented and compared. This is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical practice. Factors that affect insertion (e.g., geometry, material composition and cross-linking of MNs), along with recent advancements in developed strategies (e.g., insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography) to improve the skin penetration are highlighted to provide a backdrop for future research.

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Section: Introductionmentioning

confidence: 99%

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

et al. 2021

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“…The microneedles have been demonstrated to transport various therapeutic agents, from small molecules to nano/micro-particles, into the dermal or epidermis layers. , Manufacturing microneedle devices is cost-effective based on well-established and scalable micromolding techniques. For example, microneedles have been produced from a wide variety of material matrices, including metal, silicon, and biocompatible polymers for delivery of insulin, hormones, and vaccines. − However, metal and silicon microneedles eventually become sharp and biohazardous waste after uses, which poses serious immunogenic risks and environmental issues. , In contrast, microneedles made of biocompatible polymers enable drug loading in the needle matrix and spontaneous drug release after skin penetration via polymer swelling and dissolution, followed by degradation and excretion from physiological environments. − …”

Section: Introductionmentioning

confidence: 99%

Highly Porous Silk Fibroin Scaffold Packed in PEGDA/Sucrose Microneedles for Controllable Transdermal Drug Delivery

et al. 2019

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Polymeric microneedles have attracted increasing attention as a minimally invasive platform for delivering drugs or vaccines in a more patient-friendly manner. However, traditional microfabrication techniques using negative molds with needle-shaped cavities usually require cumbersome centrifugation and vacuum degassing processes, which have restricted the scaled-up mass production of polymeric microneedles. Herein, a novel polydimethylsiloxane (PDMS)-based negative mold with cavities packed with silk fibroin scaffold is developed for rapid fabrication of polymeric microneedles, which comprise primarily the composition of poly-(ethylene glycol) diacrylate (PEGDA) and sucrose as the needle matrix. Fibroin scaffolds can instantly adsorb prepolymer solution due to capillary force, and subsequently initiate the formation of microneedles via photoinduced polymerization. Based on three types of model drugs, including Rhodamine B (RhB), indocyanine green (ICG), and doxorubicin (DOX), the fabricated PEGDA/ sucrose microneedles can realize effective transdermal delivery and controllable release of therapeutic molecules by regulating the sucrose content. The presented method provides a simple strategy for quick fabrication of polymeric microneedles toward transdermal drug delivery applications.

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Section: Introductionmentioning

confidence: 99%

“…Intelligent stimulus‐response MNs, also known as “Smart MNs,” are a kind of precise method of medical therapy that can be accomplished under specific physiological conditions, external conditions, or in combination with a specific target. [ 11,20 ] Physical, chemical, and biological factors have been extensively applied to intelligent stimulus‐response MNs, which are induced by pH, [ 21 ] temperature, [ 22 ] magneti, [ 23 ] light, [ 24 ] enzyme, [ 25 ] reactive oxygen species, [ 26 ] electricity, [ 27 ] glucose, [ 28 ] and other internal and external factors. These MNs always exhibit more excellent performance for biomedical application especially in the field of precise treatment and detection.…”

Section: Introductionmentioning

confidence: 99%

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Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

Weng

et al. 2023

Macromolecular Bioscience

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Microneedles (MNs) are a new type of drug delivery method that can be regarded as an alternative to traditional transdermal drug delivery systems. Recently, MNs have attracted widespread attention for their advantages of effectiveness, safety, and painlessness. However, the functionality of traditional MNs is too monotonous and limits their application. To improve the efficiency of disease treatment and diagnosis by combining the advantages of MNs, the concept of intelligent stimulus‐responsive MNs is proposed. Intelligent stimuli‐responsive MNs can exhibit unique biomedical functions according to the internal and external environment changes. This review discusses the classification and principles of intelligent stimuli‐responsive MNs, such as magnet, temperature, light, electricity, reactive oxygen species, pH, glucose, and protein. This review also highlights examples of intelligent stimuli‐responsive MNs for biomedical applications, such as on‐demand drug delivery, tissue repair, bioimaging, detection and monitoring, and photothermal therapy. These intelligent stimuli‐responsive MNs offer the advantages of high biocompatibility, targeted therapy, selective detection, and precision treatment. Finally, the prospects and challenges for the application of intelligent stimuli‐responsive MNs are discussed.

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ROS‐Responsive Microneedle Patch for Acne Vulgaris Treatment (Adv. Therap. 3/2018)

Cited by 7 publications

References 0 publications

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion

Highly Porous Silk Fibroin Scaffold Packed in PEGDA/Sucrose Microneedles for Controllable Transdermal Drug Delivery

Advances in Intelligent Stimuli‐Responsive Microneedle for Biomedical Applications

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