Introduction: Endodontic treatment of necrotic permanent teeth with incomplete rhizogenesis requires professional expertise, especially when the patient is an adult, with a history of trauma. Calcium hydroxide specification has drawbacks. Synthetic apical barriers with a variety of materials were proposed as alternatives to the traditional method of treating necrotic teeth with incomplete rhizogenesis. HP PBS cement mainly contains the biocompatibility and bioactivity properties, which enable it to be used in these cases as a single shutter material in a single session. Objective: The purpose of this study was to observe the rehabilitation and regeneration of periapical tooth tissues with necrotic incomplete rhizogenesis after endodontic obturation using PBS® HP non-conventional biological cement. Case report: This report presents the case of an adult patient with apical lesion, fistula and incomplete rhizogenesis in the tooth 2.2. The initial diagnosis was by periapical radiography. The mechanical chemical preparation of the root canal and filling with PBS® HP cement was performed as a single element. Six months later, the patient underwent re-preservation, which identified the rehabilitation of the tooth and periapical tissues. Conclusion: PBS® HP cement has determined regeneration of periapical tissues and may be indicated as a synthetic barrier in necrotic teeth with incomplete rhizogenesis.