Room temperature synthesis of block copolymer nano-objects with different morphologies <i>via</i> ultrasound initiated RAFT polymerization-induced self-assembly (sono-RAFT-PISA)

Wan, Jing; Fan, Bo; Liu, Yiyi; Hsia, Tina; Qin, K. Peter; Junkers, Thomas; Teo, Boon Mian; Thang, San H.

doi:10.1039/d0py00461h

Cited by 38 publications

(40 citation statements)

References 62 publications

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“…This phenomenon was observed in a previous study as well. 21 Despite the relatively broad Ð, the subsequent characterizations indicate that it did not adversely affect the formation of uniform polymer nanoparticles. The triblock copolymer dispersions were further analyzed by DLS and TEM.…”

Section: Synthesis Of Peg113-b-pdmaema-b-phpma Triblock Copolymer Nanoparticlesmentioning

confidence: 99%

“…S1) was synthesized through Steglich esterification according to a previously published procedure. 21 The PEG113-CDTPA was then chain extended with monomer DMAEMA in 1,4-dioxane (Scheme 2) via RAFT polymerization, 27,28 yielding a diblock copolymer PEG113-b-PDMAEMA-CDTPA. To study the influence of the chain lengths of PDMAEMA on the formation of polymer nanoparticle and polymer-metal nanocomposites, three different batches were synthesized (Table S1).…”

Section: Synthesis Of Peg113-b-pdmaema-b-phpma Triblock Copolymer Nanoparticlesmentioning

confidence: 99%

“…Our previous study has demonstrated a roomtemperature ultrasound-initiated PISA process without the addition of any thermo-/photo-initiators. 21 The sonolysis of H2O and generation of H˙ and ˙OH to initiate RAFT polymerization in PISA provide a "green" alternative compared to the conventional thermo-/photo-process. Furthermore, ultrasound allows the preparation of gold colloids and palladium colloids without the addition of any reducing agents, [22][23][24][25][26] as the H˙ generated during sonolysis can also reduce metal ions to form metal nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

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Sonochemical preparation of polymer–metal nanocomposites with catalytic and plasmonic properties

2021

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Section: Synthesis Of Peg113-b-pdmaema-b-phpma Triblock Copolymer Nanoparticlesmentioning

confidence: 99%

Section: Synthesis Of Peg113-b-pdmaema-b-phpma Triblock Copolymer Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sonochemical preparation of polymer–metal nanocomposites with catalytic and plasmonic properties

2021

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“…To synthesize the stimuli-responsive ABCs, PEG methyl ether (PEG 114 , average M n = 5000 g/mol) was firstly coupled with RAFT agent 4-cyano-4 (((dodecylthio) carbonothioyl)thio) pentanoic acid (CDPA) through Steglich esterification. CDPA is a commercially available RAFT agent that was widely used to control the polymerization of different types of monomers, including styrene, (meth)acrylate and (meth)acrylamide [63][64][65][66]. The long alkyl chain of CDPA allows it to work as the hydrophobic tail in ABC1.…”

Section: Synthesis Of Stimuli-responsive Abcsmentioning

confidence: 99%

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

et al. 2021

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Non-lamellar lyotropic liquid crystalline (LLC) lipid nanoparticles contain internal multidimensional nanostructures such as the inverse bicontinuous cubic and the inverse hexagonal mesophases, which can respond to external stimuli and have the potential of controlling drug release. To date, the internal LLC mesophase responsiveness of these lipid nanoparticles is largely achieved by adding ionizable small molecules to the parent lipid such as monoolein (MO), the mixture of which is then dispersed into nanoparticle suspensions by commercially available poly(ethylene oxide)–poly(propylene oxide) block copolymers. In this study, the Reversible Addition-Fragmentation chain Transfer (RAFT) technique was used to synthesize a series of novel amphiphilic block copolymers (ABCs) containing a hydrophilic poly(ethylene glycol) (PEG) block, a hydrophobic block and one or two responsive blocks, i.e., poly(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate) (PTBA) and/or poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). High throughput small angle X-ray scattering studies demonstrated that the synthesized ABCs could simultaneously stabilize a range of LLC MO nanoparticles (vesicles, cubosomes, hexosomes, inverse micelles) and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. It was found that the novel functional ABCs can substitute for the commercial polymer stabilizer and the ionizable additive in the formation of next generation non-lamellar lipid nanoparticles. These novel formulations have the potential to control drug release in the tumor microenvironment with endogenous H2O2 and acidic pH conditions.

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“…[ 32 ] More importantly, RAFT polymerization is compatible with a wide range of functional monomers and reaction media, and is arguably the most versatile controlled/living radical polymerization. [ 33–40 ] Herein, the dithiocarbamate‐based RAFT agent PPCP with the incorporation of pyrene functional group that allows the strong π – π stacking between synthesized polymers and GO (Scheme 1) was designed and synthesized. In addition, the presence of the pyrrole group in PPCP allows the formation of brush polymer with a conductive PPy backbone, which can further enhance the interactions between polymers and GO (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Bifunctional RAFT Agent Directed Preparation of Polymer/Graphene Oxide Composites

Hsia

Wan

Fan

et al. 2021

Macromol. Rapid Commun.

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Polymer/graphene oxide (GO) composites, which combine the physical properties of GO and the processability of polymers, are of increasing interest in a variety of applications ranging from conductive foams, sensors, to bioelectronics. However, the preparation of these composites through physical blending demands the polymers with functional groups that interact strongly with the GO. Here the design and synthesis of a new bifunctional reversible addition–fragmentation chain transfer (RAFT) agent are demonstrated, which allows the synthesis of polymers with predetermined molecular weights and low dispersibilities (Ð), while having functionalities at both polymer termini that allow strong binding to GO. To access polymers with diverse thermal and mechanical properties, acrylonitrile–styrene–acrylate (ASA) copolymers with different types of acrylates, both short and long side chains, are synthesized under the control of the bifunctional RAFT agent. Furthermore, the strong binding between GO and the synthesized polymers is verified and explored to prepare polymer/GO composites with diverse tensile strengths and conductivity in the range of semiconductors. Overall, this novel RAFT agent is expected to expand the utility of polymer/GO composites by providing well‐defined polymers with tunable properties and strong binding with GO.

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Room temperature synthesis of block copolymer nano-objects with different morphologies via ultrasound initiated RAFT polymerization-induced self-assembly (sono-RAFT-PISA)

Abstract: The first room temperature synthesis of diblock copolymer nano-objects with different morphologies using ultrasound (990 kHz) initiated reversible addition-fragmentation chain transfer PISA (sono-RAFT-PISA) in aqueous system.

Cited by 38 publications

References 62 publications

Sonochemical preparation of polymer–metal nanocomposites with catalytic and plasmonic properties

Sonochemical preparation of polymer–metal nanocomposites with catalytic and plasmonic properties

Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles

Bifunctional RAFT Agent Directed Preparation of Polymer/Graphene Oxide Composites

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