Abstract. The size of electronic devices has been decreasing to nanometer size regime which requires quantum mechanics to understand its operation and optimization. Many features associated with quantum effects are not all desirable from the engineering point of view: the charging of a nano-capacitor runs into Coulomb blockade; the dielectric constants of nanoparticles is much reduced; the binding energy of the shallow dopants in a nanoscale quantum dots becomes many times of kBT resulting in intrinsic behavior regardless of doping density; etc. There are other serious problems preventing the implementation of redundancy and robustness which are so essential to the electronic devices, for example, inadvertent defects cannot be avoided; contacts and input/output have to be sufficiently small resulting in pushing beyond the frontier of lithography. This article aims to discuss some of the fundamental points still requiring better understanding, and what lies ahead in future nanoelectronics.