Room Temperature N-Arylation of 1,2,4-Triazoles under Ligand-Free Condition

Abstract

A simple and efficient method for N-arylation of 1,2,4-triazole at room temperature was described by the use of predominant (111) facet CuO nanoparticles as a catalyst in ligand-free condition. The catalyst was recyclable, and a variety of substrates give N-arylation product in high yield with short period of reaction time. The wide scope of this catalyst led us to investigate transformations involving less-reactive nitrogen nucleophiles, such as imidazole and pyrazoles. We were pleased to find that various derivatives of azoles were effectively coupled with aryl iodide to afford the desired N-arylated product in excellent yield.

Bio-derived CuO nanocatalyst for oxidation of aldehyde: a greener approach

“…In XRD analysis, the planes (020), (021), (110), (002), ( 111), (042), ( 130), ( 131), ( 150), ( 151), ( 113), ( 200), ( 152), ( 221) and (202) indicates the formation of monoclinic crystallite without having any peak due to the possible Cu 2 O and Cu(OH) 2 impurity and well arrange in specic orientation. 27 The signicant 2q values appeared at 18.2, 24.6, 33.3, 34.9, 35.5, 38.6, 42.3 corresponds to (020), ( 021), ( 002), ( 111), ( 042), ( 138) and (131) planes respectively (Fig. 1A).…”

Copper Complex-catalysed C–N Coupling Reaction of Aryl Iodides with Nitrogen-containing Heterocycles

“…[27][28][29][30][31] We gratefully acknowledge Soran University for support of this work. The mixture was vigorously stirred at 120 °C for 14 h under a dry nitrogen atmosphere.…”

“…All the products are known and the spectroscopic data (FT-IR and NMR) and melting points were consistent with those reported in the literature. [27][28][29][30][31] We gratefully acknowledge Soran University for support of this work.…”

Synthesis, Characterization, 3D Modeling, Biological Activities of Some Metal Complexes of Novel Sulpha Drug Schiff Base Ligand and Its Nano Cu Complex

“…Among these methods, the reduction method was the most popular one because of the simplicity of its device and technical process. In the chemical reduction technique, a copper salt was reduced by a reducing agent such as sodium borohydride, hydrazine (N 2 H 4 ), ascorbate or isopropyl alcohol with cetyltrimethylammonium bromide (CTAB) [32][33]. In this work, the nano compounds were prepared by chemical reduction method using isopropyl alcohol with cetyltrimethylammonium bromide (CTAB) as reducing agent.…”