Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

Song, Fuqiang; Jie, Weibo; Zhang, Ting; Li, Wen; Jiang, Yanjiao; Wan, Liu; Liu, Wenjuan; Li, Xiaocheng; Liu, Bin

doi:10.1039/c6ra15267h

Cited by 38 publications

(41 citation statements)

References 58 publications

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“…In some studies, the rGO/HA grafts have been shown to enhance new bone formation to a significant extent in rabbit calvarial detects, without introducing any sign of inflammatory responses . Encouraged by the excellent capability of rGO to enhance the performance of bioceramics‐based scaffolds, rGO have also been used as a filler to improve the functions of polymer‐based, or composites of polymers and bioceramics‐based scaffolds . Selective examples regarding the applications of rGO in BTE are summarized in Table .…”

Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

131

106

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Bone tissue engineering (BTE) has received significant attention due to its enormous potential in treating critical‐sized bone defects and related diseases. Traditional materials such as metals, ceramics, and polymers have been widely applied as BTE scaffolds; however, their clinical applications have been rather limited due to various considerations. Recently, carbon‐based nanomaterials attract significant interests for their applications as BTE scaffolds due to their superior properties, including excellent mechanical strength, large surface area, tunable surface functionalities, high biocompatibility as well as abundant and inexpensive nature. In this article, recent studies and advancements on the use of carbon‐based nanomaterials with different dimensions such as graphene and its derivatives, carbon nanotubes, and carbon dots, for BTE are reviewed. Current challenges of carbon‐based nanomaterials for BTE and future trends in BTE scaffolds development are also highlighted and discussed.

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Section: Carbon‐based Nanomaterials For Bone Tissue Engineeringmentioning

confidence: 99%

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Peng

Zhao

Zhou

et al. 2020

Adv Healthcare Materials

131

106

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“…In a previous study, we successfully fabricated a 3D rGO/PPY scaffold with good osteogenic performance through a simple electrostatic LBL assembly strategy, followed by an electrochemical deposition process using nickel foam as a template. 8 The prepared 3D rGO/PPY scaffold demonstrated good mechanical properties with hardness of 92.27 AE 4.03 MPa and Young's modulus of 185.94 AE 10.76 MPa. 8 Unfortunately, the 3D rGO/PPY scaffold does not have enough biological activity.…”

Section: Preparation and Characterization Of The Cpp-modied 3d Rgo/pmentioning

confidence: 99%

“…8 The prepared 3D rGO/PPY scaffold demonstrated good mechanical properties with hardness of 92.27 AE 4.03 MPa and Young's modulus of 185.94 AE 10.76 MPa. 8 Unfortunately, the 3D rGO/PPY scaffold does not have enough biological activity. Considering the intriguing calcium binding properties of CPP molecules, in the present study, we assembled the CPP molecules on the developed 3D rGO/PPY scaffold and explored the application of the composite scaffold in bone tissue engineering.…”

Section: Preparation and Characterization Of The Cpp-modied 3d Rgo/pmentioning

confidence: 99%

“…With these guidelines in mind, in a few recent studies, several scaffolds have been successfully developed, such as polyurethane, (PU), 5 biphasic calcium phosphate (BCP), 6 polyethylene glycol (PELA), 7 and 3D rGO/PPY. 8 On the whole, these scaffolds can function as alternative 3D matrixes for bone tissue engineering. However, these scaffolds are usually hydrophobic and lack bioactivity, preventing cell adhesion and proliferation.…”

Section: Introductionmentioning

confidence: 99%

“…Based on this facile strategy, we have successfully fabricated the 3D rGO/PPY scaffold, which has promising applications in bone tissue engineering. 8 The adopted polymer molecules can arbitrarily alter the physiochemical properties of the 3D scaffold and endow the surface with positively or negatively charged states, which pave the way for assembling the CPP molecules on 3D rGO/PPY scaffolds and exploring their application in bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhancing the proliferation of MC3T3-E1 cells on casein phosphopeptide-biofunctionalized 3D reduced-graphene oxide/polypyrrole scaffolds

Jie

Song

et al. 2017

RSC Adv.

Self Cite

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In bone tissue engineering, the 3D macro-scaffold plays an indispensable role as a matrix for cell proliferation, differentiation and tissue formation, for which a bioactive surface is required. Previously, we successfully prepared the 3D macro-reduced graphene oxide/polypyrrole (3D rGO/PPY) scaffold; in the present study, by using casein phosphopeptide (CPP) as a bioactive molecule, we have developed a 3D rGO/PPY/CPP composite scaffold through a simple, but low-cost electrostatic self-assembly method and have explored the application of the composite scaffold in bone tissue engineering. The results have indicated that the CPP successfully modified the backbone of the scaffold, and demonstrated that the developed 3D rGO/PPY/CPP scaffold has excellent hydrophilic behavior and water uptake performance, much better than that of 3D rGO/PPY. In the biomimetic mineralization experiment, the CPP-modified matrix, particularly 3D rGO/PPY/CPP20, could promote the rapid formation of hydroxyapatite in simulated body fluid solution on just the 1 st soaking day. On co-culturing with the MC3T3-E1 cells, the 3D rGO/PPY/CPP20 kept the cells at a higher proliferation state of 5.07 times that of the control group, superior to that of the 3D rGO/PPY/CPP10 (3.88 times) and the 3D rGO/PPY group (2.07 times). The excellent osteoblastic performance of the 3D rGO/PPY/CPP20 composite scaffold can be attributed to the good biological properties of CPP, and the unique 3D macro-structure with a high specific surface area. Our findings suggest that the 3D rGO/PPY/CPP20 can be considered as an attractive scaffold for bone healing and regeneration in the future.

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Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications

Ulasevich

Ryzhkov

Andreeva

et al. 2020

Adv Materials Inter

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Targeted delivery and release of biomolecules, e.g., bone morphogenetic protein (BMP‐2), are gaining high interest due to the application for tissue engineering, diagnostics, surface‐enhanced therapy and lab‐on‐a‐chip. Here, a new hybrid temperature‐responsive system consisting of polypyrrole (PPy) layer, mesoporous titania surface (TMS), and BMP‐2 is proposed. The PPy layer has the light‐to‐heat photothermal property. Dynamic behavior of the PPy layer in response to light can regulate release of BMP‐2. The PPy‐based coatings on TMS have shown to be efficient for storage of BMP‐2 and can be tuned to release BMP‐2 under irradiation. Moreover, the possibility of local delivery and generation of a gradual release of BMP‐2 for regulated cell growth is shown. Furthermore, the fabricated surfaces possess excellent biocompatibility and low cytotoxicity for MC3T3‐E1 cells. It is shown that the released BMP‐2 can effectively promote osteogenic differentiation of MC3T3‐E1 cells. Thus, the TMS/PPy–BMP‐2 is suggested to prolong targeted release of the BMP‐2 for more than 25 days which stimulates osteoblasts’ proliferation. The new stimuli‐responsive hybrid system is promising for targeted, localized, sustained drug release and application in bone tissue engineering.

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Room-temperature fabrication of a three-dimensional reduced-graphene oxide/polypyrrole/hydroxyapatite composite scaffold for bone tissue engineering

Abstract: The development of tissue engineering (TE) provides a promising alternative strategy for bone healing and regeneration.

Cited by 38 publications

References 58 publications

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Bone Tissue Engineering via Carbon‐Based Nanomaterials

Enhancing the proliferation of MC3T3-E1 cells on casein phosphopeptide-biofunctionalized 3D reduced-graphene oxide/polypyrrole scaffolds

Light‐to‐Heat Photothermal Dynamic Properties of Polypyrrole‐Based Coating for Regenerative Therapy and Lab‐on‐a‐Chip Applications

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