Romifidine or medetomidine premedication before propofol‐sevoflurane anaesthesia in dogs

Gómez-Villamandos, R.J.; Redondo, J. I.; Martín, E; Domínguez, Juan M.; Granados, Miguel Ángel Núñez; Estepa, J. C.; Ruiz, I.; Aguilera, Eduardo; Santisteban, J. M.

doi:10.1111/j.1365-2885.2005.00688.x

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…,b; England & Hammond ; Gómez‐Villamandos et al. ). We selected a low dose of TZ compared with the manufacturer's recommendations, because at these high doses, hypoxemia has been reported (Tracy et al.…”

Section: Discussionmentioning

confidence: 99%

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Romifidine and low doses of tiletamine‐zolazepam in dogs

Gómez-Villamandos

Martínez

Navarrete

et al. 2013

Veterinary Anaesthesia and Analgesia

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Section: Discussionmentioning

confidence: 99%

“…; Pypendop & Verstegen ; Sinclair ; Gómez‐Villamandos et al. ). Sedation with romifidine in dogs can result in a reduction in f R (England et al.…”

Section: Discussionmentioning

confidence: 99%

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Romifidine and low doses of tiletamine‐zolazepam in dogs

Gómez-Villamandos

Martínez

Navarrete

et al. 2013

Veterinary Anaesthesia and Analgesia

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“…Romifidine is an imino-imidazolidine derivative, selective and a new α2-adrenoceptor agonist drug that is mostly administered systemically to bring about sedation and analgesia in sheep (Celly, McDonell, Young, and Black, 1997;andKastner, 2006), dogs (Gomez-Villamandos, Redondo, Martin, Dominguez, Granados, Estepa, Ruiz, Aguilera, andSantisteban, 2005), horses (Figueiredo, Muir, Smith, and Wolfrom, 2005), and spinally in goats (Kinjavdekar, Aithal, Amarpal, Pawde, Pratap, and Singh, 2006;and Kinjavdekar, et al 2007). Few studies, if any, had been performed to evaluate the effects of the IV injection of medetomidine or romifidine in buffaloes.…”

Section: Introductionmentioning

confidence: 99%

Studies on the Effect of Medetomidine Versus Romifidine in Buffalo Calves

2007

Assiut Veterinary Medical Journal

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detomidine 10 µg/kg intravenously while in group II, the same five calves, after three weeks, were injected i.v. with romifidine 50 µg/kg. The calves were evaluated at baseline and then at 5, 15, 30, 45, 60, 75 and 90 minutes after drug administration for respiratory rate, heart rate, degree of sedation, muscle relaxation, and response to pedal and pinprick reflexes. Weak time, down time and recovery time were recorded in both groups. ECGs were recorded in all animals at baseline, 5, 10, 15, 30, 45 and 60 min post-injection. Blood samples were taken at baseline, 5, 15, 30, 60 and 90 minutes after drug administration for determination of serum glucose, urea, AST, LDH and CPK. Heart rate decreased significantly in both groups. ECG findings in group I revealed increase in the amplitude of R wave and T waves became monophasic and had higher amplitude while in group II there was an atrioventricular (AV) heart block. Moderate sedation, mild muscle relaxation and mild analgesia were recorded in both groups. There was significant increase in serum glucose in both groups, while group II only showed significant increase in serum urea. Serum AST, LDH and CPK increased significantly in both groups compared to baseline values. It could be concluded that medetomidine and romifidine are considered beneficial for safe investigation and clinical examination in buffalo calves but further restraint or conjunction with other local or general anesthetic is needed for surgical approaches. However, medetomidine is considered superior to omifidine because the later induces prolonged cardiopulmonary depression and comparatively higher serum levels of urea and cardiac enzymes.

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