Roller compaction of moist pharmaceutical powders

Wu, Chuan‐Yu; Hung, W-t; Miguélez-Morán, A.M.; Gururajan, Bindhu; Seville, Jonathan

doi:10.1016/j.ijpharm.2010.02.022

Cited by 36 publications

(8 citation statements)

References 28 publications

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“…This metric, thus is negatively correlated with SF p , meaning that as the material is less porous, its SF p is higher [95]. The moisture content (%HR) is on the opposite side of the TS, which conforms the fact that the TS increases as the moisture content decreases [96]. SF is highly correlated with the variable D 10 , D 50 , D 90 .…”

Section: Latent Variable Modeling In Prediction Of Ribbon Propertiesmentioning

confidence: 62%

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Zhang

et al. 2019

Pharmaceutics

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The purpose of this study is to use a material library to investigate the effect of raw material properties on ribbon tensile strength (TS) and solid fraction (SF) in the roll compaction (RC) process. A total of 81 pharmaceutical materials, including 53 excipients and 28 natural product powders (NPPs), were characterized by 22 material descriptors and were compacted under five different hydraulic pressures. The transversal and longitudinal splitting behaviors of the ribbons were summarized. The TS-porosity and TS-pressure relationships were used to explain the roll compaction behavior of powdered materials. Through defining the target ribbon quality (i.e., 0.6 ≤ SF ≤ 0.8 and TS ≥ 1 MPa), the roll compaction behavior classification system (RCBCS) was built and 81 materials were classified into three categories. A total of 24 excipients and five NPPs were classified as Category I materials, which fulfilled the target ribbon quality and had less occurrence of transversal splitting. Moreover, the multivariate relationships between raw material descriptors, the hydraulic pressure and ribbon quality attributes were obtained by PLS regression. Four density-related material descriptors and the cohesion index were identified as critical material attributes (CMAs). The multi-objective design space summarizing the feasible material properties and operational region for the RC process were visualized. The RCBCS presented in this paper enables a formulator to perform the initial risk assessment of any new materials, and the data modeling method helps to predict the impact of formulation ingredients on strength and porosity of compacts.

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Section: Latent Variable Modeling In Prediction Of Ribbon Propertiesmentioning

confidence: 62%

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Zhang

et al. 2019

Pharmaceutics

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“…The internal friction angles and the flowability decrease and the cohesion increases as the moisture content increases, whereas they are not sensitive to moisture contents below 10% (Wu et al . ). The moisture content of the F. deltoidea powders is above 10%; therefore, the flow function of F. deltoidea is decreased due to the increase in consolidation stress.…”

Section: Resultsmentioning

confidence: 97%

Flow Properties of Ficus Deltoidea Extract Powder and the Binders, Acdisol and Avicel

Salleh

Yusof

Anuar

et al. 2014

J Food Process Engineering

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This work aimed to investigate the flowability properties of the basic powders used to make tablets by means of direct compression. The main product in this study is Ficus deltoidea extract powder, while the excipients operated as binder were croscarmellose sodium (NaCMC or Acdisol) and microcrystalline cellulose (MCC or Avicel). Such excipient powders are essentially water insoluble and can also act as a filler, disintegrator and dissolver in tablet form. In order to compare and optimize powders regarding flowability, a Jenike shear tester was used to measure the flow properties of the powder particle, such as the effective angle of internal friction, flow function and the angle of wall friction. The experimental results showed higher flow property values for binders compared with F. deltoidea extract powder. These results provide essential information for the processing and handling of these powders during storage, transportation and also for the next processing step of powder -tabletting.

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“…a Average tablet tensile strength (n=5) and standard deviation at increasing compaction pressures for paracetamol powder blends (black circle) and granules (p1 (white triangle), p2 (grey white square),p3 (grey white triangle) and p4(black square)) based on HPMC-S. b Average tablet tensile strength (n=5) and standard deviation at increasing compaction pressures for paracetamol powder blends (black circle) and granules (p5 (white triangle), p6 (grey white square), p7 (grey white triangle) and p8(black square)) based on HPMC-DC Higher roll speeds resulted in ribbons that crumbled. This is a common seen feature for plastically deforming materials, where the particle bonding is depended on the dwell time at the nip area (34). Further, the ribbon achieved was not continuous and the material stuck to the rolls due to the adhesiveness of the powder blend.…”

Section: Roller Compaction Of Ibuprofen Compositionsmentioning

confidence: 99%

Roller Compaction of Hydrophilic Extended Release Tablets—Combined Effects of Processing Variables and Drug/Matrix Former Particle Size

et al. 2014

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Abstract. The present study shows that roller compaction (RC) can successfully be used as a granulation method to prepare hydroxypropyl methylcellulose (HPMC)-based extended release matrix tablets containing a high drug load, both for materials deforming mainly by fragmentation (paracetamol) as for those having mainly plastic deformation (ibuprofen). The combined effect of RC process variables and composition on the manufacturability of HPMC tablets was investigated. Standard wet granulation grade HPMC was compared with a larger particle size direct compressible HPMC grade. Higher roll pressure was found to result in larger paracetamol granules and narrower granule particle size distributions, especially for formulations containing smaller size HPMC. However, for ibuprofen, no clear effect of roll pressure was observed. High roll pressure also resulted in denser ribbon and less bypass fines during RC. Loss of compactibility was observed for granules compared to powder blends, which was found to be related to differences in granule porosity and morphology. Using the large-sized HPMC grade did in some cases result in lower tensile strength tablets but had the advantage to improve the powder flow into the roller compactor. This work also indicates that when the HPMC level lies near the percolation threshold, significant changes can occur in the drug release rate due to changes in other factors (raw material characteristics and processing).

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Roller compaction of moist pharmaceutical powders

Cited by 36 publications

References 28 publications

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Using a Material Library to Understand the Impacts of Raw Material Properties on Ribbon Quality in Roll Compaction

Flow Properties of Ficus Deltoidea Extract Powder and the Binders, Acdisol and Avicel

Roller Compaction of Hydrophilic Extended Release Tablets—Combined Effects of Processing Variables and Drug/Matrix Former Particle Size

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