Roll-to-Roll Manufacturing of Integrated Immunodetection Sensors

Liedert, Christina; Rannaste, Lauri; Kokkonen, Annukka; Huttunen, Olli‐Heikki; Liedert, Ralph; Hiltunen, Jussi; Hakalahti, Leena

doi:10.1021/acssensors.0c00404

Cited by 26 publications

(22 citation statements)

References 35 publications

(69 reference statements)

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“…Additionally, the easiness to produce lamination of different materials offer further possibilities for foil-based systems. Liedert et.al [197] have described roll-to-roll manufacturing of disposable microfluidic devices. We focus the discussion here on polymerbased foil and use the definition of foils given by Focke et al [198] of a flexible sheet thinner than 500 µm.…”

Section: Film or Sheet Operationsmentioning

confidence: 99%

Fabrication Methods for Microfluidic Devices: An Overview

2021

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Microfluidic devices offer the potential to automate a wide variety of chemical and biological operations that are applicable for diagnostic and therapeutic operations with higher efficiency as well as higher repeatability and reproducibility. Polymer based microfluidic devices offer particular advantages including those of cost and biocompatibility. Here, we describe direct and replication approaches for manufacturing of polymer microfluidic devices. Replications approaches require fabrication of mould or master and we describe different methods of mould manufacture, including mechanical (micro-cutting; ultrasonic machining), energy-assisted methods (electrodischarge machining, micro-electrochemical machining, laser ablation, electron beam machining, focused ion beam (FIB) machining), traditional micro-electromechanical systems (MEMS) processes, as well as mould fabrication approaches for curved surfaces. The approaches for microfluidic device fabrications are described in terms of low volume production (casting, lamination, laser ablation, 3D printing) and high-volume production (hot embossing, injection moulding, and film or sheet operations).

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Section: Film or Sheet Operationsmentioning

confidence: 99%

Fabrication Methods for Microfluidic Devices: An Overview

2021

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“…Polyelectrolyte multilayers films (PEM) deposited by layer‐by‐layer (LbL) assembly, achieved through alternate adsorption of cationic and anionic polymeric species have seen a huge surge in their applications over the last few decades. [ 1–7 ] The flexible experimental advances in tailoring the PEM with wide range of functionalities have made them popular for designing smart PEM configurations. The PEM stacks offer incorporation of wide range of materials, including biomolecules within the PEM matrix.…”

Section: Introductionmentioning

confidence: 99%

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Pahal

Boranna

Prashanth

et al. 2021

Macro Chemistry & Physics

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The matrix properties of polyelectrolyte multilayer thin films (PEM) are critical in making them a viable candidate for various biomedical applications. The location and ability of molecules to diffuse through the PEM architecture determines their encapsulation and release capabilities in a given matrix for various biomedical applications. The main aim of this review article is to provide a complete understanding of molecular transport on the surface as well as across the bulk of the PEM matrix. Different physiochemical strategies to promote or suppress the diffusivity of various molecules inside the PEM are mentioned in brief. A set of guiding principles is uncovered for getting a complete picture of loading and release of molecules across the PEM structure, which can play a key role in designing a desirable PEM assembly and have important implications for designing multicomponent, targeted and controlled drug‐delivery vehicles. Understanding the molecular diffusivity in PEM stack at the nano and micro scales will help to design superior host materials for biomedical engineering applications.

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“…Accordingly, much recent activity has centered on assessing manufacturing technologies that allow for the fabrication of highly integrated systems. To this end, Liedert and co-workers have developed a roll-to-roll process for the large-scale fabrication of highly integrated microfluidic sensors, at rates in excess of 60 devices per hour . Significantly, the fabricated sensors could then be used for the rapid and sensitive detection of C-reactive protein in whole blood.…”

mentioning

confidence: 82%

“…To this end, Liedert and co-workers have developed a roll-to-roll process for the large-scale fabrication of highly integrated microfluidic sensors, at rates in excess of 60 devices per hour. 8 Significantly, the fabricated sensors could then be used for the rapid and sensitive detection of C-reactive protein in whole blood. At the other end of the scale, Gizeli and associates have developed a 3D-printed platform for nucleic acid analysis, integrating DNA amplification and acoustic detection at the point-of-care and using crude biological samples such as whole blood, saliva, or nasal swabs.…”

mentioning

confidence: 99%

Sensors Around the World: Europe, Middle East, and Africa

deMello¹

2021

ACS Sens.

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Roll-to-Roll Manufacturing of Integrated Immunodetection Sensors

Cited by 26 publications

References 35 publications

Fabrication Methods for Microfluidic Devices: An Overview

Fabrication Methods for Microfluidic Devices: An Overview

Simplifying Molecular Transport in Polyelectrolyte Multilayer Thin Films

Sensors Around the World: Europe, Middle East, and Africa

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