Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia

Hao, Jian; Liu, M.-G.; Yu, Yao-Qing; Cao, Fa-Le; Li, Z.; Lu, Zhuo-Min; Chen, J.

doi:10.1016/j.neuroscience.2007.12.038

Cited by 38 publications

(23 citation statements)

References 56 publications

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“…The facial numbness experienced by case 1 may be possibly caused by apamin and melittin. Recently, Chen et al 11 and Hao et al 12 showed that peripheral mitogen-activated protein kinase signal transduction pathways may play some roles in bee venominduced nociception and inflammation. A bee sting injury that is not treated immediately may result in a more severe corneal inflammation condition similar to viral keratitis and require long-term treatment with topical steroids.…”

Section: Discussionmentioning

confidence: 99%

Bee Sting of the Cornea and Conjunctiva: Management and Outcomes

Lin

Wang

Hwang

et al. 2011

Cornea

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Section: Discussionmentioning

confidence: 99%

Bee Sting of the Cornea and Conjunctiva: Management and Outcomes

Lin

Wang

Hwang

et al. 2011

Cornea

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“…Recently, our lab has performed series of behavioral, electrophysiological and biochemical experiments to examine potential roles of the MAPK signaling family in the development and maintenance of BV-induced pathological pain [209][210][211][212][213][214][215][216] .…”

Section: Pain-induced Changes In the Activationmentioning

confidence: 99%

Roles of the hippocampal formation in pain information processing

2009

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Abstract:Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchicallyinterconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation (HF) in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.

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“…More recently, phosphorylated forms of ERK, p38, and JNK in primary afferent neurons have been shown to produce exaggerated pain sensation, suggesting that MAPK pathways can increase pain hypersensitivity via peripheral mechanisms [109-114]. Recent pharmacological studies showed differential roles of peripheral MAPK signal transduction pathways in different types of pain induced by inflammation [115,116]. For example, inhibitors of ERK, p38, and JNK have been shown to effectively alleviate inflammatory and neuropathic pain in different animal models.…”

Section: Mapk and Other Kinasesmentioning

confidence: 99%

Cdk5: An Emerging Kinase in Pain Signaling

2012

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Pain is an important survival mechanism for an organism. It can turn into severe mental and physical disorder however, if the molecular and/or cellular pathways involved in pain signaling are altered. Chronic pain is characterized by an altered pain perception that includes allodynia (a response to a normally non-noxious stimulus) and hyperalgesia (an exaggerated response to a normally noxious stimulus). Past few years of pain research has been mainly focused on precise understanding of the molecular and cellular nociceptive signatures altered during chronic pain, so that more effective pain relievers can be developed. The importance of protein kinases in normal cellular homeostasis and disease pathogenesis has evolved rapidly in the past few decades. The recent advancement defining the role of multiple protein kinases in regulating neuronal plasticity and pain sensitization has gained enough attention of pharmaceutical industry to develop specific and selective kinase inhibitors as analgesics. Cyclin-dependent kinase 5 (Cdk5) is one such emerging kinase in pain biology. We will discuss here the recent advancement and therapeutic potential of Cdk5 in pain signaling.

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Roles of peripheral mitogen-activated protein kinases in melittin-induced nociception and hyperalgesia

Cited by 38 publications

References 56 publications

Bee Sting of the Cornea and Conjunctiva: Management and Outcomes

Bee Sting of the Cornea and Conjunctiva: Management and Outcomes

Roles of the hippocampal formation in pain information processing

Cdk5: An Emerging Kinase in Pain Signaling

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