Roles of the hippocampal formation in pain information processing

Liu, Ming-Gang; Chen, Jun

doi:10.1007/s12264-009-0905-4

Cited by 143 publications

(125 citation statements)

References 255 publications

(417 reference statements)

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“…30 Atypical hippocampal activation and functional connectivity have been demonstrated in prior migraine studies. 31 We theorize that greater pain-induced hippocampal activation in migraineurs is due to strong memory of pain from recurrent migraines.…”

Section: Discussionmentioning

confidence: 93%

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

et al. 2014

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Objective To identify brain regions having aberrant pain-induced activation in migraineurs, thereby gaining insight into particular aspects of pain processing that are atypical in migraineurs. Methods Functional magnetic resonance imaging assessed whole brain responses to painful heat in 24 adult episodic migraineurs who were at least 48 hours pain free and 27 healthy controls. Regions differentially activated in migraineurs compared to controls were identified. Activation intensities in these regions were correlated with headache frequency, number of migraine years, and time to next migraine attack. Results Migraineurs had greater pain-induced activation of lentiform nucleus, fusiform gyrus, subthalamic nucleus, hippocampus, middle cingulate cortex, premotor cortex, somatosensory cortex and dorsolateral prefrontal cortex, and less activation in precentral gyrus and superior temporal gyrus. There were significant correlations between activation strength and headache frequency for middle cingulate (r=0.627, p=.001), right dorsolateral prefrontal cortex (r=.568, p=.004), left fusiform gyrus (r=0.487, p=.016), left precentral gyrus (r=.415, p=.044), and left hippocampus (r=0.404, p=.050) and with number of migraine years for left fusiform gyrus (r=0.425, p=.038). There were no significant correlations between activation strength and time to next migraine attack. Conclusions The majority of regions with enhanced pain-induced activation in headache-free migraineurs participate in cognitive aspects of pain perception such as attending to pain and pain memory. Enhanced cognitive pain processing by migraineurs might reflect cerebral hypersensitivity related to high expectations and hypervigilance for pain.

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Section: Discussionmentioning

confidence: 93%

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

et al. 2014

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“…Pain is conducted by a complex neural network in the central nervous system (Liu & Chen, 2009). Chronic pain not only manifests hyperalgesia, allodynia, and spontaneous pain but also leads to various mood diseases, such as anxiety and depression (Liu & Chen, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Chronic pain not only manifests hyperalgesia, allodynia, and spontaneous pain but also leads to various mood diseases, such as anxiety and depression (Liu & Chen, 2009). Thus, studies concerning pain are no longer restricted to the spinal cord, anterior cingulate, and almond, which have long been accepted as pain centers.…”

Section: Introductionmentioning

confidence: 99%

Hippocampal AMPARs involve the central sensitization of rats with irritable bowel syndrome

Chen

Tang

et al. 2017

Brain and Behavior

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ObjectiveThe roles of hippocampal AMPARs were investigated in irritable bowel syndrome (IBS)‐like rats to clarify the central sensitization mechanisms.Methods IBS model was induced by neonatal maternal separation. The effects of AMPARs on visceral hypersensitivity were examined by the responses of abdominal muscle to colorectal distension after the bilateral intrahippocampal injections of CNQX (an AMPAR inhibitor). The expressions of hippocampal AMPARs (GluR1 and GluR2) were determined by Western blot.ResultsThe IBS‐like rats showed visceral hypersensitivity when compared with controls. Bilateral intrahippocampal injections of CNQX alleviated the visceral pain in IBS‐like rats. The maximal effect appeared at the time point of 30 min, and the duration lasted for 90 min after CNQX application, under 40 and 60 mmHg CRD. The expressions of hippocampal GluR2 significantly increased in IBS‐like rats when compared with controls (p < .05). However, the levels of hippocampal GluR1 had no significant differences in rats. Hippocampal LTP induced by HFS was significantly enhanced when compared with controls (p < .05). The expressions of GluR2 significantly increased in the control and IBS‐like rats after 60 min LTP of recordings (p < .05), but not GluR1.ConclusionNeonatal maternal separation enhances the expression of GluR2 and facilitates the LTP in the hippocampus, which could lead to the formation of visceral hypersensitivity when grown up.

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“…injection linked contextually to the doctor's office) appears to be interpreted in the Hip rather than the Amy. [132][133][134] This is of note given the role that the Hip plays in remembering the location, timing, and context of noxious stimuli and also the fact that the structure is often hypoactive and atrophied in subjects with PTSD 135 and chronic pain, 136 suggesting that the ability to contextualize a painful stimulus may be altered in these individuals. These studies also appear to indicate that nocioceptive input may not be needed to trigger the experience of pain and that other sensory, proprioceptive, or environmental stimuli, whether perceived or not, may be capable of triggering pain responses related to previous history and interpretation of stimuli, even in the absence of actual tissue damage.…”

Section: Unconscious Pairing and Contextual Conditioningmentioning

confidence: 99%

The role of associative learning and fear in the development of chronic pain – a comparison of chronic pain and post-traumatic stress disorder

Sueki

Dunleavy

Puentedura

et al. 2014

Physical Therapy Reviews

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Background: Associative learning is the theory that two stimuli can be paired to produce similar behavioral responses. In this model, a previously innocuous stimulus can become paired with a noxious stimulus to a point that this previously innocuous stimulus can result in the perception of pain. Objectives: This review discusses concepts related to neural activation and structural alterations in the presence of both chronic pain and post-traumatic stress disorder (PTSD). The role of associative learning and protective memory-based behavioral responses in the perception of pain is explored to provide a framework to inform clinical management of individuals with chronic pain and will be linked to the presence of actual or perceived threat or fear. Major Findings: Current research demonstrates that in individuals with chronic pain, cortical and subcortical processing of information shifts from normal nocioceptive processing areas to the medial prefrontal, anterior cingulate, and insular cortices, as well as the hippocampus (Hip) regions, all of which also show dysregulation, signs of gray matter atrophy, and changes in epigenetic coding. Because these regions are involved in memory, emotional processing, learning, and conditioning, it is reasonable to suggest that associative learning may be involved in the processing of both pain and PTSD. Conclusions: Clinically, rehabilitation paradigms that incorporate early intervention, positive expectation, therapeutic neuroscience education, visual imagery, movement retraining, and manual therapy all have the potential to change not only pain behavior but also the neural circuitry, epigenetic coding, and cortical morphology underlying chronic pain.

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Roles of the hippocampal formation in pain information processing

Cited by 143 publications

References 255 publications

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

Enhanced pain-induced activity of pain-processing regions in a case-control study of episodic migraine

Hippocampal AMPARs involve the central sensitization of rats with irritable bowel syndrome

The role of associative learning and fear in the development of chronic pain – a comparison of chronic pain and post-traumatic stress disorder

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