Roles of microRNA in prostate cancer cell metabolism

Kasomva, Khanmi; Sen, Arnab; Paulraj, Michael Gabriel; Sailo, Stephen Lalfakzuala; Raphael, Vandana; Puro, K.; Assumi, S. R.; Ignacimuthu, S.

doi:10.1016/j.biocel.2018.07.003

Cited by 12 publications

(10 citation statements)

References 87 publications

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“…Therefore, we next probed the miRNA-mediated interaction has been reported to have essential roles in cell glycolytic metabolism and provided new avenues for therapeutics of prostate cancer. 28 miR-1, a tumor suppressive miRNA, has been shown to be down-regulated in prostate cancer. 29 Seeing that the miRNA-targeting mechanisms is highly conservative among species and phylogeny, 293T, one of immortal cell lines, has been widely used transfection for luciferase activity.…”

Section: Discussionmentioning

confidence: 99%

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Niu

Mao

et al. 2018

RSC Adv.

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Section: Discussionmentioning

confidence: 99%

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Niu

Mao

et al. 2018

RSC Adv.

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“…Various studies indicated that some miRNAs related with SIRT1, such as miR-204, miE-212/132, miR-449a, miR-221/ 222, and miR-34a, induce cell growth, invasion, and angiogensis in PCa (Karbasforooshan et al, 2018;Kasomva et al, 2018). Through network prediction, we verified that histone deacetylase SIRT1 3′UTR region has miR-138 specific binding sites, and the high expression of miR-138 can significantly inhibit SIRT1 mRNA and protein expression levels of PCa cells.…”

Section: Discussionmentioning

confidence: 99%

Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer

Guo

Jiang

et al. 2020

Front. Pharmacol.

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Astragalus polysaccharides (APS) is a traditional Chinese medicine and have been proved to involve in multiple biological processes, including inflammation, metabolism, and carcinogenics. However, the specific mechanisms by which APS on prostate cancer (PCa) remains largely unknown. In the current study, we found APS greatly inhibited the proliferation and invasion of PCa cells in a dose-dependent and time-dependent manner in vitro and in vivo. In addition, cellular triglyceride and cholesterol levels were also decreased significantly under APS treatment. Microarray data revealed the SIRT1 expression was markably suppressed under APS exposure. Mechanistic studies demonstrated that over-expression of SIRT1 inhibits the expression and nuclear translocation of SREBP1 via activating AMPK phosphorylation to suppress lipid metabolism. Otherwise, knockdown of SIRT1 significantly promotes AMPK/SREBP1 signaling and its associated target genes. Besides, we also found miR-138-5p was greatly inhibited the SIRT1 expression to regulating cell metabolism by targeting its 3′UTR region. To summarize, our findings suggested that APS inhibits tumorigenesis and lipid metabolism through miR-138-5p/SIRT1/SREBP1 pathways in PCa.

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“…The deregulation of the oxidoreductases as well as other enzymes involved in the glucose metabolism pathways is necessary for its reprogramming. This deregulation has already been connected with microRNAs (miRNAs), both in RCC and in PCa [18,42].…”

Section: Mirnas As Glucose Metabolism Regulatorsmentioning

confidence: 96%

The Impact of Oxidoreductases-Related MicroRNAs in Glucose Metabolism of Renal Cell Carcinoma and Prostate Cancer

Morais¹,

Dias²,

Prior³

et al. 2021

Oxidoreductase

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The reprogramming of metabolism is one of cancer hallmarks. Glucose’s metabolism, as one of the main fuels of cancer cells, has been the focus of several research studies in the oncology field. However, because cancer is a heterogeneous disease, the disruptions in glucose metabolism are highly variable depending of the cancer. In fact, Renal Cell Carcinoma (RCC) and Prostate Cancer (PCa), the most lethal and common urological neoplasia, respectively, show different disruptions in the main pathways of glucose catabolism: glycolysis, lactate fermentation and Krebs Cycle. Oxidoreductases are a class of enzymes that catalyze electrons transfer from one molecule to another and are present in these three pathways, posing as an opportunity to better understand these catabolic deregulations. Furthermore, nowadays it is recognized that their expression is modulated by microRNAs (miRNAs), in this book chapter, we selected the known miRNAs that directly target these oxidoreductases and analyzed their deregulation in both cancers. The characterization of these miRNAs opens a new door that could be applied in patients’ stratification and therapy monitorization because of their potential as cancer biomarkers. Additionally, their delivery to cancer cells, using glucose capped NPs could help establish new therapeutic strategies that would improve RCC and PCa management.

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Roles of microRNA in prostate cancer cell metabolism

Cited by 12 publications

References 87 publications

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Retracted Article: Long noncoding RNA PCA3 regulates glycolysis, viability and apoptosis by mediating the miR-1/CDK4 axis in prostate cancer

Astragalus Polysaccharides Inhibits Tumorigenesis and Lipid Metabolism Through miR-138-5p/SIRT1/SREBP1 Pathway in Prostate Cancer

The Impact of Oxidoreductases-Related MicroRNAs in Glucose Metabolism of Renal Cell Carcinoma and Prostate Cancer

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