Roles of integrin in tumor development and the target inhibitors

Li, Zhaohe; Ding, Youxiang; Guo, Qing; Zhao, Li

doi:10.1016/s1875-5364(19)30028-7

Cited by 34 publications

(27 citation statements)

References 79 publications

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“…The present study hypothesized that β-catenin may mediate cytoskeleton remodeling by overexpressing Hugl-1. The results of the present study demonstrated that β-catenin expression decreased in Hugl-1 overexpressing cells, while the expression levels of integrin β1, another important molecule involved in cytoskeleton remodeling and adhesion (40), remained unchanged ( Fig. 2B and C).…”

Section: Effects Of Hugl-1 On Cell Adhesive Activitysupporting

confidence: 58%

Human giant larvae‑1 promotes migration and invasion of malignant glioma cells by regulating N‑cadherin

et al. 2021

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Human giant larvae-1 (Hugl-1) is a human homologue of Drosophila tumor suppressor lethal ( 2 )-giant larvae and has been reported to be involved in the development of human malignancies. Previous studies performed by our group demonstrated that Hugl-1 inhibits glioma cell proliferation in an intracranial model of nude mice. However, the exact molecular mechanisms underlying the participation of Hugl-1 in glioma invasion and migration, and in the depolarizing process remain largely unknown. Utilizing the U251-MG cells with stable expression of Hugl-1, the present study used wound healing, Transwell invasion and western blot assays to explore the role and specific mechanism of Hugl-1 in glioma invasion and migration. The results of the present study demonstrated that overexpression of Hugl-1 decreased cell-cell adhesion and increased cell-cell extracellular matrix adhesion. In addition, overexpression of Hugl-1 promoted pseudopodia formation, glioma cell migration and invasion. The molecular mechanism of action involved the negative regulation of N-cadherin protein levels by Hugl-1. Overexpression or knockdown of N-cadherin partially suppressed or enhanced the effects of Hugl-1 on glioma cell migration and invasion, respectively. Furthermore, Hugl-1 inhibited cell proliferation, while promoting cell migration, which suggests that it may serve a two-sided biological role in cellular processes. Taken together, these results suggest that Hugl-1 promotes the migration and invasion of malignant glioma cells by decreasing N-cadherin expression. Thus, Hugl-1 may be applied in the development of targeted and personalized treatment.

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Section: Effects Of Hugl-1 On Cell Adhesive Activitysupporting

confidence: 58%

Human giant larvae‑1 promotes migration and invasion of malignant glioma cells by regulating N‑cadherin

et al. 2021

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“…Compelling reports have suggested that speci c cellular receptors, such as integrins and EGFR could mediate the pro-survival signaling pathways and SOX2 activation [28]. However, increasing evidence implicated that blockade of upstream integrins receptors by inhibitors was insu cient to suppress the tumor progression induced by those pro-survival signals [29]. More importantly, the expression of integrin αvβ3 was found in abundant tumor cells/tissues, whereas the expression of SOX2 was only found in those cancer stem cells, which accounted for a little proportion in tumor cells [30,31].…”

Section: Discussionmentioning

confidence: 99%

Deletion of TRIB3 Disrupts the Tumor Progression Induced by Integrin αvβ3 in Lung Cancer

Zhou

Meng

et al. 2021

Preprint

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Background: Integrin αvβ3 have been proposed as crucial determinant for tumor sustained progression and a molecular marker for the estimation of tumor angiogenesis.Our study presented that integrin αvβ3 could efficiently promote the lung cancer proliferation and stem-like phenotypes. And this process is in a tribbles homolog 3 (TRIB3) dependent manner. Result: Mechanistically, integrin αvβ3 could mediate the activation of FAK/AKT pro-survival signaling pathway. Meanwhile, activated TRIB3 interacted with AKT to up-regulated FOXO1 and SOX2 expression, resulting in the sustained tumor progression in lung cancer. Our further analysis revealed that TRIB3 was significantly up-regulated in lung tumor tissues and correlated with the poor outcome in clinic, indicating the potential application of TRIB3 in diagnostic and prognostic estimation for patients with lung cancer.Conclusion:Our study showed here for the first time that integrin αvβ3 promote lung cancer development by activating the FAK/AKT/SOX2 in a TRIB3 dependent signaling pathway, and interrupt TRIB3/AKT interaction significantly improved the outcome of chemotherapy in tumor baring mice, representing a promising therapeutic strategy in lung cancer.

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“…Integrins are performing bidirectional signaling through cellular membranes, which results in "messages" exchange between the ECM and cells or between individual cell [37]. Many integrins are highly expressed in carcinomas of the colon, stomach, breast and pancreas, constituting an important receptor subfamily that is instrumental in the progression and metastasis of cancer [38,39].…”

Section: Discussionmentioning

confidence: 99%

Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1

Zhou¹,

Ni²,

Wang³

et al. 2020

J. Cancer

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Integrin αvβ8 expressed on tumor cells executes crucial regulatory functions during cell adhesion in the tumor microenvironment and supports the activation of TGF-β1. This study aimed to investigate the expression of integrin αvβ8 and its clinical significance in colon cancer, in addition to its influence on the invasion and migration of cancer cells. Our results showed that integrin αvβ8 was an indicator of progression and poor prognosis in patients with colon cancer. Moreover, integrin αvβ8 significantly promoted the invasion and migration of colon cancer cells by the activation of TGF-β1 and upregulation of metalloproteinase-9. Furthermore, suppression of integrin αvβ8 was found to inhibit the growth of colon cancer in vivo. Our results indicate that integrin αvβ8 promotes tumor invasiveness and the migration of colon cancer through TGF-β1 activation and is a potential prognostic biomarker. This study may provide clues to further understand the manner in which the tumor microenvironment mediates the development of colon cancer and develop strategies for novel therapeutic targets in the prevention and treatment of colon cancer.

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Roles of integrin in tumor development and the target inhibitors

Cited by 34 publications

References 79 publications

Human giant larvae‑1 promotes migration and invasion of malignant glioma cells by regulating N‑cadherin

Human giant larvae‑1 promotes migration and invasion of malignant glioma cells by regulating N‑cadherin

Deletion of TRIB3 Disrupts the Tumor Progression Induced by Integrin αvβ3 in Lung Cancer

Integrin αvβ8 serves as a Novel Marker of Poor Prognosis in Colon Carcinoma and Regulates Cell Invasiveness through the Activation of TGF-β1

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