Roles of IL-17A and IL-23 in the Pathogenesis of Ulcerative Colitis and Crohn’s Disease

Abdul-Hussein, Sarah S.; Ali, Ekhlass N.; Al-Khalidi, Nawal M.; Zaki, Neihaya H.; Ad’hiah, Ali H.

doi:10.24996/ijs.2021.62.8.5

Cited by 5 publications

(4 citation statements)

References 35 publications

(40 reference statements)

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“…Most recent reports and research indicate that psoriasis is an abnormal proliferation of keratinocytes mediated by T lymphocytes [7]. IL-23 is primarily produced by antigen-presenting cells (APC), and its receptor is expressed by a wide range of innate and adaptive immune cells to enhance their functions [8]. External events like trauma or infection cause host cell-derived nucleotides to form a compound with antimicrobial peptides synthesized by keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

Amar Sabri,

Ibraheem

2024

IHJPAS

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Psoriasis is defined as a series of events that begins in its initial stage with dermatitis and then progresses to more widespread inflammation and increased oxidative stress. The aim of this study was to determine whether psoriasis and the levels of IL-15, IL-23, and TNF-α are related, the ELISA technique was used to detect the levels of inflammation in psoriasis patients and to compare them with healthy individuals. This study included 150 samples, including 90 patients with psoriasis and 60 healthy individuals, and the study was conducted from November 2021 to April 2022. The current study revealed that there was a significant difference in the level of TNF-α in the group of psoriasis patients compared to its level in healthy individuals. Also, there was a significant increase in the level of IL-23 in psoriasis patients compared to its level in the healthy individuals, while there was no significant difference in the level of IL15 between the two groups. However, the statistical study showed a positive and highly significant correlation between IL-15 and IL-23 levels in psoriasis patients, as well as the same relationship between IL-15 and TNF-α levels, in addition to a significant correlation between IL-23 and TNF-α levels in the group of patients. This shows that there is a clear association between these interleukins and psoriasis and its association with the inflammatory status of psoriasis patients, although there was no increase in the level of interleukin-15, the association of interleukin-15 with other inflammatory indicators proves its involvement in psoriasis and an indirect effect on the inflammatory state of psoriasis.

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Section: Introductionmentioning

confidence: 99%

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

Amar Sabri,

Ibraheem

2024

IHJPAS

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“…IL-23 has elevated at the initial phases of periodontitis. IL-23 has a role in autoimmune diseases as an example its role in the etiology and pathogenesis of ulcerative colitis and Crohn's disease (18) . Saliva is a hypotonic solution formed by the salivary glands, gingival crevicular fluid, and oral mucosal exudate (19) .…”

Section: Introductionmentioning

confidence: 99%

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Kamil¹,

Ali²

2023

The Egyptian Journal of Hospital Medicine

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Background: In the term of the prevalence of chronic inflammatory conditions manipulating human beings, periodontal diseases were the predominant. Cytokines are proteins of low molecular weight responsible for the inception of inflammatory response and further stages of it in which they coordinate the extent and the duration of the response. IL-23 is a member of a heterodimeric IL-12 cytokine family, generated from macrophages and dendritic cells after the exposure to bacterial pathogens. Saliva is a hypotonic solution formed by the salivary glands, gingival crevicular fluid, and oral mucosal exudate.Objective: this study aimed to find the association of salivary concentration of IL-23 with periodontal health and disease by examining its' level in individuals with healthy periodontium, with dental biofilm-induced gingivitis and periodontitis (localized and generalized). Patient and method: Saliva were collected from 90 participants with age ranged from 20-60 years. All of them were systemically healthy. 25 cases enrolled under the dental biofilm-induced gingivitis group, 25 cases under the localized periodontitis group and 25 cases under the generalized periodontitis group, with 15 subjects under healthy periodontium (control) group. Detection of IL-23 in saliva was done by Enzyme Linked Immunosorbent Assay (ELISA). Results: Our data revealed that the salivary IL-23 level was significantly (P<0.05) reduced in disease groups in comparison to healthy (control) group with a significant difference between dental biofilm-induced gingivitis and localized periodontitis groups. Conclusion: Salivary IL-23 has a significant and negative relationship with all disease groups as compared to healthy subjects.

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“…It is produced by dendritic cells and macrophages and causes an increase in the release of IL-17. Because of its ability to produce IL-17, IL-23 has a specific role in initiating and maintaining autoimmune inflammation [ 10 ]. Numerous studies revealed that the development of Th17 is the first step in expanding autoimmune activities involving IL-23.…”

Section: Introductionmentioning

confidence: 99%

Cut-off values for IL-21 and IL-23 as biochemical markers for pemphigus vulgaris

Al-Hasnawi,

AL-Drobie

2023

JMedLife

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Pemphigus vulgaris (PV) is a potentially fatal mucocutaneous autoimmune disease characterized by severe skin lesions. Interleukin-21 (IL-21) and IL-23 have been linked to several autoimmune inflammatory diseases that may have a critical role in PV immunopathogenesis, including T-helper 17 (Th17) development. This study aimed to compare the serum levels of IL-21 and IL-23 in patients with PV and healthy controls. This case-control study included 90 participants (45 patients and 45 controls). Serum IL-21 and IL-23 were measured using the Sandwich-ELISA method provided by Sunlong Biotech, China. The findings revealed statistically significant results for IL-21 O.D. and Conc. (p=0.012*) and highly significant results for IL-23 O.D. and Conc. (p=0.000**). Furthermore, cut-off values were established for IL-21 (O.D.=0.071 pg/mL, Conc.=6.468 pg/mL) and IL-23 (O.D.=0.141 pg/mL, Conc.=6.745 pg/mL). These results indicate a potential association between PV and IL-21, IL-23, and the identified cut-off values. The particular roles of cytokines and how they can be utilized to treat PV require more investigation. To our knowledge, this was the first study to detect a cut-off point for IL-21 and IL-23 that may be used as novel and cost-effective biochemical markers for disease diagnosis.

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Roles of IL-17A and IL-23 in the Pathogenesis of Ulcerative Colitis and Crohn’s Disease

Cited by 5 publications

References 35 publications

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

A Study Correlation between Levels IL-15, IL-23 and TNF-α in a Sample of Iraqi Psoriasis Patients

Association between The Cytokine IL-23 in Saliva with Periodontal Health and Disease

Cut-off values for IL-21 and IL-23 as biochemical markers for pemphigus vulgaris

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