Roles of Human Papillomaviruses and p16 in Oral Cancer

Sritippho, Thanun; Chotjumlong, Pareena; Iamaroon, Anak

doi:10.7314/apjcp.2015.16.15.6193

Cited by 49 publications

(35 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…(2015)[28] reported the expression of p16 in 21.6% of the patients with OSCC. They also reported a significant association ( P < 0.05) between HPV DNA and p16 with odds ratio of 20 at 95% CI (1.9–211.8).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Smitha¹,

Mohan

Hemavathy

2017

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Background and Aim:Indian patients with oral squamous cell carcinoma (OSCC) are etiologically associated with the use of tobacco and alcohol; yet, a proportion of tumors that may harbor human papillomavirus (HPV) infections cannot be neglected. The following meta-analysis was conducted to address the association of p16INK4a and HPV DNA with OSCC. In addition, the study also provides the updated prevalence of HPV-induced OSCC.Materials and Methods:Literature survey was performed using databases such as PubMed with the help of the following keywords – “HPV infection,” “oral squamous cell carcinoma,” “p16INK4a,” “HPV DNA,” “E6,” “E7,” “L1,” “L2” and “LCR.” Proportion method was performed to derive the forest plot using MedCalc statistical software version 16.4.3.Results:Among 145 research articles, 33 articles were selected for further analysis, in which 13 articles were related to HPV DNA detection in tissues, 11 articles detected the overexpression of p16INK4a and nine articles reported the detection of both HPV DNA and p16INK4a expression. Meta-analysis revealed significant heterogeneity (P < 0.0001) among the articles. Overall, the study consisted of 3339 patients with OSCC, among which 559 patients were diagnosed with the presence of HPV16 DNA with a random proportion of 20.1% at 95% confidence interval (CI) (13.9–27.1, P < 0.0001). Overexpression of p16INK4a protein was observed in 709 patients with a random proportion of 25.4% at 95% CI (14.3–38.3, P < 0.0001).Conclusion:HPV DNA and expression of p16INK4a was suggested as gold standard for the detection of HPV infection in many cases of cancers. Frequency of HPV infection is significantly higher in patients with OSCC as identified through the detection of HPV DNA and p16INK4a expression. Even though the association of HPV infection has been established in head and neck cancer, this review could further the establishment of molecular level interaction of HPV in patients with oral cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Smitha¹,

Mohan

Hemavathy

2017

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

show abstract

“…Annually, more than 650,000 patients worldwide are diagnosed with HNSCC [1]. Cancer of the oral cavity accounts for 2-3 % of all malignancies [2], is ranked as the fifth most common type of cancer [3], and includes cancers of labial and buccal mucosa, anterior two-thirds of tongue, floor of the mouth, gingiva, alveolus, and hard palate. Oral cancer is considered equivalent to squamous cell carcinoma (SCC), because the latter encompasses more than 90 % of cases [4], and approximately, 300,000 new cases are diagnosed annually worldwide [5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Rodríguez-Santamarta

Rodrigo

García-Pedrero

et al. 2016

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The aim of this study was to analyze the prevalence of high-risk HPV in oral squamous cell carcinoma (OSCC) in a northern Spanish population, as well as to ascertain the prognostic role of p16 expression. The examination samples were collected from paraffin tissue blocks, from 125 patients surgically treated between 1996 and 2007. All cases were histologically evaluated, and the presence of HPV was assessed by p16 and p53immunohistochemistry followed by DNA detection by in situ hybridization (ISH) and polymerase chain reaction (PCR) amplification using the combination of consensus primers MY11/GP6 + . Fourteen cases (11 %) were p16-immunopositive, and p53 was scored positive in 73 cases (58 %). Five cases (4 %) showed a simultaneous p16-positive and p53-negative immunostaining. ISH was negative in all the cases. Among the p16INK4a-immunopositive cases, PCR amplification failed to reveal HPV DNA in any tumor samples. There were no statistically significant differences in any clinical or pathological characteristics of the patients regarding p16 expression. T classification, neck-node metastasis, and clinical stage showed outcome relevance. However, no significant differences in cause-specific survival based on p16INK4a were observed. We did not find any high-risk HPV types in our patients, thus, are unlikely that HPV has an important role in the etiology of OSCC. p16INK4a protein was neither an accurate marker of HPV infection nor a prognosis marker in OSCC.

show abstract

“…Una vez que el virus entra a la célula se forman dos proteínas: e6 y e7. La e6 se une a la ubiquitina celular, unión que resulta en la ubiquitinización de p53 con la subsecuente degradación proteolítica [4,[7][8][9]. Se conocen al menos 200 subtipos de vph, y se dividen en virus de bajo y alto riesgo, tal como se muestra en la tabla 1 [10][11][12].…”

Section: Introductionunclassified

Virus del papiloma humano, sus implicaciones en cavidad bucal; una revisión de la literatura

et al. 2018

View full text Add to dashboard Cite

Introducción: el dar a conocer las principales características clínicas de la afectación de algunos virus del papiloma humano en cavidad bucal, permite al profesional de la salud identificar factores de riesgo y las principales lesiones asociadas con el mismo, con el fin de brindar atención oportuna, evitando de esta manera el pasar por alto este tipo de lesiones.Características: el virus del papiloma humano (VPH) pertenece a la familia de los Papillomaviridae que mide entre 50-55 nm de diámetro, son virus pequeños de ADN no envueltos, epiteliotrópicos cuyo genoma está formado por cadenas dobles de cADN, este virus se puede llegar a encontrar de forma latente en el organismo durante años sin evidenciar cambios histológicos o clínicos, o bien puede formar papilomas benignos o verrugas cuyas lesiones consisten en tejido hiperplásico con engrosamiento de la capa espinosa del epitelio y un aumento de la proliferación capilar.Resultados: al tratarse de un virus exclusivamente epiteliotrópico la vía de entrada ocurre a través de micro-rupturas del epitelio que expone a las células de la superficie basal al virus, lo cual explica la alta frecuencia con la que se presenta en las poblaciones.Conclusiones: el odontólogo de práctica general debe conocer las generalidades de los virus VPH, de tal manera que cuando identifiquen alguna lesión relacionada con algunos de los subtipos, pueda orientar al paciente y ofrecer un tratamiento acertado cuando así se requiera

show abstract

Roles of Human Papillomaviruses and p16 in Oral Cancer

Cited by 49 publications

References 50 publications

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Virus del papiloma humano, sus implicaciones en cavidad bucal; una revisión de la literatura

Contact Info

Product

Resources

About

Roles of Human Papillomaviruses and p16 in Oral Cancer

Cited by 49 publications

References 50 publications

Prevalence of human papillomavirus16 DNA and p16INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Prevalence of human papillomavirus16 DNA and p16INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Prevalence of human papillomavirus in oral squamous cell carcinomas in northern Spain

Virus del papiloma humano, sus implicaciones en cavidad bucal; una revisión de la literatura

Contact Info

Product

Resources

About

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis

Prevalence of human papillomavirus16 DNA and p16^INK4a protein in oral squamous cell carcinoma: A systematic review and meta-analysis