Roles of citric and ascorbic acids in enteric iron absorption in rats

Abstract

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

Studies on Fe complexes produced by yeast. II. Physicochemical properties of an Fe(II)-oligosaccharide complex and their relation to Fe absorption.

“…One of the most important factors affecting the gastrointestinal Fe absorption is the solubility of an Fe compound in the small intestine, a major Fe absorption site,' -3) and many reports4, [8][9][10][11][12] therefrom. This suggests that the variation in Fe absorption among the Fe complexes and salts can be explained by the differences in Fe solubility at the physiological pH.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] The luminal factors are, for example, the quantity, chemical forms, solubility, and interactions with ligands (endogenous and exogenous) of Fe compounds in the lumen of the intestine, and the mucosal factors are mostly related to the mechanism of Fe transport and kinetic parameters of the transport. In other words, the absorbability of Fe from Fe compounds depends on how the physicochemical properties of the Fe compounds are reflected in the above factors.…”

ASCORBIC ACID AND OTHER CHELATING AGENTS IN THE TRACE‐MINERAL NUTRITION OF THE APHID MYZUS PERSICAE ON ARTIFICIAL DIETS

“…Mineral complexes with these natural ligands would enter the gut cells of the insect (as is the case for the rat; Hopping & Ruliffson, 1966) more readily than those of EDTA. Mineral complexes with these natural ligands would enter the gut cells of the insect (as is the case for the rat; Hopping & Ruliffson, 1966) more readily than those of EDTA.…”

“…It is known for vertebrates that iron is more readily absorbed in the ferrous than in the ferric state (Venkatachalam et al, 1956), but this may simply be a matter of greater solubility of iron in the ferrous state (Hopping & Ruliffson, 1966). It is known for vertebrates that iron is more readily absorbed in the ferrous than in the ferric state (Venkatachalam et al, 1956), but this may simply be a matter of greater solubility of iron in the ferrous state (Hopping & Ruliffson, 1966).…”

“…The molecular size of citric acid or ascorbic acid, on the other hand, is considerably smaller than that of EDTA. Mineral complexes with these natural ligands would enter the gut cells of the insect (as is the case for the rat; Hopping & Ruliffson, 1966) more readily than those of EDTA. In so doing they could additionally contribute to the nutrition of the animal.…”