Roles of BDNF, dopamine D3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization

Liang, Jing; Zheng, Xiujun; Chen, Jihuan; Li, Yingying; Xing, Xiaoli; Bai, Yunjing; Li, Yingcong

doi:10.1016/j.euroneuro.2010.12.006

Cited by 36 publications

(29 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Under some circumstances, D3 receptors may be important, however, in the immediate effects of drugs of abuse, as a single cocaine infusion increased D3 receptor expression in the NAcc and BDNF in the frontal cortex, medial prefrontal cortex and ventral tegmental area (Le Foll et al, 2005b). In another study, increases in BDNF and D3 receptor expression were found in the NAcc of rats that received sensitizing doses of morphine in a distinct environment (Liang et al, 2011). Increased of D3 receptor have been reported also following alcohol exposure (Leggio et al, 2014; Vengeliene et al, 2006) and nicotine exposure (Le Foll et al, 2003a; Le Foll et al, 2003b).…”

Section: D3 Receptor Densitiesmentioning

confidence: 99%

Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction

Foll

Ciano

2015

European Neuropsychopharmacology

View full text Add to dashboard Cite

Since the cloning of the D3 receptor in the early 1990s, there has been a great deal of interest in this receptor as a possible therapeutic target for drug addiction. The development of a D3 ligand suitable for use in humans has remained elusive, so the study of the function of the D3 receptor and its possible therapeutic efficacy has largely been restricted to animals. Pre-clinical studies have established that systemic administration of D3 ligands, particularly antagonists and partial agonists, can alter drug-seeking in animals. Despite over a decade of research, few studies have investigated the effects of intra-cerebral infusion of D3 ligands on drug-seeking. In the present review, we summarize these studies, which have largely focused on stimulus-controlled behaviors. Converging evidence from studies of D3 receptor expression, Fos and phMRI is also provided to delineate some of the D3 brain systems involved in drug-seeking and taking. The data so far indicate that different brain systems may be involved in different types of stimulus control as well as drug taking.

show abstract

Section: D3 Receptor Densitiesmentioning

confidence: 99%

Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction

Foll

Ciano

2015

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Locomotor sensitization in a morphine-paired environment has been shown to be accompanied by significant increases of BDNF in the NAc. This sensitization can be prevented by intra-NAc infusion of anti-TrkB immunoglobulin (Liang et al, 2011), suggesting that mesolimbic BDNF-TrkB signaling is necessary for behavioral sensitization to opiates.…”

Section: Vta Bdnf and Opiate Abusementioning

confidence: 99%

Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse

Nikulina¹,

Johnston²,

Wang³

et al. 2014

Neuroscience

View full text Add to dashboard Cite

This review discusses the impact of neurotrophins and other trophic factors, including fibroblast growth factor and glial cell line-derived neurotrophic factor, on mood disorders, weight regulation and drug abuse, with an emphasis on stress- and drug-induced changes in the ventral tegmental area (VTA). Neurotrophins, comprising nerve growth factor, brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4/5 play important roles in neuronal plasticity and the development of different psychopathologies. In the VTA, most research has focused on the role of BDNF, because other neurotrophins are not found there in significant quantities. BDNF originating in the VTA provides trophic support to dopamine neurons. The diverse intracellular signaling pathways activated by BDNF may underlie precise physiological functions specific to the VTA. In general, VTA BDNF expression increases after psychostimulant exposures, and enhanced BDNF level in the VTA facilitates psychostimulant effects. The impact of VTA BDNF on the behavioral effects of psychostimulants relies primarily on its action within the mesocorticolimbic circuit. In the case of opiates, VTA BDNF expression and effects seem to be dependent on whether an animal is drug-naïve or has a history of drug use, only the latter of which is related to dopamine mechanisms. Social defeat stress that is continuous in mice or intermittent in rats increases VTA BDNF expression, and is associated with depressive and social avoidance behaviors. Intermittent social defeat stress induces persistent VTA BDNF expression that triggers psychostimulant cross-sensitization. Understanding the cellular and molecular substrates of neurotrophin effects may lead to novel therapeutic approaches for the prevention and treatment of substance use and mood disorders.

show abstract

“…Moreover, it has been shown that rodents exhibit increased locomotor activity when repeated drug administration is paired with a context (context-dependent behavioral sensitization). This effect is less robust when drug administration is not paired with an environment (Koya et al, 2009; Liang et al, 2011b; Liang et al, 2011a). Previous studies have found that contextual conditioning with either cocaine or amphetamine requires the hippocampus (Meyers et al, 2006; Shen et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Hippocampal GluA1-Containing AMPA Receptors Mediate Context-Dependent Sensitization to Morphine

Xia

Portugal²,

Fakira³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

Glutamatergic systems, including α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are involved in opiate-induced neuronal and behavioral plasticity, although the mechanisms underlying these effects are not fully understood. In the present study, we investigated the effects of repeated morphine administration on AMPAR expression, synaptic plasticity, and context-dependent behavioral sensitization to morphine. We found that morphine treatment produced changes of synaptic AMPAR expression in the hippocampus, a brain area that is critically involved in learning and memory. These changes could be observed one week after the treatment, but only when mice developed context-dependent behavioral sensitization to morphine in which morphine treatment was associated with drug administration environment. Context-dependent behavioral sensitization to morphine was also associated with increased basal synaptic transmission and disrupted hippocampal long-term potentiation (LTP), whereas these effects were less robust when morphine administration was not paired with the drug administration environment. Interestingly, some effects may be related to the prior history of morphine exposure in the drug-associated environment, since alterations of AMPAR expression, basal synaptic transmission, and LTP were observed in mice that received a saline challenge one week after discontinuation of morphine treatment. Furthermore, we demonstrated that phosphorylation of GluA1 AMPAR subunit plays a critical role in the acquisition and expression of context-dependent behavioral sensitization, as this behavior is blocked by a viral vector that disrupts GluA1 phosphorylation. These data provide evidence that glutamatergic signaling in the hippocampus plays an important role in context-dependent sensitization to morphine and supports further investigation of glutamate-based strategies for treating opiate addiction.

show abstract

Roles of BDNF, dopamine D3 receptors, and their interactions in the expression of morphine-induced context-specific locomotor sensitization

Cited by 36 publications

References 43 publications

Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction

Neuronal circuitry underlying the impact of D3 receptor ligands in drug addiction

Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse

Hippocampal GluA1-Containing AMPA Receptors Mediate Context-Dependent Sensitization to Morphine

Contact Info

Product

Resources

About