2014
DOI: 10.1016/j.neuroscience.2014.05.028
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Abstract: This review discusses the impact of neurotrophins and other trophic factors, including fibroblast growth factor and glial cell line-derived neurotrophic factor, on mood disorders, weight regulation and drug abuse, with an emphasis on stress- and drug-induced changes in the ventral tegmental area (VTA). Neurotrophins, comprising nerve growth factor, brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4/5 play important roles in neuronal plasticity and the development of different psychopathologies… Show more

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Cited by 39 publications
(29 citation statements)
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“…This may be due to the different biological effects of the different neurotrophic factors. It has been hypothesized that deficits in specific neurotrophic factors such as BDNF, GDNF and NGF predispose individuals to depression or depression-related neurostructural changes (Karege et al, 2005(Karege et al, , 2002Nikulina et al, 2014;Uchida et al, 2011). On the other hand, VEGF may play a compensatory role in the pathophysiology of MDD, as discussed in the previous paragraph.…”
Section: Discussionmentioning
confidence: 98%
“…This may be due to the different biological effects of the different neurotrophic factors. It has been hypothesized that deficits in specific neurotrophic factors such as BDNF, GDNF and NGF predispose individuals to depression or depression-related neurostructural changes (Karege et al, 2005(Karege et al, , 2002Nikulina et al, 2014;Uchida et al, 2011). On the other hand, VEGF may play a compensatory role in the pathophysiology of MDD, as discussed in the previous paragraph.…”
Section: Discussionmentioning
confidence: 98%
“…These data partially dissociated the influence on anxiety and depression-related behaviors, which may be further supported by the fact that the aVTA overexpression of PLCc increased sucrose preference, while the overexpression in the pVTA blunted it. These findings should also be considered in the context of VTA neurotrophic factors and mood disorders (Nikulina et al, 2014;Walsh and Han, 2014), as PLCc participates to the intracellular signaling cascade activated by these factors.…”
Section: Affect and Painmentioning
confidence: 92%
“…The opposite action of the aVTA and the pVTA manipulations on morphine place conditioning was particularly striking after the PLCc overexpression (Bolanos et al, 2003); furthermore, the PLCc overexpression in the aVTA, but not in the pVTA, also enhanced morphine-induced locomotor sensitization . As neurotrophic factors in the VTA have been related to the effects of drug of abuse (Nikulina et al, 2014), the PLCc data suggest that the action of neurotrophic factors might also depend on the considered anteroposterior level within the VTA.…”
Section: Opioidsmentioning
confidence: 99%
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“…Besides these essential and more established roles for DA neurons of the VTA, there is growing awareness of several other functions in which this area is also involved. Through its connections with structures such as the hippocampus, prefrontal cortex, amygdala, and the hypothalamus, the VTA influences spatial learning [6], social behaviors [7], fear [8], food consumption [9], and even analgesia [10]. This considerable diversity is likely due to the heterogeneity of the VTA, the complexity of which is being constantly updated [3,11].…”
mentioning
confidence: 99%