Roles of Adenosine and Its Receptors in Sleep–Wake Regulation

Huang, Zhi‐Li; Zhang, Ze; Qu, Wei‐Min

doi:10.1016/b978-0-12-801022-8.00014-3

Cited by 123 publications

(121 citation statements)

References 95 publications

Supporting

Mentioning

110

Contrasting

Unclassified

Order By: Relevance

“…Like the above mentioned study, drinking Doogh led to significant changes in reaction time, commission error, omission error, and reaction time 6 Iran J Psychiatry Behav Sci. In Press(In Press):e56000.…”

Section: Discussionmentioning

confidence: 62%

“…On the other hand, the hypothalamus regulates sleep-wake cycle using acetylcholine and gamma amino butyric acid (4). However, these are not the only chemical mediators in this regard, and norepinephrine, serotonin, histamine, orexin, dopamine, and melatonin are some neurotransmitters that regulate and stabilize the sleep-wake cycle (5,6). Additionally, adenosine, affecting the pre-optic area, sets off sleep (6,7).…”

Section: Introductionmentioning

confidence: 99%

“…However, these are not the only chemical mediators in this regard, and norepinephrine, serotonin, histamine, orexin, dopamine, and melatonin are some neurotransmitters that regulate and stabilize the sleep-wake cycle (5,6). Additionally, adenosine, affecting the pre-optic area, sets off sleep (6,7). While mediators associated with immunity, such as interleukin beta 1 and tumor necrotizing factor (TNF), facilitate non-REM sleep in physiological conditions (8).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Effect of Doogh (Yogurt Drink) on Reaction Time and Vigilance- Sleepiness of Healthy Young Adults

Naghan

Setareh

Khoundabi

et al. 2018

Iran J Psychiatry Behav Sci

View full text Add to dashboard Cite

Background: Doogh is a traditional dairy product, which is widely used as a popular drink in the Middle East, in general, and in Iran, in particular. There has been no research study regarding its effects on vigilance and mental-cognitive performance so far; the present study aimed at investigating this effect. Methods: In this repeated measurement study, participants included 17 healthy adults between 20 and 40 years old, with adequate night sleep and without any symptoms of daytime sleepiness that entered the clinical trial one at a time via public invitations. The intervention included drinking 250 cc of doogh or water in the morning or in the afternoon. Therefore, there were 4 interventions for each participant with random sequences, lasting 3 to 5 days. Right before and 1.5 to 2 hours after drinking each of the drinks, the participants were assessed using test of variables of attention (TOVA) and sleepiness test via the visual analogue scale (VAS). The data were analyzed by paired t test and general estimating of equation (GEE) model at the final stage. Objectives: The current study aimed at objectively evaluating the effect of Doogh (Yogurt drink) on attention, reaction time and vigilance-sleepiness of healthy young adults. Results: Ten female and 7 male participants took part in the study. Doogh caused a significant increase in reaction time and commission error and reduced vigilance. These changes occurring after drinking doogh were significant in the afternoons, while they were insignificant in the mornings despite the fact that they lasted longer. There was no change regarding TOVA variables caused by water in any of the case. Although reduced level of vigilance was observed after drinking water, the differences were more significant with regards to doogh and its post intervention comparison with water was meaningful. Conclusions: Doogh caused sleepiness in the afternoon time along with a significant increase in reaction time and commission and omission errors. Regarding the cognitive effects of doogh, the timing and activity type of the drinker should be taken into account. Positive effects of drinking doogh on sleepiness and the risk of accidents caused by drinking it should be studied in other research projects.

show abstract

Section: Discussionmentioning

confidence: 62%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Doogh (Yogurt Drink) on Reaction Time and Vigilance- Sleepiness of Healthy Young Adults

Naghan

Setareh

Khoundabi

et al. 2018

Iran J Psychiatry Behav Sci

View full text Add to dashboard Cite

show abstract

“…The infusion of PGD 2 through a microdialysis probe showed that PGD 2 did not induce sleep in most parts of the brain parenchyma but effectively promoted sleep when it was infused into the subarachnoid space underlying the rostral basal forebrain of rats [9,10] where the DP receptor (DPR) is predominantly localized [11] . PGD 2 promoted sleep and increased the extracellular level of adenosine in wild-type (WT) mice but not in DPR knockout (KO) mice [11] , indicating that PGD 2 -induced sleep is DPR-dependent, and adenosine may be a signaling molecule that mediates the somnogenic effect of PGD 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Prostaglandin (PG) D 2 is the most abundant prostanoid produced in the central nervous system of mammals [1] and one of the most potent sleep-inducing substances [2][3][4][5] . Clinical observations show that excessive endogenous production of PGD 2 is responsible for sleep in humans under certain pathological conditions such as systemic mastocytosis [6] and African sleeping sickness [7] .…”

Section: Introductionmentioning

confidence: 99%

Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice

Zhang¹,

Huang²,

Chen

et al. 2017

Acta Pharmacol Sin

Self Cite

View full text Add to dashboard Cite

Prostaglandin D 2 (PGD 2 ) is one of the most potent endogenous sleep promoting substances. PGD 2 activates the PGD 2 receptor (DPR) and increases the extracellular level of adenosine in wild-type (WT) mice but not DPR knockout (KO) mice, suggesting that PGD 2 -induced sleep is DPR-dependent, and adenosine may be the signaling molecule that mediates the somnogenic effect of PGD 2 . The aim of this study was to determine the involvement of the adenosine A 2A receptor (A 2A R) in PGD 2 -induced sleep. We infused PGD 2 into the lateral ventricle of WT and A 2A R KO mice between 20:00 and 2:00 for 6 h, and electroencephalograms and electromyograms were simultaneously recorded. In WT mice, PGD 2 infusion dose-dependently increased non-rapid eye movement (non-REM, NREM) sleep, which was 139.1%, 145.0% and 202.7% as large as that of vehicle-treated mice at doses of 10, 20 and 50 pmol/min, respectively. PGD 2 infusion at doses of 20 and 50 pmol/min also increased REM sleep during the 6-h PGD 2 infusion and 4-h post-dosing periods in WT mice to 148.9% and 166.7%, respectively. In A 2A R KO mice, however, PGD 2 infusion at 10 pmol/min did not change the sleep profile, whereas higher doses at 20 and 50 pmol/min increased the NREM sleep during the 6-h PGD 2 infusion to 117.5% and 155.6%, respectively, but did not change the sleep in the post-dosing period. Moreover, PGD 2 infusion at 50 pmol/min significantly increased the episode number in both genotypes but only enhanced the episode duration in WT mice. The results demonstrate that PGD 2 -induced sleep in mice is mediated by both adenosine A 2A R-dependent and -independent systems.

show abstract

Feasibility of applying a noninvasive method for sleep monitoring based on mouse behaviors

Wang,

Zhang,

et al. 2023

Brain and Behavior

View full text Add to dashboard Cite

IntroductionCurrently, electroencephalogram (EEG)/electromyogram (EMG) system is widely regarded as the “golden standard” for sleep monitoring. Imperfectly, its invasive monitoring may somehow interfere with the natural state of sleep. Up to now, noninvasive methods for sleep monitoring have developed, which could preserve the undisturbed and naïve sleep state of mice to the greatest extent, but the feasibility of their application under different conditions should be extensive validated.MethodsBased on existing research, we verified the feasibility of a sleep monitoring system based on mouse behaviors under different conditions. The experimental mice were exposed to various stresses and placed into a combined device comprising noninvasive sleep monitoring equipment and an EEG/EMG system, and the sleep status was recorded under different physiological, pharmacological, and pathophysiological conditions. The consistency of the parameters obtained from the different systems was calculated using the Bland–Altman statistical method.ResultsThe results demonstrated that the physiological sleep times determined by noninvasive sleep monitoring system were highly consistent with those obtained from the EEG/EMG system, and the coefficients were 94.4% and 95.1% in C57BL/6J and CD‐1 mice, respectively. The noninvasive sleep monitoring system exhibited high sensitivity under the sleep‐promoting effect of diazepam and caffeine‐induced wakefulness, which was indicated by its ability to detect the effect of dosage on sleep times, and accurate determination of the sleep/wakeful status of mice under different pathophysiological conditions. After combining the data obtained from all the mice, the coefficient between the sleep times detected by behavior‐based sleep monitoring system and those obtained from the EEG/EMG equipment was determined to .94.ConclusionThe results suggested that behavior‐based sleep monitoring system could accurately evaluate the sleep/wakeful states of mice under different conditions.

show abstract

Roles of Adenosine and Its Receptors in Sleep–Wake Regulation

Cited by 123 publications

References 95 publications

The Effect of Doogh (Yogurt Drink) on Reaction Time and Vigilance- Sleepiness of Healthy Young Adults

The Effect of Doogh (Yogurt Drink) on Reaction Time and Vigilance- Sleepiness of Healthy Young Adults

Adenosine A2A receptor deficiency attenuates the somnogenic effect of prostaglandin D2 in mice

Feasibility of applying a noninvasive method for sleep monitoring based on mouse behaviors

Contact Info

Product

Resources

About