Role ofHelicobacter pylori in cirrhotic patients with dyspepsia: A13C-urea breath test study

Abstract

The role of Helicobacter pylori in dyspeptic, cirrhotic patients remains unclear. This prospective outpatient study, conducted to assess the relationship of gastroduodenal disease and H. pylori as determined by the (13C) urea breath test, enrolled 109 consecutive cirrhotic patients with dyspepsia. All patients underwent upper-gastrointestinal endoscopy, which revealed respective prevalences of peptic ulcer, gastric ulcer, and duodenal ulcer of 41.3%, 23.9%, and 22.9%; H. pylori infection was found in 52.3%. The rate of peptic ulcer disease in the H. pylori-positive (45.6%) and -negative (36.5%) groups was not significantly different; neither was the prevalence of H. pylori in patients with or without portal hypertensive gastropathy and with or without esophageal varices. The relationship between peptic ulcer disease and H. pylori in dyspeptic patients with cirrhosis appears to be weak. Likewise, no significant relationship was evident between H. pylori and portal hypertensive gastropathy or esophageal varices. This organism may not be a major pathogenetic factor in gastroduodenal diseases in dyspeptic patients with cirrhosis.

Consequences of Living-Donor Liver Transplantation for Upper Gastrointestinal Lesions: High Incidence of Reflux Esophagitis

“…The reported incidence of H. pylori infection in cirrhotic cases ranges from 40% to 52% [22,23]. Recent studies have shown that H. pylori infection prevents reflux esophagitis by decreasing gastric acid secretion [24,25].…”

Avoiding Pitfalls: What an Endoscopist Should Know in Liver Transplantation—Part 1

“…We believe all patients with peptic ulcer disease should receive anti-H. pylori therapy irrespective of the result of the tests, as the negative biopsy or the breath test may represent false negatives due to the dilutional effect of PHG. A recent report has indicated a 50% prevalence of H. pylori among patients undergoing liver transplantation [156]. Interestingly, the prevalence dropped to 5% after transplant, despite the fact that the gastroduodenal ulcer prevalence remained the same [157].…”

Helicobacter pylori and hepatocellular carcinoma: Correlated or uncorrelated?

“…In addition, many researchers have reported that H. pylori is detected in liver tissue resected from patients with cirrhosis. The prevalence of H. pylori infection in cirrhosis is 45.5–89% and is significantly higher than in non‐cirrhosis 18–27 . Recently, H. pylori was identified in liver tissue resected from patients with HCC 8–13 .…”

“…The prevalence of H. pylori infection in cirrhosis is 45.5-89% and is significantly higher than in noncirrhosis. [18][19][20][21][22][23][24][25][26][27] Recently, H. pylori was identified in liver tissue resected from patients with HCC. [8][9][10][11][12][13] It is important to determine whether H. pylori infection could lead to inflammation that forces hepatitis to progress to cirrhosis and finally to HCC.…”