<i>Helicobacter pylori</i> and hepatocellular carcinoma: Correlated or uncorrelated?

Wu, Xiaoqing; Chen, Dan

doi:10.1111/j.1440-1746.2006.04245.x

Cited by 18 publications

(14 citation statements)

References 39 publications

(71 reference statements)

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“…Malignant transformation of hepatocytes may occur in the context of chronic inflammation and regeneration. Therefore, do MSC play a possible role in HCC induced by chronic injury? 87 …”

Section: Bone Marrow Cells and Hepatocellular Carcinomamentioning

confidence: 99%

Origin of hepatocellular carcinoma: Role of stem cells

Chen

2006

J of Gastro and Hepatol

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The question of whether hepatocellular carcinoma (HCC) arises from the differentiation block of stem cells or dedifferentiation of mature cells remains controversial. Recently, researchers suggested that HCC may originate from the transdifferentiation of bone marrow cells. Interestingly, there are four levels of cells in the hepatic stem cell lineage: bone marrow cells, hepato-pancreas stem cells, oval cells and hepatocytes. Hematopoietic stem cells and the liver are known to have a close relationship in early development. Bone marrow stem cells could differentiate into oval cells, which could differentiate into hepatocytes and duct cells. The development of pancreatic and liver buds in embryogenesis suggests the existence of a common progenitor cell to both the pancreas and liver. Cellular events during hepatocarcinogenesis illustrate that HCC may arise from cells at various stages of differentiation in the hepatic stem cell lineage.

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“…Malignant transformation of hepatocytes may occur in the context of chronic inflammation and regeneration. Therefore, do MSC play a possible role in HCC induced by chronic injury? 87 …”

Section: Bone Marrow Cells and Hepatocellular Carcinomamentioning

confidence: 99%

Origin of hepatocellular carcinoma: Role of stem cells

Chen

2006

J of Gastro and Hepatol

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“…The most thrilling hypothesis is that these bacteria might play a role in the development of hepatocellular carcinoma [32]. The most thrilling hypothesis is that these bacteria might play a role in the development of hepatocellular carcinoma [32].…”

Section: Helicobacter and Extra-gastric Malignanciesmentioning

confidence: 99%

Helicobacter and Digestive Malignancies

Starzyńska

Malfertheiner

2006

Helicobacter

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Important new data were published during the past year on the relationship of Helicobacter infection and gastric neoplasias. In the pathogenesis of gastric cancer, a thrilling new hypothesis was put forward based on animal experiments. Helicobacter infection induces gastric mucosal damage and bone marrow-derived cells (mobilized into peripheral blood and attracted to the inflamed mucosa) replace the areas of damaged gastric tissue and turn into neoplastic proliferation. Several studies focused on mechanisms related to the development of gastric malignancy in infected individuals with particular attention to inflammatory cytokine gene polymorphisms. Some new evidence is also reported to suggest that Helicobacter infection increases the risk of neoplasias outside the stomach in the liver and colon.

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“…Recently, a new aspect of H. pylori-associated carcinogenesis was being discussed, the role of H. pylori in hepatocarcinogenesis [4]. Several reports indicated an increased prevalence of H. pylori in HCC tissue samples and livers infected with hepatitis viruses [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] or in patients with primary biliary cirrhosis and primary sclerosing cholangitis [25,26]. Other studies, however, also show controversial results [27].…”

Section: Introductionmentioning

confidence: 99%