Role of Zonulin level as new metabolic biomarker in diabetes mellitus patients and associated complications

Khalil, M; Ali, Hanaa Addai; Al-Hilo, Muntadher Abdulabbas Hasan

doi:10.1063/5.0066876

Cited by 2 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[19] The benchmarks that were focused on in the current research were made through the ELISA technique, namely, zonislin, glutathione and TAC, while glucose, creatinine and urea were measured by spectrophotometry. [20] Statistical analysis: The data collated after biochemical analysis were subjected to statistical calculation using statistical software (Megastat). The mean, standard deviation of mean, F-distribution test were obtained.…”

Section: Methodsmentioning

confidence: 99%

Estimation the level of zonulin, antioxidant factors and some biochemical parameters in renal failure patients

Shaker¹,

Ali²,

Audah³

2022

ijhs

View full text Add to dashboard Cite

The kidneys are important organs similar in shape to beans located on both sides of the spine and their function is to filter water and toxic substances from the blood. The kidneys, like other members of the human body, are exposed to failure due to many factors that ultimately lead to kidney damage. About five millimeters of one hundred samples from dialysis patients were kept in test tubes designated for this purpose, where the samples were stored at appropriate temperature until the required number was completed, the same measures were also taken on the healthy group, which numbered fifty samples, and their ages were approximately equal to the ages of the dialysis patients. As for the results of the current research, it was proved that there was a significant increase in the levels of zonulin and the capacity of total antioxidants, urea, creatinine and glucose in dialysis patients compared to the control group. As for glutathione, there is no significant change.

show abstract

Section: Methodsmentioning

confidence: 99%

Estimation the level of zonulin, antioxidant factors and some biochemical parameters in renal failure patients

Shaker¹,

Ali²,

Audah³

2022

ijhs

View full text Add to dashboard Cite

show abstract

“…In a study conducted on CMR pathways with circulating metabolites and food groups, TMAO was found to potentially interact metabolically (p < 0.05) with host traits associated with CMR (1.55fold) and could be modulated by plant-based nutrition [16 Similarly, it has been reported that there is an increase in serum zonulin levels, which can modulate intestinal permeability, in the presence of increased waist circumference, insulin resistance, dyslipidemia, inflammation-related coronary heart disease, and T2DM [5,40]. In a study examining serum parameters for complications of diabetes in individuals with diabetes (n = 90), it was determined that serum zonulin levels showed a positive correlation with total cholesterol, LDL cholesterol, triglyceride, and HOMA-IR levels (p < 0.001) [41]. It has been reported that serum intestinal fatty acid binding protein (I-FABP/FABP2), which is an intracellular protein expressed in intestinal epithelial cells and functions to bind and transport fatty acids, causes atherosclerotic plaque formation in macrophages by affecting lipid and inflammatory responses.…”

Section: Nutrition-related Cardiometabolic Risk Factorsmentioning

confidence: 99%

Dietary Modulations in Preventing Cardiometabolic Risk in Individuals with Type 2 Diabetes

Dal,

Bilici

2024

Curr Nutr Rep

View full text Add to dashboard Cite

Purpose of Review Type 2 diabetes mellitus (T2DM) is a complex health issue include obesity, high cholesterol, high blood pressure, and chronic inflammation that increase the risk of cardiovascular diseases (CVDs). CVDs are of great concern in the disease progression and prognosis of T2DM. This review is a comprehensive examination of the literature on the relationship between T2DM and cardiovascular risk, nutrition-related cardiometabolic risk (CMR) factors, and impact of dietary modulations on CMR. Recent Findings In recent years the researches has been focus on the importance of a comprehensive treatment approach like dietary modulations to address multiple cardiovascular risk reductions, including hypertension and dyslipidemia. Modulation of dietary patterns are the most promising interventions to prevent CMR factors and T2DM via affecting the body weight, glucose control, and microbial diversity of individuals. Current evidence suggests that high-quality dietary patterns such as the Dietary Approaches to Stop Hypertension (DASH) eating plan and the Mediterranean diet is important in the metabolic control processes of T2DM with anti-inflammatory and antioxidant compounds, glucagon-like peptide agonist compounds, and intestinal microbiota changes. Summary Nutrition plays a critical role in preventing and improving CVD outcomes in patients with T2DM. Dietary modulations should be planned considering individual differences in responses to dietary composition and nutritional changes, personal preferences, eating behaviors and gut microbiota differences.

show abstract

Role of Zonulin level as new metabolic biomarker in diabetes mellitus patients and associated complications

Cited by 2 publications

References 29 publications

Estimation the level of zonulin, antioxidant factors and some biochemical parameters in renal failure patients

Estimation the level of zonulin, antioxidant factors and some biochemical parameters in renal failure patients

Dietary Modulations in Preventing Cardiometabolic Risk in Individuals with Type 2 Diabetes

Contact Info

Product

Resources

About