Role of Wound Dressings in the Management of Chronic and Acute Diabetic Wounds

Robin, Augustine

doi:10.1201/b16415-12

Cited by 2 publications

References 4 publications

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Polymer in hemostasis and follow‐up wound healing

Sasmal

Ganguly

2023

J of Applied Polymer Sci

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Polymers offer unique functional properties that lead to some novel applications every other day. Bioactive polymers with high degree of biodegradability, nonimmunogenicity, and biocompatibility are considered for applications in wound healing. The most basic form of wound protection is by gauge dressing that isolates the wound from contaminants. Natural polymers for example, cellulose, alginate, chitosan, starch, dextran, gelatin, hyaluronic acid, glycan, collagen, and synthetic polymers including polymethyl methacrylate (PMMA), polyvinyl alcohol (PVA), polyethylene glycol (PEG), polyvinyl pyrrolidone (PVP) are candidates for these applications. Biopolymers, when applied as wound dressing promote tissue healing and repair by (i) regulating the moist environment, and (ii) providing the needed growth factors, while offering anti-inflammatory, immune-modulatory, and cell proliferative properties. It induces hemostasis via direct interaction with erythrocytes and platelets. These polymers in cross linked state offer a scaffold for cell proliferation, differentiation, and cell migration. Further, these polymeric materials can be utilized to form permeable envelopes around the hemostatic and wound healing agents to leverage a favorable release kinetics. The fabrication strategies and their reported efficacy are reviewed in this article.

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Polymer in hemostasis and follow‐up wound healing

Sasmal

Ganguly

2023

J of Applied Polymer Sci

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Overriding defective FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in diabetic wound

Roy

Zayas

Wood

et al. 2021

Preprint

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Infection is a major co-morbidity that contributes to impaired healing in diabetic wounds. Although impairments in diabetic neutrophils have been blamed for this co-morbidity, what causes these impairments and whether they can be overcome, remain largely unclear. Diabetic neutrophils, extracted from diabetic individuals, exhibit chemotaxis impairment but this peculiar functional impairment has been largely ignored because it appears to contradict the clinical findings which blame excessive neutrophil influx (neutrophilia) as a major impediment to healing in chronic diabetic ulcers. Here, we report that exposure to glucose in diabetic range results in impaired chemotaxis signaling through the FPR1 chemokine receptor in neutrophils, culminating in reduced chemotaxis and delayed neutrophil trafficking in wound in diabetic animals, and rendering diabetic wound vulnerable to infection. We further show that at least some auxiliary chemokine receptors remain functional under diabetic conditions and their engagement by the pro-inflammatory cytokine CCL3, overrides the requirement for FPR1 signaling and substantially improves infection control by jumpstarting the neutrophil response toward infection, and stimulates healing in diabetic wound. We posit that CCL3 may have real therapeutic potential for the treatment of diabetic foot ulcers if it is applied topically after the surgical debridement process which is intended to reset chronic ulcers into acute fresh wounds.

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Role of Wound Dressings in the Management of Chronic and Acute Diabetic Wounds

Cited by 2 publications

References 4 publications

Polymer in hemostasis and follow‐up wound healing

Polymer in hemostasis and follow‐up wound healing

Overriding defective FPR chemotaxis signaling in diabetic neutrophil stimulates infection control in diabetic wound

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