Role of Von Willebrand Factor in Type 2 Diabetes Mellitus Patients

Umadevi, B; Roopakala, M S; R, Wilma Delphine Silvia C; M, Prasanna Kumar K

doi:10.14260/jemds/2016/1372

Cited by 5 publications

(3 citation statements)

References 25 publications

(22 reference statements)

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“…However, under pathologic conditions, vWF plasma level may be used as a biomarker of endothelial damage and dysfunction, since it is secreted almost only by D r a f t endothelial cells (Frankel et al 2008;Meigs 2010). Previous studies demonstrated increased vWF level in type 2 diabetic patients or in insulin resistance (Frankel et al 2008;Umadevi et al 2016), as well as associated increased risk of cardiovascular diseases with higher levels of vWF in these populations (Frankel et al 2008).…”

Section: Discussionmentioning

confidence: 94%

“…It is known that endothelial dysfunction occures in patients with DM and that it plays important role in the development of atherosclerosis (Umadevi et al 2016). In endothelium damage and dysfunction an increase in the plasma levels of endothelial markers, such as von Willebrand factor (vWF) occurs (Umadevi et al 2016). One of the long-term complications of DM and vasculopathy is diabetic nephropathy (Pop-Busui et al 2010) and hepatopathy (Reid 2006).…”

Section: Introductionmentioning

confidence: 99%

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The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

Mutavdzin

Gopčević

Stanković³

et al. 2019

Can. J. Physiol. Pharmacol.

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Diabetes mellitus (DM) is a metabolic disorder that causes severe complications. Thus, the aims of this study were to investigate the influence of DM and folic acid treatment on liver and renal biomarkers, and heart remodeling through evaluation of cardiac matrix metalloproteinase (MMP) activity. There were 4 groups: control (physiological saline 1 mL/kg, i.p., 28 days), DM (streptozotocin [STZ] 100 mg/kg in physiological saline, i.p., 1 day), folic acid (FA; 5 mg/kg, i.p., 28 days), and DM+FA (STZ 100 mg/kg, i.p., 1 day and folic acid 5 mg/kg, i.p., 28 days). Our results demonstrated increased aminotransferase and alkaline phosphatase activity, urea and creatinine concentration, and decreased albumin and fibrinogen concentration in the DM group. MMP-2 relative activity was elevated in the DM and FA groups; MMP-9 was decreased in the DM and increased in the FA group. The folic acid treatment of diabetic rats did not change aminotransferase activity; it alleviated the increase in alkaline phosphatase and the decrease in albumin and fibrinogen concentration, and reduced MMP-2 activity; however, it increased urea and creatinine concentration. In conclusion, folic acid treatment of diabetic rats has cardio- and hepato-protective effects. However, its dosing should be carefully considered because of possible renal damage.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

Mutavdzin

Gopčević

Stanković³

et al. 2019

Can. J. Physiol. Pharmacol.

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“…Legese et al evaluated the risk of type 2 DM in 424 patients and reported an increased risk in the B blood group and a lower risk in the O blood group; however, the Rh blood group and type 2 DM were not significantly related (5). Increased factor VIII-VWF complex, intercellular adhesion molecule-1(ICAM-1), and tumor necrosis factor-2 (TNF-2) levels in those with B blood group have been associated with a higher risk of DM development in these patients (6,7). Aggarwal et al also found a reduced risk of DM in the O blood group.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between ABO and Rh Blood Groups and Microvascular Complications of Diabetes in Patients with Type 2 Diabetes Mellitus

Fakı,

İnce,

Tam

et al. 2024

Turk J Diab Obes

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Aim: This study aimed to investigate the possible relationships between ABO and Rh blood groups and microvascular complications of diabetes in type 2 diabetes mellitus (DM) patients. Material and Methods: This study included Type 2 DM patients who were hospitalized and followed in our clinic between February 2019 and April 2022. The patients’ data files were retrospectively reviewed in order to record demographic characteristics, antidiabetic medications, comorbid diseases, fasting plasma glucose, HbA1c values, ABO/Rh blood groups, and microvascular complication status (nephropathy, retinopathy, and neuropathy). Results: A total of 348 patients were included in the study. In the sample group, male patients constituted 40.9% (142) and female patients 59.1% (206) of the sample, and the mean age was 59.3±12.8 years. Diabetic nephropathy, retinopathy, and neuropathy rates were 31.3%, 41.0%, and 52.0%, respectively. The blood group was A in 151 (43.4%), B in 51 (14.6%), 0 in 127 (36.5%), and AB in 19 (5.5%) patients. Patients with different blood types did not show any significant differences in the microvascular complications of diabetes. The frequency of nephropathy and retinopathy were lower in Rh-negative patients than in Rh-positive patients (p=0.044 and p=0.041, respectively). Conclusion: ABO blood groups are not correlated with the microvascular complications of diabetes in patients with type 2 DM. However, Rh positivity may pose certain risks for nephropathy and retinopathy.

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Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia

Legese

Abebe

Fasil

2020

International Journal of Chronic Diseases

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Background. ABO and Rh blood group antigens are thought to be among genetic determinants of type 2 diabetes mellitus. Identification of blood group phenotypes are more associated with type 2 diabetes mellitus. It will be helpful for individuals who are susceptible blood groups to take care of themselves by avoiding other predisposing factors and taking preventive measures. Methods. Hospital-based comparative cross-sectional study was carried out from February to April 2019 at Felege Hiwot Comprehensive Referral Hospital. Sociodemographic and clinical data were collected with a semistructured pretested questionnaire. ABO and Rh Blood group were determined by slide and test tube methods. Biochemical parameters were determined with Mindray BS-200E fully automated clinical chemistry analyzer. Data were analyzed by IBM SPSS version 20 statistical software. Chi-square test and logistic regression analysis were employed for data analysis. A P value of < 0.05 was considered statistically significant. Results. From a total of 424 participants included for this study, blood group O was found higher in frequency with 74 (34.9%) and 97 (45.75%) for cases and healthy controls, respectively. ABO blood groups showed significant association with T2DM, a chi-square value of 12.163 and P value of 0.007. However, the Rh blood group was not associated with T2DM. Binary logistic regression analysis revealed that blood group B had a higher risk (OR: 2.12, 95% CI: 1.33-3.32) and blood group O had decreased risk (OR: 0.636, 95% CI: 0.43-0.94) of T2DM as compared to other blood groups. Conclusion. ABO blood group antigens showed significant association with type 2 diabetes mellitus. Blood group B was associated with an increased risk and O blood group with decreased risk of type 2 diabetes mellitus.

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Role of Von Willebrand Factor in Type 2 Diabetes Mellitus Patients

Cited by 5 publications

References 25 publications

The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

The effect of folic acid administration on cardiac tissue matrix metalloproteinase activity and hepatorenal biomarkers in diabetic rats

The Relationship Between ABO and Rh Blood Groups and Microvascular Complications of Diabetes in Patients with Type 2 Diabetes Mellitus

Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia

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