Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia

Legese, Biruk; Abebe, Molla; Fasil, Alebachew

doi:10.1155/2020/2535843

Cited by 12 publications

(16 citation statements)

References 32 publications

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“…No associations were found of the blood groups A and AB with T2DM (OR = 1.04, 95% CI: 0.97–1.12 and OR = 1.03, 95% CI: 0.92–1.16, respectively) in the present study, consistent with the findings of previous studies performed in western Algeria, 36 India, 62 and Bangladesh, 15 which also showed no associations between the ABO blood groups and T2DM. In contrast, previous studies have shown that individuals with blood group A are more likely to develop T2DM 38,40 and to have higher insulin and random blood glucose concentrations.…”

Section: Discussionsupporting

confidence: 91%

“…1 In addition, ABO blood group-related susceptibility to various viral infections, including with hepatitis B, influenza viruses, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been shown in several studies. 45,46 However, only some of the previous studies have shown a link between T2DM and ABO blood group: some have shown no link, 15,20,47,48 whereas others have shown a positive association. 14,33 Therefore, in the present study, we explored the relationships of the ABO and Rh blood groups with T2DM by means of a systematic review and meta-analysis.…”

Section: Discussionmentioning

confidence: 97%

“…In addition, Rh blood group negativity and positivity have been shown to be protective or risk factors for T2DM in different studies. [13][14][15] Therefore, we aimed to perform a meta-analysis of the results of previous studies to improve knowledge regarding the associations of ABO and Rh blood groups with T2DM.…”

Section: Introductionmentioning

confidence: 99%

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Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

et al. 2022

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Objectives The susceptibility to type 2 diabetes mellitus (T2DM) has been linked to blood type. We aimed to characterize the relationships of the ABO and Rhesus blood groups with T2DM. Methods Literature searches were performed using the Medline, PubMed, Scopus, Cochrane, EMBASE, and Google Scholar databases to identify studies published up to 31 March 2022. The PRISMA guidelines were used for reporting. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were obtained using fixed-effects models. Results Twenty-six studies of 6870 patients with T2DM and 11,879 controls were identified. Compared with the other ABO groups, people with blood type B were at higher risk of T2DM (OR: 1.30, 95% CI: 1.20–1.41), while group O was associated with a lower risk (OR: 0.92, 95% CI: 0.86–0.98). There were no significant associations of T2DM with blood types A or AB, or Rh factor. Conclusion Individuals with blood type B are at higher risk of developing T2DM. Therefore, they should be screened for T2DM on a frequent basis and be made aware of the importance of maintaining a balanced diet and regular exercise for the prevention of obesity and T2DM. PROSPERO registration number CRD42022353945.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 97%

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Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

et al. 2022

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“…In contrast to our present results, Nigerian people with O- or A+ blood groups appeared to be at a greater risk of developing DM in the ( 9 ). A study of a population in northwest Ethiopia suggested that antigen B was associated with a greater increased risk of T2DM, whereas a O blood group was associated with a lower risk ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Is the Development of Gestational Diabetes Associated With the ABO Blood Group/Rhesus Phenotype?

Lemaître

Passet²,

Ghesquière

et al. 2022

Front. Endocrinol.

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AimsThere are few published data on the putative association between the ABO blood group/rhesus (Rh) factor and the risk of developing gestational diabetes mellitus (GDM). Our aim was to explore the link between each one factor and GDM development.MethodsAll women having given birth at Lille University Medical Center (Lille, France) between August 1st, 2017, and February 28th, 2018, were tested for GDM, using the method recommended in the French national guidelines. The risk of GDM was assessed for each ABO blood group, each Rh phenotype and combinations thereof, using logistic regression models.Results1194 women had at least one GDM risk factor. The percentage of GDM varied with the ABO group (p=0.013). Relative to group O women, group AB women were more likely to develop GDM (OR = 2.50, 95% CI [1.43 to 4.36], p=0.001). Compared with the Rh-positive O group, only the Rh-positive AB group had an elevated risk of developing GDM (OR = 3.02, 95% CI [1.69 to 5.39], p < 0.001).ConclusionsOur results showed that Rh-positive group AB women have a greater risk of GDM. With a view to preventing GDM, at-risk individuals could be identified by considering the ABO blood group phenotype either as a single risk factor or in combination with other risk factors.

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“…Besides their clinical significance in the blood transfusion and compatibility, ABO and Rh blood group antigens were found to be associated with many non-infectious and infectious diseases. 2 , 3 Several studies revealed these blood group antigens were associated with diabetes mellitus, hypertension, gastric cancer, duodenal ulcer, breast cancer, malaria, and helicobacter pylori infection. 2 , 4 , 5 Some other studies also reported that ABO and Rh blood group antigens were associated with transfusion-transmitted infections (TTIs), which include Hepatitis B virus (HBV), human immunodeficiency virus (HIV), Hepatitis C virus (HCV), and syphilis.…”

Section: Introductionmentioning

confidence: 99%

Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

Legese¹,

Shiferaw²,

Tamir³

et al. 2022

JBM

Self Cite

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Background Besides their clinical significance in blood transfusion medicine, ABO and Rh blood group antigens were found to be associated with many non-infectious and infectious diseases. This investigation aimed to assess the association of ABO and Rh blood group antigens with transfusion transmissible infections (TTIs). Methods and Materials A cross-sectional retrospective investigation was conducted on 27,027 blood donors at Bahir Dar blood bank, from March 24/2019 to October 21/2021. The blood sample was collected from each blood donor and tested for TTI markers (HBV, HCV, HIV, and syphilis), with ELISA, and ABO and Rh blood grouping was performed. Descriptive analysis was done for sociodemographic data, and a chi-square test was used to show the association between the ABO and Rh blood groups with TTI markers, and a P-value <0.05 was considered statistically significant. Results From 27,027 study participants, 18,911 (70%) were males, with a mean age of 25.2 years, and 49.4% of the blood donors were students. The overall TTI prevalence was 5.43%, of which 2.8% was HBV, 1.5% was syphilis, 0.8% was HIV, and 0.3% was HCV. Blood group O (41.4%) was the most common blood group followed by, A (29.6%), B (23.6%), and AB (5.4%). Ninety-one point seven percent of the blood donors were Rh (D) positive. All TTI markers (HBV: p = 0.62, HIV: p = 0.77, HCV: p = 0.52, and syphilis: p = 0. 0.94) showed no significant association with ABO blood group. Rh blood type also showed no association with all TTI markers. Conclusion The prevalence of TTI markers was not significantly associated with ABO and Rh blood groups.

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Association of ABO and Rh Blood Group Phenotypes with Type 2 Diabetes Mellitus at Felege Hiwot Comprehensive Referral Hospital Bahir Dar, Northwest Ethiopia

Cited by 12 publications

References 32 publications

Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis

Is the Development of Gestational Diabetes Associated With the ABO Blood Group/Rhesus Phenotype?

Association of ABO and Rhesus Blood Types with Transfusion-Transmitted Infections (TTIs) Among Apparently Healthy Blood Donors at Bahir Dar Blood Bank, Bahir Dar, North West, Ethiopia: A Retrospective Cross-Sectional Study

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