Role of vitamin D in female Reproduction

Shahrokhi, Seyedeh Zahra; Ghaffari, Firouzeh; Kazerouni, Faranak

doi:10.1016/j.cca.2015.12.040

Cited by 89 publications

(82 citation statements)

References 63 publications

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“…Some mechanistic insights have demonstrated that 1α,25(OH)2D alters intracellular calcium mobilisation, which significantly affects sperm motility. VitD also has the potential to modulate inflammation and hormones levels, which are both key aspects for female reproductive function (Shahrokhi et al 2016). It appears that acute exposure can alter oestrogen and progesterone production from primary granulosa cells, and weak evidence indicates an impact on theca cell androgen biosynthesis.…”

Section: Discussionmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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Vitamin D (VitD) is an important secosteroid and has attracted attention in several areas of research due to common VitD deficiency in the population, and its potential to regulate molecular pathways related to chronic and inflammatory diseases. VitD metabolites and the VitD receptor (VDR) influence many tissues including those of the reproductive system. VDR expression has been demonstrated in various cell types of the male reproductive tract, including spermatozoa and germ cells, and in female reproductive tissues including the ovaries, placenta and endometrium. However, the molecular role of VitD signalling and metabolism in reproductive function have not been fully established. Consequently, the aim of this work is to review current metabolic and molecular aspects of the VitD-VDR axis in reproductive medicine and to propose the direction of future research. Specifically, the influence of VitD on sperm motility, calcium handling, capacitation, acrosin reaction and lipid metabolism is examined. In addition, we will also discuss the effect of VitD on sex hormone secretion and receptor expression in primary granulosa cells, along with the impact on cytokine production in trophoblast cells. The review concludes with a discussion of the recent developments in VitD-VDR signalling specifically related to altered cellular bioenergetics, which is an emerging concept in the field of reproductive medicine.Reproduction (2017) 153 R29-R42

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Section: Discussionmentioning

confidence: 99%

Molecular actions of vitamin D in reproductive cell biology

et al. 2017

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“…3 Vitamin D eksikliğinin ağrılı adet görme (primer dismenore, PD), polikistik over sendromu (PCOS), endometriozis, leiomiyom (miyoma uteri, fibroid, UM), erken yumurtalık yetmezliği (prematür over yetmezliği, POF), subfertilite ve over kanseri gibi kadın üreme sistemiyle ilişkili çok sayıda rahatsız-lığın patogenezinde ve etiyolojisinde rol oynayabileceğine dair çeşitli çalışmalar mevcuttur. 4,5 Dolayısıyla bu derlemede, literatürdeki mevcut insan ve hayvan çalışmaları ile in vitro çalışma-ların sonuçları olabildiğince birarada değerlen-dirilerek vitamin D eksikliği ya da yetersizliğinin jinekolojik/obstetrik/onkolojik rahatsızlıklar üzerin-deki olumsuz etkileri, konuya ilişkin ileri sürülen altta yatan olası mekanizmalar ve vitamin D desteği uygulamasının bu rahatsızlıklar üzerindeki olası faydaları ile birlikte kapsamlı şekilde sunulmuştur.…”

Section: Kadın Hastalıklarında Vitamin D Eksikliğininunclassified

“…7,11 Vitamin D, IR ile ilişkili insülin salımının dü-zenlenmesi, insülin reseptör ekspresyonunun uyarılması, insülin duyarlılığının değişimi ve inflamatuar sitokinlerin baskılanması gibi çeşitli doğru-dan ve dolaylı etkileriyle glukoz metabolizmasında görev almaktadır. 4,24 İnsülinsalımı üzerindeki doğru-dan etkisini pankreatik β-hücrelerinde eksprese olan VDR'nin aktivasyonu aracılığıyla göstermektedir. Bu hücrelerde CYP27B1 ekspresyonunun da olmasıyla [1,25( 35 Fizyolojik koşullarda AGEs oluşumu yavaş gerçekleşen bir süreç olsa da PCOS patofizyolojisine önemli katkısı olan IR'nin vücutta yumurtalıkların da dahil olduğu çoğu organda birikme eğilimi gösteren bu ürünlerin oluşum hızını artırabileceği düşünülmektedir.…”

Section: Vi̇tami̇n D Ve Poli̇ki̇sti̇k Over Sendromuunclassified

Assessment of the Possible Role of Vitamin D Defificiency with the Relevant Mechanisms in Gynecological Disorders

Çağlayan¹,

Katlan²

2018

Turkiye Klinikleri J Med Sci

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“…In this context, vitamin D presents an association with fertility, since its acting mechanism impacts on both reproductive cells and immune system cells [5].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, other studies have shown that vitamin d is related to glucose metabolism, through insulin regulation, because of changes in insulin receptor expression and cytokine suppression. Such process may be related to insulin resistance during vitamin d deficiency, consequently resulting in obesity [3,4,5,6,7,8].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D and polycystic ovary syndrome: an integrating review

Lopes¹,

Meireles

Ferreira³

et al. 2017

int arch med

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Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrinopathyin women of reproductive age. It causes a metabolic syndrome characterized by insulin resistance, hyperinsulinemia, and dyslipidemia. Vitamin d deficiency and its association with PCOS still represents a controversial subject in the literature.Objective: In this context, this study aimed to understand the association between polycystic ovary syndrome and vitamin d deficiency, and how it occurs. Method:It was an integrative review conducted in the PubMed, Scopus, LILACS, and CINAHL databases from August 2016 to January 2017, with a sample of 7 articles analyzed in their entirety. Results:The evidences according to the studies conducted and the conclusions they identified. Conclusions:It was concluded that we cannot yet assume that vitamin d deficiency contributes to the pathogenesis of PCOS, nor that the syndrome causes vitamin d deficiency, since the studies are controversial and there is a need for research with higher levels of evidence to clarify these doubts.

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Role of vitamin D in female Reproduction

Cited by 89 publications

References 63 publications

Molecular actions of vitamin D in reproductive cell biology

Molecular actions of vitamin D in reproductive cell biology

Assessment of the Possible Role of Vitamin D Defificiency with the Relevant Mechanisms in Gynecological Disorders

Vitamin D and polycystic ovary syndrome: an integrating review

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