Role of vitamin D and its receptor in regulation of mechanisms of immune inflammation in patients with ischemic heart disease

Abstract

Coronary heart disease still underlies high morbidity and mortality in people of working age. Thus, today one of the most important tasks facing clinical cardiology is the search for new molecular genetic predictors of coronary artery disease associated with the unfavorable course of this disease and the development of complications. In the present review, we analyzed the available data on the mechanisms of vitamin D interrelation with the development of immune inflammation in patients with coronary heart disease. The role of vitamin D and its receptor in cardiovascular diseases and in the development of coronary heart disease, in particular, is considered.Recent studies showed that vitamin D deficiency is a new risk factor for the development of atherosclerosis and immune inflammation. Immune damage of the vascular wall increases the risk of acute coronary syndrome, especially in patients with a predisposition to atherothrombosis. Vitamin D has a multilevel effect on immune inflammation mechanisms by restoring the balance in the system of pro- and anti-inflammatory cytokines. The protective effects of vitamin D on immune inflammation in the vascular wall are realized through vitamin D receptors. The present work re-viewed the studies describing possible mechanisms of immune inflammation regulation by vitamin D and its receptor and activation of immune inflammation in patients with vitamin D deficiency. Further studies of mechanisms of influence of vitamin D receptor on the suppression of immune inflammation are needed.

Nikolau Syndrome: Necrotic Activity of Drugs and Ways to Prevent Post-Injection Abscesses (In memory of Professor László A Gömze)

“…However, it later became clear that local post-injection complications may be aseptic in nature [6][7][8][9][10][11]. In recent years, in Russia the fi ndings show that when applied topically, all drugs can have a mechanism of action not previously described due to physico-chemical properties and/or factors of local interaction [12][13][14][15][16][17]. It is reported that the modern standard for drug quality control and standards for preclinical and clinical drug testing does not include accounting for their osmotic activity, and also allows for diff erent degrees of acidifying and alkalizing activity in medicines considered to be of high quality [18,19].…”