Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses

Janardhan, Avilala; Becnel, David; Abdelghani, Ramsy; Nanbo, Asuka; Kahn, Jacob; Li, Li; Lin, Zhen

doi:10.3389/fmicb.2021.657036

Cited by 9 publications

(14 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly, herpesviruses cannot express antigenic viral proteins during the latency in order to escape the host immune surveillance. Due to immunogenicity lack, circRNAs is likely an ideal strategy for the viruses to regulate themselves and the host environment (157). Therefore, we hypothesize various innate and adaptive immune-associated pathways enhance the chronic viral infection and viral replication, and finally tumor initiation.…”

Section: Circrnas In Non-hbv and Potential Hbv-hccmentioning

confidence: 99%

“…Undoubtedly, virally-encoded circRNAs (vcircRNAs) have different mechanisms and effects in the regulation of signaling pathways involved in viral infection and oncogenesis between HBV-HCC and non-HBV HCC (157). Nevertheless, the vcircRNA research is in signaling pathways regulation where many puzzles remain to be solved.…”

Section: Circrnas In Non-hbv and Potential Hbv-hccmentioning

confidence: 99%

See 1 more Smart Citation

Current Molecular Biology and Therapeutic Strategy Status and Prospects for circRNAs in HBV-Associated Hepatocellular Carcinoma

et al. 2021

View full text Add to dashboard Cite

Circular RNAs (circRNAs) are newly classified noncoding RNA (ncRNA) members with a covalently closed continuous loop structure that are involved in immune responses against hepatitis B virus (HBV) infections and play important biological roles in the occurrence and pathogenesis of HCC progression. The roles of circRNAs in HBV-associated HCC (HBV-HCC) have gained increasing attention. Substantial evidence has revealed that both tissue and circulating circRNAs may serve as potential biomarkers for diagnostic, prognostic and therapeutic purposes. So far, at least four circRNA/miRNA regulatory axes such as circRNA_101764/miR-181, circRNA_100338/miR-141-3p, circ-ARL3/miR-1305, circ-ATP5H/miR-138-5p, and several circulating circRNAs were reported to be associated with HBV-HCC development. Notably, TGF/SMAD, JAK/STAT, Notch and Wnt/β-catenin signaling pathways may play pivotal roles in this HBV-driven HCC via several circRNAs. Moreover, in non-HBV HCC patients or HCC patients partially infected by HBV, numerous circRNAs have been identified to be important regulators impacting the malignant biological behavior of HCC. Furthermore, the role of circRNAs in HCC drug resistance has become a focus of research with the aim of reversing chemoresistance and immune resistance. Herein, we review the molecular biology of circRNAs in HBV-HCC and their potential in therapeutic strategies.

show abstract

Section: Circrnas In Non-hbv and Potential Hbv-hccmentioning

confidence: 99%

Section: Circrnas In Non-hbv and Potential Hbv-hccmentioning

confidence: 99%

Current Molecular Biology and Therapeutic Strategy Status and Prospects for circRNAs in HBV-Associated Hepatocellular Carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…EBV encodes more than 30 different v-circRNAs from dissimilar regions of its genome, which are stably expressed in all EBV-associated tumors [ 352 , 353 , 366 , 367 ]. EBV-encoded circRNAs play a role in viral replication and facilitate EBV pathogenesis and tumor development.…”

Section: Oncoviruses and Circrnasmentioning

confidence: 99%

“…EBV-encoded circRNAs play a role in viral replication and facilitate EBV pathogenesis and tumor development. EBV circRNAs were shown to sponge host cell microRNAs such as miR-31, miR-203, and miR-451, promote proliferation, EMT and cell survival [ 351 , 353 ]. Other microRNA sequestered by EBV circRNAs allowed translation of their target mRNAs, resulting in increased protein levels of, e.g., E2F3, MAPK, checkpoint kinase 1 (CHEK1), and transforming growth factor beta 1 (TGFβ1).…”

Section: Oncoviruses and Circrnasmentioning

confidence: 99%

See 1 more Smart Citation

Role of Virus-Induced Host Cell Epigenetic Changes in Cancer

Pietropaolo¹,

Prezioso

Moens

2021

IJMS

View full text Add to dashboard Cite

The tumor viruses human T-lymphotropic virus 1 (HTLV-1), hepatitis C virus (HCV), Merkel cell polyomavirus (MCPyV), high-risk human papillomaviruses (HR-HPVs), Epstein-Barr virus (EBV), Kaposi’s sarcoma-associated herpes virus (KSHV) and hepatitis B virus (HBV) account for approximately 15% of all human cancers. Although the oncoproteins of these tumor viruses display no sequence similarity to one another, they use the same mechanisms to convey cancer hallmarks on the infected cell. Perturbed gene expression is one of the underlying mechanisms to induce cancer hallmarks. Epigenetic processes, including DNA methylation, histone modification and chromatin remodeling, microRNA, long noncoding RNA, and circular RNA affect gene expression without introducing changes in the DNA sequence. Increasing evidence demonstrates that oncoviruses cause epigenetic modifications, which play a pivotal role in carcinogenesis. In this review, recent advances in the role of host cell epigenetic changes in virus-induced cancers are summarized.

show abstract

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Kamali,

Salehi,

Mostafavi

et al. 2024

Reviews in Medical Virology

View full text Add to dashboard Cite

A significant portion of human cancers are caused by oncoviruses (12%–25%). Oncoviruses employ various strategies to promote their replication and induce tumourigenesis in host cells, one of which involves modifying the gene expression patterns of the host cells, leading to the rewiring of genes and resulting in significant changes in cellular processes and signalling pathways. In recent studies, a specific mode of gene regulation known as circular RNA (circRNA)‐mediated competing endogenous RNA (ceRNA) networks has emerged as a key player in this context. CircRNAs, a class of non‐coding RNA molecules, can interact with other RNA molecules, such as mRNAs and microRNAs (miRNAs), through a process known as ceRNA crosstalk. This interaction occurs when circRNAs, acting as sponges, sequester miRNAs, thereby preventing them from binding to their target mRNAs and modulating their expression. By rewiring the host cell genome, oncoviruses have the ability to manipulate the expression and activity of circRNAs, thereby influencing the ceRNA networks that can profoundly impact cellular processes such as cell proliferation, differentiation, apoptosis, and immune responses. This review focuses on a comprehensive evaluation of the latest findings on the involvement of virus‐induced reprogramming of host circRNA‐mediated ceRNA networks in the development and pathophysiology of human viral cancers, including cervical cancer, gastric cancer, nasopharyngeal carcinoma, Kaposi's sarcoma, hepatocellular carcinoma, and diffuse large B cell lymphoma. Understanding these mechanisms can improve our knowledge of how oncoviruses contribute to human tumourigenesis and identify potential targets for developing optimised therapies and diagnostic tools for viral cancers.

show abstract

Role of Virally Encoded Circular RNAs in the Pathogenicity of Human Oncogenic Viruses

Cited by 9 publications

References 185 publications

Current Molecular Biology and Therapeutic Strategy Status and Prospects for circRNAs in HBV-Associated Hepatocellular Carcinoma

Current Molecular Biology and Therapeutic Strategy Status and Prospects for circRNAs in HBV-Associated Hepatocellular Carcinoma

Role of Virus-Induced Host Cell Epigenetic Changes in Cancer

Hijacking and rewiring of host CircRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) regulatory networks by oncoviruses during development of viral cancers

Contact Info

Product

Resources

About