Multiple sclerosis (MS) involves focal neural demyelmation with relative sparing of axons and resultant impaired nerve conduction. Demyelination commonly affects the posterolateral columns of the spinal cord, with the majority of patients having cervical cord involvement. Forty percent of patients have lumbar cord involvement and 18 percent have sacral cord involvement. The cerebral cortex and midbram may also be affected. Lesions in any of these areas can affect voiding function.Between 50 percent and 90 percent of all MS patients will experience bladder dysfunction during the course of the disease (1-3), and voiding dysfunction is the presentmg symptom m 10 percent of patients (3 ). Therefore, it is imperative that one consider MS in the differential diagnosis of patients with significant voiding complaints. Neurorehabilitation and Neural Repair 1999;13:117-123 © 1999 Demos Medical Publishing sent with a variety of clinical pictures, including mcomplete emptymg, a total inability to void, recurrent urinary tract infections, urmary urgency, urge incontmence, and overflow mcontmence. Detrusor acontractility typically results in a low pressure urinary retention. However, over time, the detrusor compliance may deteriorate. Intravesical pressures may then be elevated even at low volumes.Low bladder compliance can therefore result m inhibited upper tract emptying, hydronephrosis, renal insufficiency, mcontmence, and urinary tract infections (6).